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International Journal of Pharmacy & Integrated Health Sciences
ISSN 2958-1656 · Superior University Lahore, Pakistan · 146 artikel di indeks
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Artikel Jurnal
IN-SILICO APPROACH FOR PREDICTING HUMAN MICRORNA TARGETS AGAINST DENGUE VIRUS
Background: MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression and play critical roles in the host immune response and viral pathogenesis. Dengue virus (DENV), a mosquito-borne pathogen, remains a major public health concern worldwide. Objectives: This study aimed to…
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A PHYTOCHEMICALS AND ANTI-TUBERCULOSIS POTENTIALS OF ANOGEISSUS LEIOCARPUS AND BALANITES AEGYPTIACA EXTRACTS
Background: Tuberculosis (TB) continues to be a major global health challenge, driving the ongoing search for alternative therapeutic agents, particularly from medicinal plants. Objectives: This study aims to evaluate the extraction yields, phytochemical profiles, and antimycobacterial activities…
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DEVELOPING SYNERGISTIC THERAPEUTIC STRATEGY TO UNCOVER ENHANCED ANTI-TUMOR EFFICACY IN HIGH-GRADE SEROUS OVARIAN CARCINOMA (HGSOC)
Background: The most deadly gynecological malignancy has a late-stage diagnosis, fast progress, and recurrence, called high-grade serous ovarian carcinoma (HGSOC). The clinical conclusion now requires innovative therapeutic approaches. Objectives: In this study, the anticancer properties of…
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ANALYSIS OF THE THERAPEUTIC EFFICIENCY OF VONOPRAZAN AND ESOMEPRAZOLE FOR TREATING GASTROESOPHAGEAL REFLUX DISEASE (GERD)
Background: Proton pump inhibitors (PPIs) like esomeprazole (ESMP) are first-line therapies for acid-related symptoms in GERD. However, potassium-competitive acid blockers (PCABs) such as Vonoprazan (VPZ) are emerging alternatives. Comparative data on symptom relief and adverse drug reactions…
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COMPREHENSIVE UPDATE ON ANTICANCER HERBS: ETHNOBOTANICAL INSIGHTS, PHYTOCHEMICAL PROFILES AND EXPERIMENTAL VALIDATION
Cancer continues to pose a serious public health problem globally, and ongoing research into other therapy modalities has included the utilization of botanicals from traditional medicine. Objective: This review systematically compiles and critically evaluates herbs traditionally used in cancer…
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POST-OPERATIVE PAIN CONTROL MEDICATIONS PRESCRIBED ON DISCHARGE AFTER LAPAROSCOPIC CHOLECYSTECTOMY AND GYNECOLOGICAL LAPAROSCOPY IN HAZARA DIVISION, PAKISTAN
Background: Appropriate discharge medication is essential for adequate postoperative pain control and prevention of complications in day-care surgical procedures. This study evaluated the discharge medication practices of the Day Surgery Unit (DSU) for patients undergoing cholecystectomy and…
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Artikel Jurnal
IN SILICO APPROACH TO PREDICT HUMAN-DERIVED MIRNA TARGETS AGAINST COVID-19
Background: MicroRNAs (miRNAs), small noncoding RNAs, regulate gene expression and play a crucial role in antiviral defense. Computational tools, including RNA22, RNAhybrid, and miRanda, were used to predict miRNA–mRNA interactions and identify human miRNAs with potential activity against the…
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TRANSITION METAL PIPERATES: SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITIES
Background: The chemistry and efficacy of metal complexes have been investigated extensively since the start of the 20th century, and various methods of synthesis have also been studied to prepare effective metal coordination complexes. Objectives: The current study was conducted to prepare metal…
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OXIDATIVE STRESS–MEDIATED BIOMOLECULAR DAMAGE AND THE ROLE OF ENDOGENOUS AND PLANT-DERIVED ANTIOXIDANTS
Background: Oxidative stress is the result of the imbalance between the generation of reactive oxygen species (ROS) and free radicals (FRs) and the ability of the body’s antioxidant defense system to counteract these. The primary forms of ROS are superoxide anion, hydrogen peroxide, and hydroxyl…
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EXPLORING PRODRUG STRATEGIES FOR IMPROVED DRUG DELIVERY, AND THERAPEUTIC OUTCOMES: A COMPREHENSIVE REVIEW
Background: The successful transformation of a promising drug candidate into an effective and patient-friendly therapeutic product remains a significant challenge in pharmaceutical development. Many drugs exhibit poor aqueous solubility, limited bioavailability, rapid elimination, undesirable…
