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Journal of Preventive, Diagnostic and Treatment Strategies in Medicine
ISSN 2949-6594 · Wolters Kluwer Medknow Publications · 187 artikel di indeks
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Artikel Jurnal
Comparative Analysis of Microbes Associated with Fruit Juices and Determination of their Contamination Sources
BACKGROUND: Fresh juice plays a significant role in everyday diet but conversely may be contaminated by different types of microorganisms. The present study attempted to determine the microbiological quality of fresh juice samples and their sources of contamination. METHODS: A total of thirty…
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Artificial Intelligence for Early Prediction of Maternal Cardiopulmonary Deterioration in Pregnancy Using Multimodal Digital Biomarkers: A Systematic Review
Digital health technologies and artificial intelligence (AI) have expanded the capacity for continuous physiologic monitoring during pregnancy. While wearable-derived digital biomarkers are increasingly studied, evidence specific to the early detection of maternal cardiopulmonary deterioration…
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Enhancing Health Literacy for People with Cystic Fibrosis: Can Artificial Intelligence – Generated Lay Summaries Improve Readability of Scientific Abstracts?
BACKGROUND : Cystic fibrosis (CF) is a rare disease with complex pathophysiology. This complexity makes it difficult for healthcare professionals to articulate and explain its background, diagnosis, treatments, and therapies to people with CF (PwCF), particularly with the arrival of CFTR modulators…
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Placenta-informed Precision Maternal Vaccinology: Designing Pregnancy Vaccines for Selective Antibody Transfer, Neonatal Protection, and Infant Immune Programming
Maternal immunization has increasingly been recognized as a practical strategy to protect infants during the earliest months of life, a period when the neonatal immune system remains immature and vulnerability to infection is high. Despite this progress, most vaccination programs during pregnancy…
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MicroRNA-augmented First-trimester Precision Prediction for Placenta-mediated Disorders: A Systematic Review and Evidence-to-algorithm Translation Framework Integrating Clinical Variables and the Fetal Medicine Foundation Competing-risks Model
Placenta-mediated disorders remain major causes of maternal and perinatal morbidity because they are typically detected only after clinical trajectories are established. MicroRNAs (miRNAs), released from the placenta early in pregnancy, have emerged as promising first-trimester biomarkers, yet…
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Diabetic Nephropathy and Oxidative Stress
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease worldwide and represents a major complication of diabetes mellitus. Increasing evidence implicates oxidative stress (OS) as a central driver in the initiation and progression of DN through complex molecular and cellular…
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Assessment of Hematological Indices in Patients with Thyroid Disease Compared with Healthy Control
INTRODUCTION: Various hematological parameters are affected by thyroid hormone metabolism; however, the patterns of these effects and how it can be used in diagnosis have not been well established. This research was conducted to assess and compare hematological parameters in patients with thyroid…
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Cytokeratin 19 Gene Expression in Patients undergoing Lung Computed Tomography Scan: With and without Bismuth Shield
BACKGROUND: Lung computed tomography (CT) scan is one of the most widely used imaging methods that exposes patients to ionizing radiation. This radiation can cause molecular changes, including changes in gene expression. The aim of this study was to evaluate and compare cytokeratin 19 (CK19) gene…
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Metabolic Vulnerability and Immune Challenge: Interactions Between Inherited Disorders, Metabolic Syndrome, and Infection Risk
Inherited metabolic disease (IMDs) are rare genetic disorders with an enzyme and/or transport system dysfunction of a metabolic pathway. Infections frequently induce acute metabolic decompensation in patients with IMDs and may also compromise the outcome of disorders not primarily recognized as…
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Assessment of the Antibacterial Properties of Mangifera Indica Extracts against Clinically Relevant Gram-Positive and Gram-Negative Bacteria
BACKGROUND: Antimicrobial resistance is a growing global health threat that has reduced the effectiveness of many conventional antibiotics, highlighting the need for alternative antimicrobial agents. Mangifera indica, widely used in traditional medicine, contains bioactive phytochemicals with…
