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Pediatric Discovery
ISSN 2835-5598 · Wiley · 180 artikel di indeks
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Artikel Jurnal
Median Effective Volume of 0.2% Ropivacaine for Ultrasound‐Guided Axillary Brachial Plexus Block in Children Aged 6–10 Years: A Prospective Dose‐Finding Study Using Up‐and‐Down Sequential Allocation
ABSTRACT The optimal dose for ultrasound‐guided axillary brachial plexus block (ABPB) in children remains poorly defined. This study aimed to find the median effective volume (EV50) of ropivacaine (0.2%) for ABPB in children aged 6–10 years. A prospective, double‐blind, dose‐finding trial using the…
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Artikel Jurnal
HucMSC‐Derived Exosomes Preserve Mafb‐Dependent Tubular Epithelial Identity and Suppress Dedifferentiation in Obstructive Nephropathy
ABSTRACT Tubular epithelial dedifferentiation and loss of polarity are early pathological events in obstructive nephropathy and critically contribute to progressive renal fibrosis. Human umbilical cord mesenchymal stem cell–derived exosomes (HucMSC‐Exos) have shown therapeutic potential for kidney…
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Artikel Jurnal
Cognitive Abilities and Their Implications for Language and Speech Disorders—Insights From Phoniatric Practice
ABSTRACT Children with language and speech disorders account for approximately 5%–12% of children have language and speech disorders globally. Understanding the cognitive abilities of these children is crucial for identifying how cognitive skills influence speech fluency, language production, and…
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Artikel Jurnal
Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments
ABSTRACT Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by abdominal pain and changes in bowel habits. Cinnamaldehyde (CA) possesses anti‐inflammatory, antibacterial, and digestive‐regulatory properties. However, its therapeutic potential for IBS…
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Artikel Jurnal
Impact of the 2019 Novel Coronavirus Pandemic on Canadian Pediatricians
ABSTRACT The COVID‐19 pandemic has significantly impacted the well‐being and practices of healthcare workers. The primary goal of this study was to assess the rate of burnout among Canadian pediatricians during the pandemic using all three components of the Maslach Burnout Inventory—Human Services…
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Artikel Jurnal
Human Umbilical Cord Mesenchymal Stem Cell‐Derived Microvesicles Alleviate Bronchopulmonary Dysplasia in Preterm Rats by Inhibiting Neutrophil Extracellular Trap Formation
ABSTRACT Among preterm infants, bronchopulmonary dysplasia (BPD) is the most prevalent chronic pulmonary disorder. Its pathogenesis involves a complex interplay between prenatal inflammatory exposure and abnormal immune activation. Neutrophil extracellular traps (NETs) are mediators of tissue…
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Artikel Jurnal
Latent Class Analysis of Pediatric Bronchial Foreign Body Complications and Their Associated Factors
ABSTRACT This study aimed to provide a theoretical basis for improving early diagnosis and complication prevention by exploring the latent classes of pediatric bronchial foreign body complications, analyzing their associated factors, and assessing the impact of different latent classes on…
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Artikel Jurnal
Umbrella Review for Pediatric Sepsis and Robust Prediction Potential Worldwide
ABSTRACT Pediatric sepsis remains a significant global health burden with considerable mortality and morbidity, particularly in resource‐limited settings. This umbrella review synthesizes current evidence from systematic reviews and meta‐analyses on the definitions, epidemiology, diagnostic…
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Screen Exposure and Academic Achievement: A Systematic Review
ABSTRACT This systematic review examined recent evidence on how screen exposure influences the development of academic skills and educational achievement. Digital technologies have become central to children's daily lives, reshaping both learning opportunities and leisure activities. Although…
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Artikel Jurnal
Enhanced Family‐Centered Care and Family Integrated Care for Preterm Infants in Neonatal Intensive Care Units: Comparative Outcomes and Implementation Features—A Scoping Review
ABSTRACT This scoping review maps and compares evidence on enhanced or modified Family‐Centered Care (FCC) models—including Family Integrated Care (FICare) and related variants—against standard FCC/usual neonatal intensive care unit (NICU) care for preterm infants. We aimed to summarize the…
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Artikel Jurnal
Longitudinal Single‐Cell Transcriptomic Profiling Reveals Dynamic Immune Cell Alterations During Burosumab Therapy in X‐Linked Hypophosphatemia
ABSTRACT X‐linked hypophosphatemia (XLH) is a rare hereditary disorder characterized by PHEX gene mutations, elevated FGF23 levels, and impaired bone mineralization. Burosumab, a monoclonal antibody targeting FGF23, has demonstrated clinical efficacy; however, the immunological dynamics during…
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Artikel Jurnal
Jervell and Lange‐Nielsen Syndrome Related Clinical Genetics and Experimental Models
ABSTRACT Jervell and Lange‐Nielsen syndrome (JLNS) is defined by electrocardiographic QT prolongation and sensorineural hearing loss, caused by homozygous or compound heterozygous variants in KCNQ1 and/or KCNE1. KCNQ1 encodes the alpha subunit Kv7.1 of the ion channels accountable for slow delayed…
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Artikel Jurnal
The Airway Epithelial Barrier in Childhood Asthma: A Central Player in Glucocorticoid Therapy, Resistance, and Severe Asthma
ABSTRACT Childhood asthma remains a global public health challenge with suboptimal control, despite the availability of inhaled corticosteroids (ICS) as first‐line therapy. Glucocorticoids suppress inflammation and protect the airway epithelial barrier (AEB) via genomic and nongenomic pathways…
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Artikel Jurnal
Mild Malnutrition in Children Aged 6–24 Months and Related Influencing Factors: Research From an Outpatient Clinic of Pediatric Health Care
ABSTRACT Mild malnutrition in infants and young children is an early stage of nutritional deficiency characterized by a slight reduction in nutritional reserves and mild impairment of physiological functions but no obvious clinical symptoms or severe growth retardation. Parents often overlook this…
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Artikel Jurnal
A Comprehensive Review of the Genetic Etiology and Management of Orofacial Clefts
ABSTRACT Cleft lip (CL) and cleft palate (CP), collectively referred to as orofacial clefts (OFCs), are among the most common birth defects and can have significant effects on speech, nutrition, and physical and psychosocial development. Manifestation, classification, and treatment plans of OFCs…
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Artikel Jurnal
Pediatric Cardiac Function Staging and Management Recommendations
ABSTRACT The global prevalence of heart failure in children continues to increase, accompanied by a growing disease burden. To advance early prevention and intervention by shifting the focus upstream in the disease process, the Cardiovascular Group of the Pediatrics Society of the Chinese Medical…