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BioMed Target Journal
ISSN 2960-1428 · QAASPA Publisher · 46 artikel di indeks
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Artikel Jurnal
Purification and Characterization of Proteases from Pleurotus eryngii
Of all the microbial enzymes, protease is the most valuable owing to its multifaceted industrial applications. Its ability to break down organic waste makes it most significant in industries including food, leather, and waste management. Here purification and characterization of proteases from…
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Artikel Jurnal
Green Artificial Intelligence: A Comprehensive Review of Energy-Efficient Strategies, Frameworks and Pathways Toward Reducing AI Carbon Footprints
The rapid growth of artificial intelligence, especially deep learning and machine learning models, has contributed to transformative innovation across many industries. The rapid technological advancement in AI research and its applications is increasingly drawing the focus to the sustainable…
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Artikel Jurnal
SERPINA1 and Alpha-1 Antitrypsin: A Review of Molecular Structure, Clinical Variants and Computational Study of Diseases Involving the Protein
The SERPINA1 gene, located at 14q31-32.3, is responsible for producing Alpha-1 Antitrypsin (AAT), which acts as a serine protease inhibitor to protect tissues from any proteolysis-induced damage. The genetic mutations of SERPINA1 result in Alpha-1 Antitrypsin Deficiency (AATD), a condition…
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Artikel Jurnal
Neurobiological and Micronutrient Mechanisms in Pica Syndrome
Pica syndrome is a complex eating disorder characterized by persistent consumption of non-nutritive substances with significant clinical consequences. This review critically evaluates the neurobiological and micronutrient mechanisms proposed to underlie the disorder. A narrative, non-systematic…
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Artikel Jurnal
Analysis of Mutations in the Receptor Binding Domain of Spike Protein of SARS-CoV-2 in Borno State, Nigeria, and its Effect on Antigenic Properties
The high mutation rate and RNA nature of SARS-CoV-2 drive rapid evolution, emphasizing the pivotal role of inhibiting viral interaction with host cells for pharmaceutical intervention. The study aimed to assess the influence of mutations on the receptor-binding domain (RBD) of the Spike…
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Artikel Jurnal
ZEB2 at the Crossroads of Development and Cancer Hallmarks: Integrating Experimental Evidence with in silico Analyses
ZEB2 is a pivotal transcriptional controller which lies at the interface between developmental biology and cancer molecular signatures. In addition to its classical role in the epithelial-mesenchymal transition (EMT), ZEB2 controls immune modulation, stemness, angiogenesis, and therapeutic…
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Artikel Jurnal
Systemic Redox Imbalance is Reflected by Altered Serum Oxidative and Antioxidant Biomarkers in Patients with Osteonecrosis
This comparative clinical study investigates the relationship between oxidative stress and osteonecrosis. The aim was to evaluate the balance between oxidative stress and antioxidant defenses by analyzing serum levels of key biomarkers in 45 patients with osteonecrosis and 45 age- and sex-matched…
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Artikel Jurnal
Prevalence and Associated Factors of Early Childhood Caries: A Cross-Sectional Study among Syrian Refugee Children in Erbil Camps
Early Childhood Caries (ECC) is a significant global health issue affecting children under six years old. Refugee children are particularly vulnerable due to limited access to healthcare. This study assessed the prevalence of ECC and explored sociodemographic, dietary, and behavioral factors…
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Artikel Jurnal
GLP-1 Receptor Agonists: Advances in Mechanism, Therapeutic Applications, and Future Perspectives
Worldwide prevalence of type 2 diabetes mellitus (T2DM) and obesity has heightened the need to find treatments that control hyperglycemia, together with weight gain and resultant organ damage. Under this arrangement, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as…
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Artikel Jurnal
Prevalence and Sociodemographic Determinants of Helicobacter pylori Infection Among Peptic Ulcer Patients
Helicobacter pylori (H. pylori) infection remains a pressing public health issue in low- and middle-income countries (LMICs), with sub-Saharan Africa carrying a significant share of the global burden. Despite its prevalence, region-specific data are still lacking across many parts of Nigeria. This…
