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Biomedical Technology
Scopus
ISSN 2949-723X · KeAi Communications Co., Ltd. · 118 artikel di indeks
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Artikel Jurnal
Mechanically engineered extracellular vesicles technology: Regulatory mechanisms and therapeutic applications in orthopedic diseases
Background: An increasing number of studies have shown that extracellular vesicles (EVs), as key mediators of intercellular communication, serve as a crucial bridge between the mechanical microenvironment and bone metabolic homeostasis. However, the molecular mechanisms underlying mechanically…
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Artikel Jurnal
Intradermal delivery of N1-methylpseudouridine-modified BCL-2 mRNA as a programmable gene therapy to reverse UVB-induced skin photoaging
Background: Photoaging, driven by ultraviolet-B (UVB)–induced oxidative and inflammatory cascades, accelerates extracellular-matrix degradation and remains difficult to reverse with current small-molecule, topical, or device-based approaches. Network-based bioinformatics analyses implicate BCL-2 at…
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Adipose tissue as a universal organoid factory: bypassing single-cell processing for multilineage regeneration
Human adult adipose tissue, obtained from routine liposuction, can directly generate functional organoids spanning all three germ layers without single-cell isolation or genetic manipulation. In the landmark study discussed here, Huang et al. demonstrate tri-lineage competence from a single…
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Artikel Jurnal
Bacterial extracellular vesicle technology for precision cancer medicine: Biotechnological advances and applications
Background: Bacterial extracellular vesicles (BEVs) are nanoscale secretions containing proteins, lipids, nucleic acids, and metabolites that modulate immune pathways, reshape the tumor microenvironment, and influence multiple stages of tumor progression. These properties position BEVs as promising…
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Artikel Jurnal
The pH-responsive permeation mechanism of zwitterionic polymers promotes transdermal insulin delivery
The transdermal delivery of macromolecular drugs has long been limited by the barrier effect of the stratum corneum and the underlying active epidermis. A recent study published in Nature proposed a non-invasive transdermal delivery strategy based on poly[2-(N-oxide-N,N-dimethylamino)ethyl…
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One-step microfluidic technology for generating multifunctional quantum dot (QD) biomarker barcode particles for multiplex pathogen detection
Background: High throughput, multiplex analysis, and operational convenience are essential for biomedical diagnostics. Quantum dot (QD) barcode particles hold significant promise for biomarker detection due to their powerful encoding capabilities. However, conventional QD encapsulation methods…
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Artikel Jurnal
Dynamic mechanical properties of the rat aged spinal cord tissue: Characterization of elasticity, viscoelasticity, and non-linearity
Ageing plays a pivotal role in spinal cord (SC)-related disorders, but the impact of ageing on the SC, especially with respect to its material properties, remains poorly understood. Prior investigations have primarily focused on static uniaxial testing, leaving dynamic mechanical assessment…
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Artikel Jurnal
Next-generation 3D bioprinted inner ear organoids
Background: Inner ear is crucial for maintaining normal functions of human sensory perception. However, current perceptual reconstruction is mostly limited to symptomatic relief and lacks a radical cure for irreversible damage. The development of new strategies for the fundamental treatment of…
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Redox-responsive carrier-free nanoassemblies enable dual topoisomerase I/II inhibition for metastasis-suppressed breast cancer therapy
Background: Breast cancer remains a critical unmet clinical challenge due to its aggressive metastasis behavior and limited treatment options. Topoisomerase inhibitors are widely available clinically but fail to address the compensatory upregulation of alternative isoforms in metastatic breast…
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Artikel Jurnal
Biocompatible screw-based biomechanical alignment technique for improving surgical effect in adolescent flexible flatfoot
Background: The surgical management of adolescent flexible flatfoot with accessory navicular injury remains controversial. Technology: We developed a minimally invasive technique combining biocompatible screw–based hindfoot biomechanical alignment correction with Kidner surgery. A biocompatible…
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Artikel Jurnal
Progress of computational biomechanical modelling for calcaneal fracture fixation
Background: Calcaneal fractures are among the most disabling and costly orthopaedic injuries, frequently requiring surgical fixation via open reduction and internal fixation (ORIF) or minimally invasive fixation (MIF). Finite element (FE) analysis is an increasingly critical in silico tool for…
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Artikel Jurnal
Integrated strategy of collagen fiber arrangement-inspired magnetic nanochain-doped ordered biphasic scaffold and gradient magnetic field stimulation for osteochondral regeneration
Background: Osteochondral defects pose significant clinical challenges owing to the complex anisotropic collagen alignment of osteochondral tissue and its limited self-healing capacity. Although mechanically biomimetic scaffolds have been widely applied in osteochondral repair, existing scaffolds…
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Integrated tardigrade-based biomimetic strategy and stem cell expansion and differentiation for a novel radioprotection approach
Background: Tardigrades have attracted widespread research attention due to their extraordinary radiotolerance, of which the damage suppressor protein (DSUP) is regarded as a key molecule responsible for their robust DNA repair capability. How to translate these findings into safe and efficacious…
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Artikel Jurnal
Decellularized extracellular matrix: Advanced bioplatforms for functional tissue restoration via innovative decellularization techniques
Background: In recent years, tissue engineering has experienced rapid development, with bioscaffolds emerging as a focal point of research due to their favorable bioactivity, biocompatibility, and capacity to provide mechanical support for cellular growth. The bioscaffolds have great potential in…
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Barcode screening reveals the key role of gold nanoparticle morphology in tumor targeting
Currently, nanoparticles (NPs) still face challenges in achieving efficient tumor targeted delivery, especially in balancing in vivo distribution and cellular uptake efficiency. A recent study published in Advanced Functional Materials utilized DNA barcoding combined with high-throughput in vivo…
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Artikel Jurnal
The biological association between programmed cell death function and osteoarthritis using multi-omic Mendelian Randomization
Background: Osteoarthritis (OA) is a degenerative joint disorder influenced by genetic, molecular, and environmental factors. Programmed cell death (PCD) pathways, including apoptosis, pyroptosis, necroptosis, ferroptosis, and autophagy, are linked to cartilage degradation, but their role in OA…
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Artikel Jurnal
Advancing biomimetic bone Scaffolds: From electrospun 2D membranes to functional 3D nanofiber constructs
Advancing beyond traditional electrospun two-dimensional (2D) membranes, functional three-dimensional (3D) nanofiber constructs represent a transformative approach. Unlike planar 2D structures, these advanced 3D constructs uniquely integrate essential biomimetic nanotopography with hierarchical…