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Recent Trends in Pharmacology
ISSN 2980-194X · Atatürk University · 40 artikel di indeks
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Artikel Jurnal
Proton Channels in the Context of Human Diseases
Proton channels play an important role in many physiological processes in humans, as in all organisms, since pH determines protonation or deprotonisation state of amino acid residues, thus channel activity, enzyme kinetics, receptor-ligand interactions by changing the surface charges of molecules…
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Artikel Jurnal
Impact of Maintenance Hemodialysis on Quality of Life in the Patients of Chronic Kidney Disease
Objective: Chronic Kidney Disease (CKD) carries a major health burden in India, with hemodialysis patients facing complex therapeutic regimens and impaired quality of life (QOL). This study aimed to evaluate QOL among patients undergoing chronic hemodialysis.Methods: A cross-sectional observational…
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Artikel Jurnal
A Drug Repositioning Approach: Antidiabetic Empagliflozin May Be a Potential Drug for the Treatment of ALS
Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which multiple mechanisms play a role in its pathogenesis. However, no radical treatment is currently available for the disease. The potential for repositioning of the antidiabetic drug empagliflozin, which…
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Thalidomide Modulates Oxidative Stress and Tubular Pathology in Renal Ischemia-Reperfusion in a Timing-Dependent Manner
Background: Renal ischemia–reperfusion (IR) drives acute kidney injury through oxidative stress and inflammation. Thalidomide (TD), an immunomodulatory agent, may attenuate IR-related biochemical and structural damage.Methods: Thirty-two female Wistar albino rats were randomized to four groups…
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Artikel Jurnal
Orlistat-Induced Systemic Adverse Events: A Review of Case Reports And Public Health Implications
Orlistat is a widely used gastrointestinal lipase inhibitor for obesity management. While its efficacy and safety are established under medical supervision, increasing unsupervised use has raised concerns regarding serious adverse events. This review aims to alert healthcare providers to the…
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Therapeutic Music as a Neuroimmune–Metabolic Modulator in NAFLD: A Spleen‑Centered Working Hypothesis
Non-alcoholic fatty liver disease (NAFLD), recently renamed metabolic dysfunction-associated steatotic liver disease, is frequently accompanied by depression and chronic psychological stress that can worsen metabolic dysfunction, promoting NAFLD progression. Given the current limitations of…
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Artikel Jurnal
Loss of Epithelial Intelectin-1 and Altered Epithelial–Stromal Distribution across Colorectal Pathological Conditions
Objective: Intelectin-1 (ITLN1) is an adipokine involved in metabolic and immune regulation, yet its spatial expression and potential contribution to colorectal tumor progression and microenvironmental remodeling remain incompletely understood. This study investigated the expression and spatial…
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Betulinic Acid Mitigates Estrogen Deficiency–Related Femoral Bone Loss: Evidence from an Ovariectomized Rat Model
Objective: Postmenopausal osteoporosis (OP) is characterized by estrogen deficiency–induced bone loss and deterioration of trabecular microarchitecture. Betulinic acid (BA), a natural pentacyclic triterpenoid, has demonstrated antioxidant and osteoprotective properties. This study aimed to evaluate…
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Artikel Jurnal
Protocol Adherence in Spinal Muscular Atrophy Treated with Nusinersen and Risdiplam: A Retrospective Registry-Based Pharmacoclinical Audit
Objective: Disease-modifying therapies such as nusinersen and risdiplam have significantly changed the management of spinal muscular atrophy (SMA). In Spain, both are reimbursed under a national pharmacoclinical protocol with registry-based monitoring. The objective was to evaluate protocol…
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Artikel Jurnal
Is Diabetic Retinopathy (DR) a Lipoxin A4 (LXA4) and Arachidonic Acid (AA) Deficiency Disorder?