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DEISGN AND ASSESSMENT OF A EUGENOL MUCOADHESIVE BUCCAL PATCH FOR THE TREATMENT OF PERIODONTAL DISEASE
Background: Periodontitis (PD) is a chronic inflammation of periodontal tissues associated with significant pain. PD is a progressive disease with an elevated prevalence reported in the adult population above 30 years of age. Eugenol (EUG), a phenolic compound extracted from clove (Eugenia…
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CRISPR–CAS9 IN DRUG DISCOVERY AND PHARMACEUTICAL DEVELOPMENT: MECHANISMS, APPLICATIONS, AND TRANSLATIONAL CHALLENGES
Background: The CRISPR-Cas9 system has transformed biomedical research by enabling precise and programmable genome editing. Beyond basic research, CRISPR-Cas9 has emerged as a powerful tool for drug discovery, target validation, and therapeutic development. Objectives: This narrative review aims to…
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A COMPARATIVE STUDY OF ORAL IRON SUPPLEMENTS IN ANEMIA DURING PREGNANCY: A PROSPECTIVE OBSERVATIONAL COHORT STUDY
Background: Iron deficiency anemia is a major public health concern during pregnancy and is associated with adverse maternal and fetal outcomes. Although several oral iron preparations are available, comparative evidence on their effectiveness in improving red blood cell (RBC) indices in pregnant…
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A NARRATIVE REVIEW EXPLORING NATURAL PIGMENTS, BIOACTIVE COMPOUNDS, ENZYMES, AND NUTRACEUTICALS DERIVED FROM NATURAL SOURCES
Background: Natural products derived from microorganisms and plants offer sustainable and eco-friendly alternatives to synthetic products, with growing applications across health, food, pharmaceutical, and other industries. Objective: This review provides a comprehensive examination of natural…
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KNOWLEDGE, ATTITUDE, AND PRACTICES REGARDING DENGUE FEVER PREVENTION AMONG SCHOOL AND COLLEGE STUDENTS IN LAHORE, PAKISTAN
Background: Dengue fever remains an important public health concern in Lahore due to recurrent outbreaks. Understanding students' knowledge, attitudes, and practices (KAP) is essential for strengthening dengue prevention. Objectives: This study aimed to assess knowledge, attitudes, and preventive…
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INTEGRATED COMPUTATIONAL PROFILING OF CHOLINERGIC COMPOUNDS TARGETING ACETYLCHOLINESTERASE: MOLECULAR DOCKING, ADMET AND DFT INSIGHTS FOR ALZHEIMER'S DISEASE
Background: Acetylcholine (ACh), a key neurotransmitter in the cholinergic system, plays a crucial role in muscle contractions, arousal, and memory. Dysregulation of acetylcholinesterase (AChE), the enzyme responsible for hydrolyzing ACh, is implicated in neurodegenerative diseases such as…
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Artikel Jurnal
AI-INTEGRATED PHARMACY INFORMATICS SYSTEMS: PRESENT IMPACT AND FUTURE POTENTIAL
Background: The rapid advancement of computational power and artificial intelligence (AI) research has accelerated the adoption of AI-based technologies across healthcare. In pharmacy informatics, AI has emerged as a promising tool for drug dispensing, patient data analysis, individualized therapy…
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TRANSFUSION SAFETY AND PHARMACOTHERAPEUTIC MANAGEMENT OF Β-THALASSEMIA MAJOR: A MIXED-METHODS STUDY FROM PAKISTAN
Background: β-Thalassemia major represents a significant healthcare burden in Pakistan, driven by a high national carrier rate and substantial annual disease incidence. Transfusion-transmitted infections (TTIs) and secondary complications constitute major contributors to morbidity and mortality in…
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ARTIFICIAL INTELLIGENCE (AI) IN PHARMACEUTICAL SCIENCES: REDEFINING DISCOVERY, DEVELOPMENT, AND PATIENT SAFETY
INTRODUCTION Pharmaceutical sciences have evolved alongside scientific advances that have enabled researchers to address complex questions, explore new ideas, and solve practical challenges. Today, artificial intelligence (AI) is emerging as one of the most transformative technologies shaping the…
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STUDY OF VARIOUS SOLID DISPERSION TECHNIQUES FOR THE SOLUBILITY ENHANCEMENT OF CURCUMIN
Background: Curcumin possesses well-documented pharmacological and therapeutic properties; however, its clinical utility is limited by poor aqueous solubility, which impairs drug absorption and results in low bioavailability and subtherapeutic responses. Objective: This study aimed to enhance…