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hLife
Scopus
ISSN 2949-9283 · Elsevier · 94 artikel di indeks
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Artikel Jurnal
Migrasome-driven mitocytosis relieves mitochondrial damage induced by chikungunya virus TF and 6K
Chikungunya virus (CHIKV) infection induces the formation of migrasomes, yet their specific role in CHIKV pathogenesis remains unclear. This study explores the mechanisms underlying mitochondrial damage induced by CHIKV 181 clone 25 (CHIKV 181/25) and the role of migrasomes in mitigating this…
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Artikel Jurnal
One Health surveillance of bat virome in mainland Southeast Asia and adjacent regions
Bats are critical viral reservoirs that harbor viromes with high cross-species transmission risks, yet their virome diversity in the mainland Southeast Asia and adjacent regions remains underexplored. Here, we characterized the bat viromes from 659 samples (197 individuals, 16 species) from Yunnan…
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Artikel Jurnal
Rabies virus glycoprotein: Structure, function, and antivirals
Rabies, a persistent and historic global zoonosis, continues to impose a significant public health burden, particularly in resource-limited regions. The causative agent, rabies virus (RABV; genus Lyssavirus, family Rhabdoviridae), possesses a surface glycoprotein (G) that is pivotal for virus entry…
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Artikel Jurnal
Pan-prediction of major histocompatibility complex class II–restricted epitopes across species via an AlphaFold-based quantification scheme
The high polymorphism of histocompatibility complex class II (MHC-II) alleles and limited immunopeptidomic data hinder pan-species epitope prediction. In this study, leveraging the predictive power of AlphaFold (AF) and the conserved structural features of the core region of MHC-II–binding…
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Artikel Jurnal
Diagnostics for human pathogenic fungal infections: Current status and future prospects
Human fungal infections represent a rapidly emerging global health threat, especially threatening immunocompromised populations, highlighting the urgent need for accurate and timely diagnostic approaches to reduce morbidity and mortality. This review synthesizes recent advances in diagnostic…
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Artikel Jurnal
Berberine alleviates radiation-induced lung injury by promoting microbiota-derived inosine via the gut–lung axis
Radiation-induced lung injury (RILI) is a common complication of radiotherapy. Although berberine (BBR) has been suggested to be associated with reduced RILI incidence, the underlying mechanisms remain unknown. Here, we investigated whether the gut microbiota mediates the radioprotective effects of…
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Artikel Jurnal
A phage-based luminescent reporter platform for rapid typing of multiple capsular types of
Klebsiella pneumoniae is an important opportunistic pathogen, and its capsular polysaccharides are key virulence factors. Capsular typing is important for epidemiological surveillance, clinical diagnosis, and therapy development; however, methods for capsule-targeted detection remain limited. Here…
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Artikel Jurnal
Intranasal gold nanoparticle-antigen induces mucosal and systemic immunity against β-coronaviruses
The continued emergence of diverse beta-coronaviruses (β-CoVs) from animal reservoirs underscores the urgent need for broad-spectrum mucosal vaccines, yet their development is hindered by physiological barriers, rapid antigen clearance, and suboptimal multivalent display strategies. To address…
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Engineering organoids toward implantable living therapeutics
Stem cell-derived organoids are emerging as living therapeutics for repairing or replacing damaged tissues and organs, offering new opportunities for regenerative medicine. However, their clinical translation remains limited by immune rejection, insufficient functional integration, and low…
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Artikel Jurnal
Engineering nasally delivered IgM antibodies for respiratory viral infections
Respiratory viral infections remain a significant global health burden, requiring interventions that establish robust defense directly at the portal of entry. Intranasal delivery of engineered IgM antibodies represents a highly potent platform for achieving mucosal protection. In this review, we…
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Artikel Jurnal
hMPV M2-2 protein modulates host mRNA alternative splicing to favor virus replication
Human metapneumovirus (hMPV) is a widespread and prevalent respiratory pathogen, yet the mechanisms by which hMPV modulates host gene expression to facilitate replication remain incompletely characterized. Here, we systematically profiled hMPV–host protein–protein interactions by affinity…
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Artikel Jurnal
Placental endothelial ferroptosis induced by neutrophil NETosis leads to intrauterine growth restriction in dengue virus infection
Studies on dengue virus (DENV) infection during pregnancy show that symptomatic dengue is associated with adverse fetal outcomes, but the mechanisms remain unclear. Our previous research indicated that neutrophils contribute to intrauterine growth restriction (IUGR) by damaging placental…