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Regularization Logistic Regression Models for Hepatitis B Virus Risk Factors in Algeria, 2025
BACKGROUND: Hepatitis B virus (HBV) remains a major global health challenge, particularly in high-prevalence regions, where early diagnosis and targeted prevention strategies are essential to reduce disease burden and transmission. Strengthening predictive approaches is critical for improving…
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Codon-optimized Glucocerebrosidase cDNA Is Not Sufficient for Recombinant Expression in Pichia pastoris
BACKGROUND: Gaucher disease is a lysosomal storage disorder caused by mutations in the GBA1 gene, leading to a deficiency of the enzyme glucocerebrosidase (GCase). Current enzyme replacement therapies are expensive due to production in mammalian systems. This study aimed to evaluate the expression…
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Comparative Assessment of Serum Creatine Kinase-MB to Total Creatine Kinase Ratio in Cerebrovascular Accident and Transient Ischemic Attack Patients
BACKGROUND: Stroke is the third-leading cause of death and one of the major causes of long-term disability globally. Evaluating serum enzymes has been proposed as a straightforward, cost-effective, reliable, and accessible method for assessing the severity, progression, prognosis, and, to some…
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Determination of Antibacterial Activity of Natural Products against Clinical Isolates from Renowned Diagnostic Centers in Dhaka, Bangladesh
BACKGROUND: Antimicrobial resistance among foodborne pathogens poses a growing public health challenge, particularly in low-resource settings, necessitating exploration of plant-derived antibacterial agents. MATERIALS AND METHODS: This retrospective exploratory laboratory-based study was conducted…
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Prevalence and Distribution of Urinary Tract Infections among Human Immunodeficiency Virus Outpatients in a Tertiary Hospital in Jalingo, Taraba State
BACKGROUND: Human immunodeficiency virus (HIV) infection increases susceptibility to opportunistic infections, including urinary tract infections (UTIs). However, data on the burden of UTI among HIV-positive outpatients in Jalingo, Taraba State, Nigeria, are limited. Therefore, this study assessed…
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Artikel Jurnal
Nanoparticle-based Irrigants: Future of Endodontic Disinfection?
Effective disinfection of the root canal system is critical for endodontic success; however, conventional irrigants such as sodium hypochlorite and chlorhexidine are limited by cytotoxicity, restricted penetration into dentinal tubules, and incomplete biofilm elimination. Advances in nanotechnology…
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Iodine, Selenium, and Vitamin D in Pregnancy: A Systematic Review of Their Integrated Effects on Thyroid and Glucose Metabolism, Maternal–Fetal Outcomes, and Risk-Tailored Supplementation Strategies
Pregnancy is characterized by profound endocrine adaptation, in which micronutrient availability plays a central but often compartmentalized role. Iodine, selenium, and Vitamin D are individually recognized as essential for thyroid function, glucose regulation, and immune balance; however…
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Artikel Jurnal
C-X-C Motif Chemokine Ligand 10 as a Potential Biomarker of Heart Transplant Rejection: A Comparative Study in Peripheral Blood
BACKGROUND: Heart transplant rejection remains a major posttransplant complication. Endomyocardial biopsy, the diagnostic gold standard, is invasive and costly. This study aimed to evaluate peripheral blood (C-X-C motif chemokine ligand 10 [CXCL10]; IP-10) as a noninvasive molecular biomarker for…
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Artikel Jurnal
Clinical, Paraclinical, and Microbiological Trajectories of Hospitalized Patients with Cystic Fibrosis across Successive Admissions
BACKGROUND: Cystic fibrosis (CF) is a chronic multisystem disease characterized by recurrent pulmonary exacerbations necessitating hospitalization. Although repeated admissions are commonly linked to disease progression, limited data exist on longitudinal changes across such hospitalizations. This…
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Developing a Green Management Standards Model for an Infectious Disease Hospital: A Qualitative Content Analysis
BACKGROUND: A green hospital recognizes the relationship between human health and the environment, incorporates this knowledge into its management, strategies, and operations, and significantly contributes to improving the quality of life in the community. The presence of infectious diseases…