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Epigenetics Reports
ISSN 2836-1512 · Taylor & Francis Group · 23 artikel di indeks
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Artikel Jurnal
Chromatin meets condensates: emerging interplays linking nuclear paraspeckles to gene activation
Nuclear paraspeckles are membrane-less protein–protein and protein-RNA condensates that assemble co-transcriptionally upon the expression of long non-coding RNA NEAT1. While efforts in the past two decades extensively characterized the components and structures of nuclear paraspeckles, their…
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Immuno-Southern blot assay: combined detection of DNA modifications with methylation-responsive restriction Enzymes and antibody screening
DNA base modifications influence genome function in both prokaryotes and eukaryotes, yet their detection often relies on specialised and resource-intensive technologies. Here we present immuno-Southern (iSouthern), a simple method that combines two independent detection strategies within a single…
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Loss of MUC1 methylation haplotype complexity defines a distinct epigenetic architecture in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) harbours recurrent epigenetic alterations, but locus-specific DNA methylation haplotype architecture remains poorly defined. Conventional methylation analyses report average methylation levels and cannot resolve CpG arrangements on individual DNA molecules…
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Prediction of biological age and blood biomarkers from DNA methylation profiles measured by the methylation screening array: development and validation of models on Japanese data
Epigenetic clocks based on DNA methylation (DNAm) are widely used indicators of biological aging; however, most models were developed using EPIC arrays and non-Japanese populations. The Methylation Screening Array (MSA), a cost-efficient platform with reduced CpG content, has not been evaluated for…
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ADAR1 as an epitranscriptomic arbiter and genome guardian: rewiring gene expression through the A-to-I editome
ADAR1 catalyzes the conversion of adenosine to inosine in double-stranded RNA (dsRNA) substrates, providing a biological means to regulate cellular responses via gene expression rewiring. This review will highlight the primary functions of ADAR1 and describe how the combination of these…
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Epigenomic profiling of H3K27ac in a primary patient-derived multiple myeloma cell line using two different low-input methods with concordant results
Investigating histone post-translational modifications (PTMs) in cancer, including multiple myeloma (MM), is crucial for elucidating epigenetic mechanisms that drive malignant transformation, disease progression, and drug resistance. Indeed, in MM, aberrant epigenetic mark patterns are increasingly…
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The effects of methylphenidate and atomoxetine on epigenetic DNA modifiers in an in vitro model of human peripheral blood mononuclear cells
Attention-deficit hyperactivity disorder (ADHD) is a childhood neurodevelopmental disorder affecting approximately 5%–8% of children. Adults with persistent childhood-onset ADHD have twice the risk of developing substance use disorder (SUD) compared to those without ADHD. While various drugs can…
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Training healthcare professionals in the epigenetics of depression: a training of trainers and case-based learning experience
Depression is a complex condition shaped by dynamic interactions between genetic vulnerability, environmental exposures, and epigenetic mechanisms. This experience report describes a pilot educational intervention designed to train healthcare professionals in the epigenetics of Depression using a…
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Artificial intelligence meets epigenetics: a new frontier in precision oncology
Epigenetics involves heritable and stable changes in gene expression that occur without altering the DNA sequence, primarily through chemical modifications to DNA and alterations in chromatin structure. Dysregulation of these epigenetic processes is widely recognized as a hallmark of cancer…
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Maternal diet quality in pregnancy and human milk extracellular vesicle and particle microRNA
Extracellular vesicle and particle microRNAs (EVP miRNA) in milk have the capacity to facilitate maternal-infant communication in the postpartum period and are hypothesized to play important roles in child development. Maternal diet quality has been linked to milk macronutrient composition…
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Epigenetic basis for environmentally induced liver disease
The liver, which is central to detoxification and metabolism, interacts with growing threats from environmental exposures that alter epigenetic mechanisms and contributes to the development of liver disease. Dietary contaminants, industrial chemicals, and lifestyle factors induce aberrant DNA…
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Implication of the Mediator kinase module in CIZ1 recruitment and gene silencing by Xist during the initiation of X inactivation
In mammals, dosage compensation between the sexes is mediated by X chromosome inactivation. The long non-coding Xist RNA initiates this process. The molecular mechanism of X-linked gene silencing is beginning to be understood. We have previously reported that the cyclin-dependent kinase CDK8 is…
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Extracellular vesicle-derived DNA methylation cargos: linking disease mechanisms, biomarkers, and therapeutic potential – a mini review
Extracellular vesicles (EVs) are lipid-bilayered nanoparticles that are released by all cells and carry cargos reflective of their cell of origin, including nucleic acids, proteins, and lipids. This narrative review provides a brief overview of EVs and their characterization and then examines the…
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Normal gastric tissue Helicobacter pylori infection is associated with tissue cell composition, and cell type–specific epigenetic age acceleration, mitotic tick rate, and repetitive element methylation alterations
Helicobacter pylori (H. pylori)infection is a well-established risk factor for gastric adenocarcinoma, one of the leading causes of cancer-related death worldwide. While H. pylori infection induces significant DNA methylation changes, the cell type–specific epigenetic mechanisms contributing to…
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Novel HumanMethylation450 array analysis identified potential predictors of future diabetes in women with polycystic ovarian syndrome
Women with polycystic ovarian syndrome (PCOS) are at significantly increased risk of type 2 diabetes mellitus. However, while studies have identified patient-related factors associated with diabetes risk in PCOS and others have explored epigenetic changes in women with PCOS and healthy controls, we…
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DNA methylation profiling in archived FFPE renal biopsies: a pilot study of epigenetic markers of albuminuria in diabetic kidney disease
Diabetes Mellitus is the leading risk factor for kidney failure, yet current biomarkers such as urinary albumin-to-creatinine ratio (UACR) lack tissue specificity and sensitivity for early detection of Diabetic Kidney Disease (DKD). DNA methylation provides insight into kidney-specific epigenetic…
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KMT2D-deficiency destabilizes lineage progression in immature neural progenitors
Neurodevelopment is driven by the tightly regulated integration of chromatin shaping, transcription, and proliferation. Although KMT2D is known to catalyze activating H3K4 methylation marks at promoters and enhancers, its role in regulating early fate decisions of neural progenitors remains poorly…
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DNA methylation clocks and cognitive status among older adults in the US, NHANES 1999–2002
Biological aging, measured using DNA methylation, is a potential biomarker for cognitive health outcomes. We evaluated associations between DNA methylation clocks and cognition in a nationally representative sample of adults aged 60+ in the National Health and Nutrition Examination Survey (NHANES)…
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Vafidemstat: a lysine-specific demethylase 1A inhibitor that shows promise for treating neuropsychiatric disorders
The enzyme KDM1A encoded by KDM1A and also known as lysine-specific demethylase 1 (LSD1) plays important roles in the development and function of the brain. Vafidemstat is a KDM1A inhibitor that has shown beneficial effects in preclinical and clinical trials for the treatment of neuropsychiatric…