Current treatments for DR include photocoagulation, intravitreal injections of anti-VEGF, anti-IL-6 and anti-TNF-α agents and corticosteroids in addition to the control of DM. However, these therapies are ineffective, and vision loss progresses in most patients (2/3). Hence, more effective…
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Artikel Jurnal
Testosterone Replacement Therapy: Indications, Application Protocols, and Side Effect Profile
Testosterone Replacement Therapy has evolved from speculative attempts in the 18th and 19th centuries to the isolation and synthesis of the hormone in the 1930s, followed by the development of different and safer methods of administration throughout the 20th century, leading to today's modern…
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Artikel Jurnal
Vinorelbine- Autophagy Agent Combinations Induce Synergistic Cytotoxicity in SH-SY5Y Neuroblastoma Cells
Objective: To investigate whether pharmacological agents associated with autophagy induction or inhibition modulate vinorelbine-induced cytotoxic responses in SH-SY5Y neuroblastoma cells. Methods: SH-SY5Y neuroblastoma cells were treated with vinorelbine, lithium chloride (LiCl)…
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Artikel Jurnal
A Structure-Based in Silico Study Proposes Glycophorin-E as a Dual Target for Parkinson’s Disease and Alcohol Use Disorder Modulated by Oleuropein (OLE) Glycophorin-E: A Dual Target for PD/AUD via Oleuropein
Objective: Parkinson’s disease (PD) and alcohol use disorder (AUD) have different clinical profiles, but they may share certain molecular weaknesses. This computer-based study explores the new idea that Glycophorin-E (GYPE) could be a common target for both conditions, with the natural compound…
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Artikel Jurnal
Evaluation of the Antidepressant Potential of Triplochiton scleroxylon Leaf Extract Using Tail Suspension and Forced Swim Tests
Objective: Depression is a major neuropsychiatric disorder with a substantial global burden. Existing pharmacotherapies are limited by delayed onset of action, incomplete response, and adverse effects, necessitating the exploration of alternative therapeutic agents, particularly from medicinal…
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Artikel Jurnal
Isolation, NMR Characterization, and Comparative In Vitro Antioxidant Evaluation of Resveratrol from Grape Seeds (Vitis vinifera L.)
Objective: The present study aimed to isolate, characterize, and evaluate the in vitro antioxidant potential of resveratrol from grape seeds (Vitis vinifera L.) obtained from local markets in Erzincan, Türkiye. It is hypothesized that the unique microclimate of that region enhances the bioactive…
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Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line
Objective: This study aimed to evaluate the antiproliferative effects of lacidipine, a dihydropyridine-derived L-type calcium channel blocker, on the human colon cancer cell line (SW480) and the associated changes in inflammatory and oxidative stress markers.Materials and Methods: SW480 cells were…
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The Comparasion of The Effects of Novel Antioxidant Compounds Ebselen, Isorhamnetin, and Genistein on the Cardiovascular System
Purpose: This study evaluated the effects of antioxidants Ebselen (EBS), Isorhamnetin (ISO), and Genistein (GEN) on oxidative stress (OS), hemodynamic parameters, and cardiovascular histopathology in rats.Methods: Forty adult Wistar rats were randomized into four groups (n=8/group): control…
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Tamarindus indica stem bark extract attenuates depression and spatial memory deficits in mice
Title: Tamarindus indica stem bark extract attenuates depression and spatial memory deficits in miceRunning title: Tamarindus indica reversed depression and memory loss in miceAbstractObjective: Depression is a prevalent psychiatric disorder that affects individuals from all walks of life…
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Artikel Jurnal
Unveiling Ecopharmacology: Insights into knowledge, attitude, and practices among medical and nursing students in tertiary care teaching hospital of district Almora, Uttarakhand
Background: Ecopharmacology, a field emerging at the intersection of pharmacology and environmental science, focuses on the impact of pharmaceuticals on ecosystems and public health. Given the increasing recognition of environmental issues associated with pharmaceutical waste, understanding the…
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A randomized controlled trial to evaluate genotyping and therapeutic drug monitoring vs. only therapeutic drug monitoring as a strategy for risk minimization in epileptic patients on carbamazepine therapy
Objective: Carbamazepine (CBZ) is a widely prescribed antiepileptic drug for the treatment of focal seizures. CBZ gets metabolized by cytochrome enzymes mainly CYP3A5. It is difficult to predict clinically whether a patient is likely to suffer from CBZ toxicity. Hence, we planned to evaluate the…