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Artikel Jurnal
Pan-Cancer Analysis of ABCA3: Insights into Prognosis, Epigenetic Regulation, and Immune Microenvironment
The ATP-binding cassette subfamily A member 3 (ABCA3) gene encodes a transmembrane protein that facilitates lipid transport and regulates lung surfactant levels. The gene functions as a tumour suppressor, but its involvement in different cancer types has not been fully elucidated. This study…
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Artikel Jurnal
The Emerging Role of In Silico Approaches in Understanding UBE3A and Its Neurological Implications
Ubiquitin Protein Ligase UBE3A, which is located on chromosome 15q11–13, is neuron-specifically imprinted and is crucial for brain development and synaptic function. Disruptions in UBE3A gene expression are linked with multiple crucial neurodevelopmental complications, such as Angelman syndrome…
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Artikel Jurnal
Genetic Susceptibility to Type 2 Diabetes Mellitus Linked to TCF7L2 Rs7903146 Variant in a Northern Nigerian Population
Polymorphisms in the gene encoding transcription factor 7-like 2 (TCF7L2) have been identified as potent genetic risk factors for the development of type 2 diabetes mellitus (T2DM) and its associated complications. This study aimed to investigate the association between the rs7903146 (C/T)…
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Artikel Jurnal
Mindfulness Interventions in Managing Paranoia: A Scoping Review
Paranoia is a prevalent symptom in various psychiatric conditions, presenting a challenge for conventional treatment methods. Mindfulness-based interventions (MBIs) offer a promising alternative, yet their efficacy in treating paranoia needs thorough exploration. This study aimed to evaluate the…
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Artikel Jurnal
Role of the Modified WHO Partograph in Improving Maternal and Neonatal Outcomes: A Prospective Observational Study
Childbirth requires close monitoring to ensure maternal and infant safety. Effective labor monitoring helps detect complications early, reducing risks. In 2017, WHO reported 295,000 maternal deaths, mostly in low- to middle-income countries, highlighting the need for improved care. The WHO…
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Artikel Jurnal
Comparing Diagnostic Efficacy of Pap Smear, Liquid-Based Cytology and HPV DNA in Cervical Cancer Screening
This study aimed to compare the efficacy of conventional Pap smears with liquid-based cytology (LBC) in screening for cervical cancer. It also studied the presence of HPV (human papillomavirus) infection, and its diagnostic accuracy to predict cervical carcinoma was also studied. The study was…
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Artikel Jurnal
Rare Homozygous CTSC Deletion in Siblings with Papillon-Lefevre Syndrome: A Case Report
Papillon-Lefevre syndrome (PLS) is an extremely rare autosomal recessive genodermatosis caused by mutations in the cathepsin C (CTSC) gene. It is characterized by palmoplantar keratoderma (PPK), periodontopathy, intracranial calcifications, and recurrent pyogenic infections. We encountered an…
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Artikel Jurnal
Trends and Medical Indications of Cesarean Section in the Public Health Sector
Cesarean section is a common obstetric intervention used to save the lives of women and newborns during childbirth-related complications. Its prevalence has risen significantly worldwide in recent years. Understanding cesarean section rates and indications is crucial for evaluating this widespread…
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Artikel Jurnal
Development and Validation of an AI-Based Risk Prediction Model for Osteoporosis in Post-Menopausal Women
Osteoporosis is a leading cause of morbidity in postmenopausal women. Timely risk stratification remains challenging despite available screening tools. The aim is to develop and validate an AI-based predictive model for osteoporosis in postmenopausal women. A hybrid approach combining clinical…
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Artikel Jurnal
Next-Generation Computational Approaches for Biological Network Analysis
Protein-protein interaction (PPI) networks are critical to understanding cellular processes and disease mechanisms. Computational advances have transformed PPI analysis, allowing for the prediction, analysis, and visualization of intricate interaction networks. This article discusses the basics of…