49 results

Co-formulation of IL-12 mRNA and doxorubicin in polymeric nanoparticles for simultaneous delivery in murine melanoma

Elina Tanskanen; Hongning Sun; Kai-Chun Cheng et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Liposomal or polymeric nanoparticles have been instrumental in improving the delivery of poorly soluble chemotherapeutics and those with dose limiting toxicity such as doxorubicin (DOX). More recently, nanoformulations have been shown to enable simultaneous delivery of emerging biomolecules such as…

Particle size governs retinal bioavailability of polymeric nanoparticles after non-invasive topical administration

Gitika Kumari; Sourabh Kundu; Jagtar Singh et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

The complex structural and physiological ocular barriers cause hurdles for the permeation and intraocular retention of topically administered drugs. The exploration of intraocular routes of administration partially improved bioavailability. However, such invasive injections caused severe…

Mast cell agonism for glioblastoma immunotherapy

Sophie E. Mendell; Elizabeth G. Graham-Gurysh; Ryan N. Woodring et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Glioblastoma (GBM) is a devastating disease with an effective mortality rate of 100%. Despite decades of research, treatment advances remain relatively stagnant. However, immunotherapeutic strategies, particularly those targeting innate immunity, are increasingly showing some preclinical success…

Nose-to-brain delivery of IRX4204 by cell-adhesion peptide-functionalized gemini surfactant-phospholipid nanoparticles

Antoine Hakim; Gracious D. S. Kasheke; George S. Robertson et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Efficient delivery of hydrophobic therapeutics to the central nervous system (CNS) remains challenging due to poor solubility, limited blood–brain barrier permeability and systemic toxicity. Here, we report the development of gemini surfactant-phospholipid nanoparticles (GPNPs) for intranasal…

Restoration of tumor suppression and improved anticancer efficacy following nanoparticles-mediated combined anti-miRNA 21 and 5-fluorouracil therapy in colorectal cancer

Ahmed Abosalha; Paromita Islam; Stephanie Makhlouf et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

RNA interference (RNAi), particularly through microRNA (miRNA), has emerged as a powerful therapeutic strategy for modulating genetic disorders by precisely targeting and degrading specific mRNA transcripts. 5-Fluorouracil (5-FU) is a fundamental chemotherapeutic agent in the treatment of…

Nanophotobody-mediated EGFR targeting using lignin nanoassemblies enhances photodynamic efficacy in breast cancer

Kshitij Rawat; Prakash Y. Khandave; Yeddula Nikhileshwar Reddy et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Photodynamic therapy (PDT) has emerged as a promising approach for cancer treatment, but its clinical translation is often limited by insufficient target specificity. To address these challenges, antibody-mediated targeting strategies combined with nanoparticle-based photosensitizer delivery have…

Development, characterization and preclinical evaluation of a formononetin derivative phospholipid complex for improved anticancer activity

Neha Bhardwaj; Nabab Khan; Navneet Thakur et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Cancer continues to pose a significant global health challenge, highlighting the need for more effective therapeutic interventions. In this study, we have developed a phospholipid complex of FMN-4Morpho, an ester derivative of formononetin (FMN) synthesized with 4-morpholinecarbonyl chloride, to…

Ion-triggered nasal formulation to improve brain resilience against neurodegenerative disorders

Manu Sharma; Priyanka Patra; Sheelu Sharma

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Neurodegenerative disorders are progressive neurological conditions characterized by cognitive deterioration, memory impairment, and behavioral disturbances. Current pharmacological treatments offer only symptomatic relief and are often limited by poor brain bioavailability and systemic side…

Cellulose and its derivatives: understanding physicochemical properties and their applications in pharmaceutical formulations

Noman Ahmad; Peter Timmins; Barbara R. Conway et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Cellulose, the most naturally abundant biopolymer, continues to attract considerable scientific and industrial interest due to its renewability, biodegradability, and diverse physicochemical properties. As a structural polysaccharide found across a range of botanical and microbial sources…

Ultrasound-triggered release of an active Wnt signalling agent (6-bromoindirubin-3-oxime) from perfluorocarbon nanodroplets

Anastasia Polydorou; Qiang Wu; Aya Ben Issa et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Ultrasound-activated perfluorocarbon nanodroplets (NDs) have potential as circulating agents for non-invasive, targeted drug delivery. NDs can be induced to cavitate under focussed ultrasound stimulation, releasing a therapeutic payload. They have been explored widely as a means of drug delivery in…

