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The Journal of Liquid Biopsy
Scopus
ISSN 2950-1954 · Elsevier · 259 artikel di indeks
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Artikel Jurnal
Minimal residual disease combined with radiological tumor volume as a tool for identification of resected NSCLC patients at high risk of recurrence
Introduction: Circulating tumor DNA (ctDNA) is a valuable tool for assessing minimal residual disease (MRD) and predicting recurrence in resected non-small cell lung cancer (NSCLC) patients. Combining ctDNA-detection with radiological tumor volume may improve risk stratification. Methods: Patients…
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Artikel Jurnal
A streamlined hybrid-capture and genome-wide multi-omic platform for highly sensitive ctDNA minimal residual disease monitoring
Background: Circulating tumor DNA (ctDNA) analysis has revolutionized minimal residual disease (MRD) monitoring, but conventional tumor-informed amplicon-based sequencing (AMP) is limited by the narrow variant capacity and diversity. Hybrid capture-based sequencing (HYB) is more versatile and…
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Artikel Jurnal
Circulating MicroRNAs in non-small cell lung cancer: Clinical potential, analytic pitfalls, and barriers to implementation
Background: Neoadjuvant chemoimmunotherapy is standard care for resectable non-small cell lung cancer (NSCLC), yet 70% to 80% of patients do not achieve a pathologic complete response, and no validated biomarker identifies likely non-responders before or during treatment. Circulating microRNAs…
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Artikel Jurnal
A cfDNA fragmentomics-based machine learning model for predicting treatment response and recurrence in locally advanced rectal cancer after neoadjuvant chemoradiotherapy
Neoadjuvant chemoradiotherapy (nCRT) is standard treatment for locally advanced rectal cancer (LARC), but responses vary substantially. We developed Fragmentia-AI Response, a machine learning model that uses cell-free DNA (cfDNA) fragment features to predict pathological response and recurrence…
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Artikel Jurnal
Beyond variant detection: Mismatch repair gene alterations in plasma cell-free DNA from 1,226 glioma samples, and plasma-confirmed functional deficiency in an unbiopsied pontine glioma
Background: Mismatch repair (MMR) gene alterations are uncommon in glioma but can produce hypermutation and sensitivity to checkpoint inhibition. Profiling is often unavailable in diffuse intrinsic pontine glioma (DIPG), where biopsy carries substantial risk. We assessed whether plasma cell-free…
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Artikel Jurnal
Cerebrospinal fluid circulating tumor DNA profiling in central nervous system metastases from solid tumors: A prospective multicentre translational analysis of the BrainStorm (OncoDistinct-006) study
Background: Central nervous system (CNS) metastases represent a complication in solid tumors and often harbour unique genomic alterations diverging from those in primary tumor tissue or plasma; however, direct sampling of CNS lesions carries procedural risks, limiting its molecular profiling. The…
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Artikel Jurnal
Storage-dependent changes in the soluble urinary proteome: a pre-analytical stability study in inflammatory clinical urine samples
Urine is a highly accessible biofluid for clinical proteomics, but pre-analytical variability during collection, storage, and processing can compromise reproducibility. Mass spectrometry–based proteomics enables broad measurement of urinary proteins, making it suitable for evaluating how storage…
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Artikel Jurnal
Comparative diagnostic value of a blood-based three-gene DNA methylation assay and a seven-autoantibody panel for differentiating pulmonary nodules
Background: Low-dose CT has increased pulmonary nodule detection, but noninvasively distinguishing benign from malignant nodules or early lung cancer remains difficult. Blood-based DNA methylation and tumour-associated autoantibody assays may complement imaging. Methods: This combined prospective…
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Artikel Jurnal
Application of PathoChip to urine-derived nucleic acids for broad microbial profiling in men with suspected prostate cancer: setup of a methodological workflow and pilot feasibility study
Background: Urine-based liquid biopsy is an attractive non-invasive source of prostate cancer (PCa) biomarkers, but urinary microbiome studies have mainly relied on 16S rRNA sequencing or shotgun metagenomics. This pilot study optimized and evaluated a practical workflow using PathoChip – a…
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Artikel Jurnal
