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Journal of Physiological Investigation
Scopus
ISSN 2950-6344 · Wolters Kluwer Medknow Publications · 99 artikel di indeks
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Artikel Jurnal
Very Low-density Lipoprotein-triacylglyceride Promotes Hepatitis B Virus Reactivation
Metabolic dysfunction-associated steatotic liver disease (MASLD) inhibits hepatitis B virus (HBV) activity while simultaneously exacerbating liver fibrosis/cirrhosis (LF/LC) in chronic HBV (CHB)-infected patients. To date, no model is available to investigate this discrepancy. The established…
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GYT-088 Restores Endothelial Function and Prevents Retinal Vascular Pathology in Non-proliferative and Proliferative Diabetic Retinopathies
Diabetic retinopathy remains a leading cause of vision impairment worldwide, with early stages characterized by endothelial dysfunction and later stages marked by pathological neovascularization. Although intravitreal antivascular endothelial growth factor (VEGF) therapies are effective in advanced…
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Natural Defense against Atherosclerosis: The Therapeutic Potential of Torenia concolor Lindley var. Formosana Yamazaki Extract in Inhibiting the Formation of Macrophage-derived Foam Cells
We previously reported that the ethanolic extract of Torenia concolor Lindley var. formosana Yamazaki (TCEE), a plant native to Taiwan, protects against endothelial dysfunction and atherosclerosis. However, its effects on macrophage-derived foam cell formation and the underlying regulatory…
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Pectolinarigenin Induces Mitochondrion-dependent Apoptosis, Causes G2/M Arrest, and Inhibits Migration and Invasion in Rheumatoid Arthritis–Fibroblast-like Synoviocytes
Pectolinarigenin (PEC), a bioactive flavonoid extracted from Cirsium japonicum, demonstrates anti-inflammatory and anticancer properties with potential to inhibit the tumor-like invasion of rheumatoid arthritis–fibroblast-like synoviocytes (RA-FLSs). This study aimed to evaluate PEC’s effects on…
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E2F Transcription Factor 8 Contributes to the Pathogenesis of Alzheimer’s Disease Accompanied with Decreased Expression of Matrix Metalloproteinase-9 and B-cell Lymphoma 2
Evidence suggests that changes in gene expression play an important role in the development and progression of Alzheimer’s disease (AD). Although many genes have already been identified, there are other genes potentially involved in this process but have not been identified. To further investigate…
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Recent Advances in Brucella Detection and Diagnosis: Innovative Applications Based on Surface-enhanced Raman Scattering
Brucellosis, a globally significant zoonosis, demands rapid, accurate diagnostics to optimize therapeutic intervention and containment. Traditional detection methods face critical limitations, including poor discrimination between acute and past infections and lengthy testing times. In recent…
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Shikonin Alleviated Epithelial Responses in a Lipopolysaccharide/Tumor Necrosis Factor Alpha-induced Ulcerative Colitis-like Condition in Caco-2/HT-29 Co-cultured Cells by Modulating the MAPK/NLRP3/Nuclear Factor Kappa B Pathways
Shikonin (SK), the primary bioactive compound extracted from Lithospermum erythrorhizon Siebold and Zucc. roots, exhibits anti-inflammatory, wound healing, and anticancer bioactivities. Ulcerative colitis (UC) is a chronic inflammatory intestinal condition with an unclear cause. This study…
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Host-mediated Remodeling of the Gut Microbiota in Energy Homeostasis and Environmental Resilience
The gut microbiome dynamically regulates mammalian energy homeostasis by remodeling its composition to optimize nutrient extraction and persistence, often exacerbating obesity under energy-rich diets through disruption of host intake–expenditure balance. For instance, phylum-level dynamics like…
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Effects of Iron Supplementation during the Menstrual Period on Hemoglobin Levels and Fatigue in Female Athletes
Athletic training and menstruation both contribute to iron depletion and anemia in female athletes. We hypothesized that oral iron supplementation during the menstrual period would increase the hemoglobin (Hb) level and reduce fatigue in female athletes. Twenty-two female athletes were randomly…
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A New Approach to Identifying Potential Biomarkers of Endometrial Cancer Based on Methylation Aberrations
Alterations in DNA methylation are a hallmark in cancer development. This study aimed to obtain accurate methylation measurements as the basis of a package of statistical methods for the identification of biomarkers for endometrial cancer (EC). In this study, regression on correlated probes (RCP)…
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Properties of Nucleotide Pool and Its Relationship with Differentially Expressed Transcriptome and Fibrosis Progression in CCl4-induced Mice
The properties and dynamics of small biomolecule pools of a cell or an organ have a significant effect on the metabolism of the related biomacromolecules and the ongoing life process. Here, we investigated the properties of the nucleotide pool and differentially expressed transcriptome in the liver…
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Hemostatics Attenuate Spinal Vascular Extravasation Following Acute Cervical Cord Contusion in Rats
Spinal injury disrupts spinal vasculature and results in spinal hemorrhage followed by extravasation, which leads to a series of secondary injury cascades. Prevention of spinal hemorrhage and extravasation following spinal injury is a key therapeutic target. The present study evaluated the…
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Effect of 17α-ethinylestradiol on the Secretion of Corticosterone in Male Rats
The 17α-ethinylestradiol (EE2) is a derivative of estradiol, which has been used to be the oral contraceptive pills. EE2 is an environmental hormone and influences the endocrine system in animals. In the present study, we explored the mechanism of EE2-modulatory corticosterone production in vitro…
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Sex and Age Differences in Apoptosis in the Developing Mouse Hippocampus and Cerebral Cortex
Programmed cell death, or apoptosis, is a critical mechanism contributing to the development of sex differences in cell number within specific regions of the vertebrate brain. While apoptosis has been previously documented in the developing mouse hippocampus and cerebral cortex, detailed analyses…
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Lipid Nanoparticle Encapsulated Chemotherapeutic Drugs Quantitation In vivo using Liquid Chromatography-coupled Electrospray Ionization Tandem Mass Spectrometry
Systemic chemotherapeutic drugs such as paclitaxel (PAC) and lenvatinib (LEV) are widely utilized in the treatment of solid tumors. Although their pharmacological detection methods have been well documented, the growing interest in lipid-based nanoparticle (LNP) delivery systems necessitates the…
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Antinociceptive Interaction between Diclofenac and Statins: An Isobolographic Analysis
Most of the available pharmacological strategies of pain relief use drugs that have monomodal mechanisms of analgesia. However, pain treatment requires combinations of drugs with nonredundant mechanisms of action to improve pain management and reduce the adverse effects produced by high doses of…
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Tight Junction Regulation in Blood–Brain Barrier Integrity and Neurological Diseases
Through controlling the flow of molecules between the circulation and the brain, the blood–brain barrier (BBB) maintains homeostasis in the central nervous system (CNS). Crucial for sealing endothelial cell connections and maintaining BBB integrity are tight junctions (TJs), which are composed of…
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Deep Learning Technology in Genomics, Radiotherapy, and Ophthalmology for Precision Medicine
Precision medicine (PM) represents a paradigm shift in health care – moving from generalized treatment toward individualized care informed by each person’s genetic, environmental, and lifestyle profile. The advent of artificial intelligence (AI) and deep learning (DL) has accelerated this…
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Digital Medicine in Neuropsychiatry: Prospects, Applications, and the Emerging Framework of Precision Psychiatry
Neuropsychiatric disorders, including schizophrenia, major depressive disorder, and bipolar disorder, are major contributors to global disability, yet their diagnosis and treatment still largely rely on subjective symptom-based classifications. The recent breakthroughs in artificial intelligence…