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RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

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Development and application of PEG-based hydrogels by loading Asparagus racemosus-mediated silver nanoparticles for enhancing in vivo wound healing abilities

Gouhar Jahan Ashraf; Suraj Mistri; Ankrita Thapa et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

The objective of this study was to prepare silver nanoparticles (AgNPs) from the aerial parts of Asparagus racemosus Willd. using the green synthesis method, followed by their incorporation into hydrogel (HG) formulations to enhance their wound healing activity. The synthesized AgNPs were…

Engineering geniposide-loaded solid lipid nanoparticles for sustained release and induced apoptosis in human lung cancer cells

Saumyadeep Bora; Bhavana Jodha; Raju Vidap et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Geniposide, a promising iridoid glycoside with high antitumour effect against non-small cell lung cancer (NSCLC), suffers from low bioavailability, rapid systemic clearance, and suboptimal tumour accumulation. To overcome these biopharmaceutical obstacles, we developed geniposide-loaded solid lipid…

Quality by design (QbD) driven development of enteric polymer-based nanoparticles of posaconazole: characterization, in vitro release, and pharmacokinetic study

Anjali Giri; Srijita Sen; Atul Pandurang Kumbhar et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

This study aims to develop enteric-polymer-based PSZ nanoparticles (PSZ-NPs) using Eudragit S100 and L100 polymers to enhance their absorption and improve their pharmacokinetic profile. The developed enteric-polymer-based PSZ-NPs exhibited a delayed-release profile, thereby showing improved…

Cubosomal nanoparticles for improved edoxaban bioavailability: overcoming solubility and permeability barriers of a BCS class IV drug

Mohamed Nasr; Sameh Saber; Mahmoud E. Youssef et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Edoxaban (ED), a BCS class IV drug, exhibits restricted oral bioavailability because of its poor aqueous solubility and low intestinal permeability. This study investigated the influence of polyethene-glycol 6000 (PEG)/oleic acid (OA)-modified cubosomal nanoparticles on the oral absorption of ED…

Nanographene oxide enables activity-preserving immobilization and enhanced stability of galactose oxidase

Junyoung Jung; Abhishek Sahu; Giyoong Tae

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Enzyme-mediated generation of reactive oxygen species (ROS) has attracted considerable interest for cancer-related applications. However, the biomedical use of oxidase enzymes is often limited by their intrinsic instability and rapid loss of catalytic activity under physiological conditions. Here…

Trafficking self-assembling small molecules to mitochondria for ferroptosis-mediated cancer cell death

Aratrika Halder; Souma Ghosh; Sekar Anubala et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Mitochondria play a central role in cellular ATP production, glucose metabolism, redox balance, and programmed cell death. Cancer cells reprogram many of these mitochondrial functions to support their uncontrolled growth and survival; hence, mitochondria have emerged as attractive and promising…

Ball milling formation of the metformin–pioglitazone eutectic form by ex situ monitoring: mechanochemical preparation, solid-state characterization, and dissolution profiles determination

Irvin J. Moctezuma-García; Alejandra Núñez-Pineda; Uvaldo Hernández-Balderas et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Pharmaceutical eutectic binary solid forms have received considerable attention in recent years because they can enhance the solubility, dissolution rate, and oral absorption of poorly water-soluble drugs. However, predicting their formation is an ongoing challenge. Herein, the preparation of a…

Comparative evaluation of USP II, USP IV, TIM-2, and the dynamic colon model as surrogates for human colonic drug dissolution

Khushi Khandelwal; Eleanor Jones; Connor O'Farrell et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

This study compares conventional dissolution apparatuses (USP II and IV) with advanced biorelevant models (TIM-2 and the Dynamic Colon Model, DCM) for assessing colonic drug dissolution. Theophylline dissolution from modified-release Uniphyllin Continus® tablets was evaluated across varying…

Hapten-conjugated polymeric nanocarriers produced by Flash NanoPrecipitation induce small molecule-specific antibodies in vivo

Mojhdeh Baghbanbashi; Ryan Burnett; David M. Gooden et al.

RSC Pharmaceutics, Vol. 3 No. 5 · 2026 · English · DOAJ Scopus

Vaccines that induce antibodies specific against small molecules are desirable for a range of applications, including as a tool against the opioid epidemic. Many small molecules are not immunogenic due to their low molecular weight, but can be conjugated to larger carriers such as immunogenic…