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npj Women's Health
ISSN 2948-1716 · Nature Portfolio · 124 artikel di indeks
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Artikel Jurnal
A chronobiology-based protocol for multi-omic mapping of menstrual cycle and diurnal rhythms in ME/CFS and long COVID
Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystem illnesses with overlapping symptoms and poorly understood mechanisms. Female sex is a major risk factor, and preliminary evidence links sex hormones and other fluctuating endocrine…
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Rethinking endometriosis recurrence: from clinical challenge to biological opportunity
Abstract Endometriosis postoperative recurrence remains a major clinical challenge and a poorly understood biological process, directly impacting long-term care. This narrative review integrates current knowledge on recurrence definitions, patterns, risk factors, and prevention strategies…
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Atrial fibrillation and thromboembolic stroke risk in women
Abstract Atrial fibrillation (AF) is a leading cause of cardiovascular disease. Women have a higher risk of AF-related stroke and poorer outcomes than men. Despite this, women are underrepresented in anticoagulation trials and receive fewer advanced interventions. Many studies lack sex-specific…
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Feasibility and acceptability of menstrual underwear among women in displacement-prone Kalehe, Democratic Republic of Congo
Abstract Menstrual hygiene management (MHM) remains a critical yet often neglected issue in humanitarian settings. Reusable menstrual underwear (MU) offers a sustainable option where disposable products are limited, but evidence from low-income settings is scarce. This mixed-methods study assessed…
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State of the science and research opportunities on dietary patterns in endometriosis and uterine fibroids
Abstract Endometriosis and fibroids are prevalent uterine conditions. Mechanisms for both conditions—immune dysfunction, inflammation, and sex hormone dysfunction—are plausibly influenced by diet. Here, we review the epidemiology and pathophysiology, and synthesize evidence on dietary patterns…
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Artikel Jurnal
Mobile device data for the study of miscarriage and its causes
Abstract Miscarriage is a common pregnancy complication that is difficult to study. Using information on 580,000 US pregnancies from a menstrual- and pregnancy-tracking app, we demonstrate that mobile device data can detect miscarriage and replicate patterns of miscarriage risk found in…
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Finger-prick transcriptomic profiling in northern Nigeria reveals a muted maternal systemic response in stillbirth
Abstract Inflammation is implicated in placental dysfunction leading to stillbirth, yet evidence of a systemic immune response during parturition remains unclear. Here, we present the first transcriptomic analysis of maternal systemic responses associated with stillbirth, using a minimally invasive…
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The acceptability and feasibility of a contextualised group-based maternal mental health intervention in Kenya
Abstract Maternal mental health (MMH) is a critical yet neglected aspect of care in low- and middle-income countries (LMICs) due to stigma, limited awareness, and insufficient mental health professionals. Task-sharing with trained lay facilitators offers a promising solution. This study evaluated…
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Implementation of brief stop smoking advice at cervical cancer screening in general practice: a process evaluation
Abstract Cervical cancer screening has potential as a teachable moment for smoking cessation. Smoking is a recognized risk factor for persistent high-risk human papillomavirus infection of the cervix and the development of cervical neoplasia. The cluster randomized SUCCESS trial tested brief stop…
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Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality
Abstract Paraben esters are endocrine disruptors linked to breast cancer, yet their role in other estrogen-mediated cancers remains limited. Preclinical evidence suggests that parabens accumulate in tissues and may promote carcinogenesis, while clinical data indicate widespread exposure. Our…
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Development and validation of a person-centered antenatal care scale for low- and middle-income countries
Abstract We aimed to develop and validate a tool to comprehensively measure person-centered antenatal care (PCANC) in low- and middle-income countries (LMICs). We followed standard procedures for scale development, including literature review, expert reviews, cognitive interviews, and pretesting to…
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Decoding menstrual health across the lifespan: a scoping review of digital health tools in research
Abstract Digital health tools provide longitudinal physiological and behavioural data that can address knowledge gaps in women’s health. This is particularly relevant for understanding hormone-driven physiological changes and symptoms, which impact health and performance across the lifespan. We…
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Citizen science reveals comorbidities in endometriosis with no shift in vaginal microbiome composition
Abstract Endometriosis is a chronic inflammatory condition affecting 2–10% of reproductive-aged women, most commonly presenting with pelvic pain and subfertility. While its impact on reproductive health is increasingly recognized, the vaginal microbiome’s role in the pathogenesis of endometriosis…
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The wrongs of negative pronatalism
Abstract In this article, I claim that pronatalist policies that not only reward those who have (more) children, but penalize those who do not, constitute what I call negative pronatalism. I argue that negative pronatalism exacerbates autonomy infringements, inequalities, and other harms to those –…
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A foundation model for capturing complexity of menstrual health data
Abstract Despite its centrality to women’s health, the menstrual cycle remains understudied in computational health research due to its complexity, variability, and limited data availability. Recent advances in generative artificial intelligence (AI) offer new opportunities for modeling…
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Multi-omics investigation of metabolomic and microbial features in bacterial vaginosis
Abstract Bacterial vaginosis (BV) affects 23–29% of reproductive-age women globally and recurs in over half of cases within 6 months, yet the coordinated metabolic and genomic mechanisms underlying it remain incompletely understood. In this cross-sectional study of 111 Swedish women (29 with BV, 82…
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Still in the dark: effects of sex differences on statin-associated diabetes risk
Statins reduce cardiovascular risk but modestly increase type 2 diabetes (T2D). Evidence is limited by underrepresentation of women and lack of sex-specific analyses. In an umbrella review and meta-analysis of 21 trials with sex-disaggregated data, statins increased T2D risk similarly in women (OR…
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Combination of oxidative phosphorylation and platelet-derived growth factor inhibitors for the treatment of ovarian cancers
Abstract The combination therapy of FDA approved oxidative phosphorylation inhibitors (metformin and atovaquone) and platelet derived growth factor inhibitors (sunitinib and sorafenib) could target ovarian cancer stem-like cells (CSCs) and carcinoma associated mesenchymal stem cell enrichment of…
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Leveraging multimodal machine learning for accurate risk identification of intimate partner violence
Abstract Intimate partner violence (IPV) refers to the abuse from previous or current partners. It is a widespread but underreported public health concern that has a wide range of negative effects on the physical and mental health of those affected. This work presents machine learning models for…