Clinico-genomic risk stratification for biomarker-enriched trial design in poor-prognosis metastatic castrate-resistant prostate cancer (mCRPC)
Background: An integrated prognostic risk-score (RS) based on prognostic clinical factors and plasma copy number alterations (CNAs) across independent metastatic castration-resistant prostate cancer (mCRPC) cohorts was applied as a classifier to guide development of biomarker-enriched clinical…
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Artikel Jurnal
Liquid biopsy in oncology practice: A global survey by the Young Committee of the International Society of Liquid Biopsy (ISLB)
Background: Liquid biopsy is a transformative tool for precision oncology, yet its clinical use remains variable across healthcare systems, and barriers to its implementation are poorly characterized. This survey aims to assess perceptions and practices related to liquid biopsy in oncology practice…
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Artikel Jurnal
Impact of methodological variability on the prognostic performance of circulating tumor DNA in colorectal cancer: A systematic review and meta-analysis
Circulating tumor DNA (ctDNA) has demonstrated utility for treatment monitoring, risk stratification, and prognostication in colorectal cancer (CRC). However, substantial methodological heterogeneity across studies may influence its reported prognostic performance. Here, we systematically searched…
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Artikel Jurnal
A novel imaging-based approach for large extracellular vesicle detection and prognostic stratification in metastatic breast cancer
Background: Large extracellular vesicles (LEVs) are membrane-bound extracellular particles released by tumour cells into body fluids. Circulating LEVs carry tumour-associated biomaterials and are more abundant than circulating tumour cells (CTCs), representing a valuable liquid biopsy analyte. We…
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Artikel Jurnal
Early tumor-informed circulating tumor DNA (ctDNA) dynamics correlate with response to first-line advanced NSCLC treated with pembrolizumab ± chemotherapy
Background: Immune checkpoint inhibitors (ICIs), alone or combined with chemotherapy, constitute the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) without actionable oncogenic drivers. However, radiologic response assessment has limitations in capturing early…
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Artikel Jurnal
A serum-clinical composite model for prostate cancer diagnosis: multicenter validation and CRISPR/Cas13a-based detection
Background: Avoidable prostate biopsies remain a persistent weakness of prostate specific antigen (PSA)- and imaging-led prostate cancer (PCa) diagnosis. The key need is a non-invasive test that improves pre-biopsy risk stratification while remaining potentially translatable to clinical deployment…
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Artikel Jurnal
Circulating tumor cells predict early skeletal-related events in patients with bone metastases from breast cancer
Background: Bone metastases and following skeletal-related events (SREs) are frequent in metastatic breast cancer (MBC) and are a major cause of disability. Circulating tumor cells (CTCs) are prognostic in MBC and are more frequent in patients with bone metastases (BMs). We investigated whether…
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Artikel Jurnal
Associations between early changes in circulating tumor DNA (ctDNA) and outcomes across randomized trials: Insights from the ctMoniTR project
Background: Circulating tumor DNA (ctDNA) dynamics have emerged as a promising biomarker of treatment response in oncology drug development. Early decreases in ctDNA levels after treatment initiation are associated with improved long-term outcomes in patients with advanced cancer. To be considered…
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Artikel Jurnal
Sex hormone balance and PSA-derived biomarkers in cancer-free African migrant men in Italy: Implications for prostate cancer early detection
Background: Men of African ancestry experience a disproportionate burden of prostate cancer (PCa), with higher incidence and mortality than men of European ancestry. Although social determinants of health, barriers to care, and delayed diagnosis are key contributors to these disparities, ancestry-…
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Artikel Jurnal
A workflow for assessing antibody-drug conjugate target expression on circulating tumour cells from triple-negative breast cancer and epithelial ovarian cancer patients
Background: Antibody–drug conjugates (ADCs) are transforming the therapeutic landscape of solid tumours. Both patient selection and ADC efficacy in triple-negative breast cancer (TNBC) and epithelial ovarian cancer (EOC) are impacted by target antigen expression, which is often heterogeneous…