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Interdisciplinary Medicine
Scopus
ISSN 2832-6245 · Wiley-VCH · 225 artikel di indeks
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Artikel Jurnal
Mimicking DOUGONG brackets orchestrate regulating inflammation and mechanical stimuli for osteochondral regeneration using 3D printing
Abstract The microstructure of scaffolds is essential for enhancing cell‐extracellular matrix interactions, which are critical for osteochondral regeneration. This study investigates the innovative use of 3D printing to mimic DOUGONG brackets to achieve this goal. Composite scaffolds of…
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Artikel Jurnal
Advances and challenges in point‐of‐care testing for pathogenic bacteria in battlefield injuries
Abstract Infections are a leading contributor to delayed mortality in patients with combat‐related trauma. Thus, the real‐time, accurate, and rapid detection of invasive pathogens is essential for optimizing wound management and accelerating recovery. Recent innovations in point‐of‐care testing…
Juga tersedia di: DOAJ
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Artikel Jurnal
Comparison of Illumina NovaSeq 6000 and GeneMind SURFSeq 5000 platforms for single‐cell spatial transcriptomics of mouse brain and lung
Abstract Single‐cell spatial transcriptomics enables comprehensive gene expression profiling with precise cellular localization within tissue architecture. To systematically evaluate the compatibility and performance of alternative sequencing platforms for this application, we directly compared…
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Aggregation‐induced emission luminogens in in vitro diagnostics: Advancing biomarker detection in body fluids
Abstract Rapid, sensitive, and accurate detection of ingredients in body fluids is crucial for monitoring health status and diagnosing diseases. Fluorescent biosensors have emerged as a user‐friendly tool for biomarker detection, because of their high sensitivity, rapid response, and adaptability…
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Artikel Jurnal
Extracellular vesicle‐based vaccines and immunotherapeutics for treatment of cancer
Abstract In recent years, cancer immunotherapy has gained substantial momentum, particularly in the field of vaccines and immunotherapeutics. Among these advancements, extracellular vesicles (EVs) have emerged as a promising cell‐free vaccine system due to their unique capacity to display diverse…
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Artikel Jurnal
Progress in the detection of gut microbiota based on microfluidic technology
Abstract Gut microbiota, a complex microbial community in the human intestine, are vital for digestion, nutrient absorption, and immune regulation, maintaining gut micro‐ecological balance. Accurate detection of its composition, structure, and function is crucial for understanding the relationship…
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Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions
Abstract Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis and arises from the convergence of genetic susceptibility, environmental exposures, immune dysregulation, and gut microbiome perturbations. Metabolic reprogramming has emerged as a central feature of IBD…
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Artikel Jurnal
Nanoparticle‐integrated electrostimulation‐responsive biomaterials: Innovations in drug delivery and tissue repair in clinical regenerative medicine
Abstract Tissue engineering holds immense promise for repairing damaged tissues and organs, yet current approaches often fall short due to poor host integration, limited drug delivery precision, and scalability challenges. Recent developments in electrostimulation‐responsive biomaterials…
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A clustered regularly interspaced palindromic repeat‐Cas12a‐based assay for rapid dengue virus monitoring in mosquito and clinical samples facilitating global collaborative surveillance and risk assessment to block dengue spreading
Abstract Dengue fever, an acute Aedes‐borne infectious disease caused by the dengue virus (DENV), is a substantial global health challenge, necessitating the development of swift and effective surveillance methodologies. We have developed a Recombinase Aided Amplification (RAA)–Cas12a assay that…
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Artikel Jurnal
Vat photopolymerization‐based bioprinting: Shaping next‐generation tissues with light
Abstract Vat photopolymerization (VP)‐based bioprinting is rapidly emerging as a transformative platform for fabricating complex, cell‐laden tissue constructs with unparalleled spatial resolution and geometric precision. This review presents a comprehensive overview of recent advances in VP‐based…
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Artikel Jurnal
TargetGen‐RNN model discovers novel antibiotic compound targeting drug‐resistant Staphylococcus aureus
Abstract The escalating threat of antibacterial resistance demands innovative approaches for the discovery of novel antibiotics. Identifying hit and lead compounds with unique scaffolds during the early phases of drug development remains a significant challenge. Although various generative models…
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Artikel Jurnal
Nanoengineered neutrophils integrated with magnetic nanoparticles for T2‐weighted magnetic resonance imaging‐guided enhanced magnetic hyperthermia therapy of pancreatic tumor
Abstract In recent years, magnetic hyperthermia therapy (MHT), recognized as a clinically promising anticancer treatment, has focused on enhancing therapeutic outcomes in tumor management, such as optimizing magnetic nanoparticle accumulation within tumor microenvironments and developing…
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Anti‐CD47 antibody‐decorated and cisplatin‐containing mesoporous silica nanoparticles for targeted chemoimmunotherapy of colorectal cancer in a patient‐derived organoids xenograft model
Abstract For colorectal cancer (CRC), treatment outcomes and prognosis remain poor even when using first‐line chemotherapeutics and immunotherapeutics. The main reasons include (i) lack of tumor specificity, severe off‐target cytotoxicity leading to adverse side effects, and occurrence of…
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Artikel Jurnal
Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance
Abstract Bacillus Calmette‐Guérin (BCG) immunotherapy is limited by resistance in ∼50% of patients, linked to tumor microenvironment (TME) angiogenesis. The work explored if BCG‐activated tumor‐associated macrophages (TAMs) drive angiogenesis via hypoxia‐inducible factor‐1α (HIF‐1α) to impair BCG…
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Artikel Jurnal
Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling
Abstract Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with orofacial pain and impaired joint function. However, the mechanisms are not well understood. Sel1l‐mediated endoplasmic reticulum‐associated degradation (ERAD) orchestrates protein homeostasis. Here, we…
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Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia
Abstract Metabolic reprogramming is a hallmark of cancer and serves as a potential therapeutic target, whereas the metabolic feature of acute lymphoblastic leukemia (ALL) was marginally addressed. Based on RNA‐sequencing data in an in‐house and external cohort, we aimed to dissect metabolic feature…
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Artikel Jurnal
Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification
Abstract Gut dysbiosis is tightly linked to type 2 diabetes (T2D) arterial calcification (AC), but the mechanism of gut dysbiosis remains poorly defined. Here, we found that a T2D AC associated‐gut Bacteroides fragilis (BF) was activated by M1 macrophage‐derived extracellular vesicles (EVs). BF…
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FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer
Abstract Docetaxel remains a mainstay in the treatment of prostate cancer; however, docetaxel resistance continues to pose a major challenge and is associated with unfavorable patient outcomes. Efforts to overcome known resistance mechanisms have largely failed to improve survival, often increasing…
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Recent advances and clinical applications of 3D printing for female reproductive organ regeneration and gynecological disease
Abstract The integration of three‐dimensional (3D) printing and bioprinting technologies has significantly reshaped the landscape of gynecological medicine, offering innovative strategies to address clinical challenges related to reproductive organ disorders and gynecological malignancies. This…