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Gut Microbes Reports
Scopus
ISSN 2993-3935 · Taylor & Francis Group · 105 artikel di indeks
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Artikel Jurnal
In vitro study of ethanol production, ethanol tolerance, and antimicrobial susceptibility of gut microbes associated with liver diseases
Endogenous ethanol (EtOH) production is a newly identified pathophysiological mechanism involved in metabolic dysfunction-associated steatohepatitis (MASH) and liver disease associated with hepatitis B virus (HBV). Therefore, the characterization of EtOH-producing species associated with liver…
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An artificial mucus-integrated in vitro model enables stable live probiotic–host co-culture and recapitulates dynamic hBD-2-mediated antimicrobial feedback
In vitro models for host–microbe interaction often have limited physiological relevance due to the absence of a protective mucus layer, reliance on non-viable bacteria, and short co-culture durations. Here, we present the first scalable and biocompatible in vitro model integrating an artificial…
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Using in vitro gastrointestinal (GI) tract digestive products to investigate fermentation dynamics of Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12, and Escherichia coli
Gastrointestinal digestion shapes nutrient availability and microbial substrates in early life, yet how milk digestion products regulate probiotic–pathogen dynamics remains unclear. Using in vitro digestion products of human milk (HM), infant formula (IF), and control milk (CM), we evaluated the…
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Artikel Jurnal
Distinguishing the significance of blood microbes in epithelial ovarian cancer
The human microbiome has generated growing interest in epithelial ovarian cancer (EOC) research, yet investigations of the blood microbiome remain sparse. This study explored plasma microbial signatures unique to EOC. We accessed 180 age/race/ethnicity-matched archival plasma samples from women…
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Artikel Jurnal
Vpar_1595 encodes malate–lactate transhydrogenase: The first step in lactate metabolism within the genus Veillonella
The genus Veillonella plays a pivotal role in human oral microbiota and biofilm formation. The role of these bacteria is to act as intermediaries, which they do partly by metabolizing L-lactate. Interestingly, their first step in lactate metabolism is catalyzed by malate‒lactate transhydrogenase…
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Fiber-deprived diet weakens lung defense against antimicrobial-resistant Klebsiella pneumoniae and facilitates resistance phenotype in the gut microbiota
The rapid spread of antimicrobial-resistant (AMR) bacteria is a major global health challenge. The misuse of antibiotics and infections by resistant pathogens drive the dissemination of resistance genes, the human microbiota of which serve as reservoirs. Disruptions in the host–microbiota balance…
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Strengths and limitations of in vitro and animal models to advance understanding of human diet‒microbiome interactions
The gut microbiome is a critical mediator of human health. As the intestinal microbiota is far more metabolically diverse than humans, it plays a significant role in the digestion of food, particularly food components that are nutritionally inaccessible to the human host. While no system can fully…
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Artikel Jurnal
Oleoylethanolamide supplementation enriches Akkermansia muciniphila and modulates intestinal barrier function in adults with obesity: A randomized, double-blind, placebo-controlled trial
Targeted modulation of the gut microbiome represents a promising nutritional strategy to support metabolic and intestinal health in overweight and obese adults. Oleoylethanolamide (OEA) is an endogenous lipid mediator that regulates satiety, lipid metabolism, and inflammation, but its effects on…
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Exploring the interplay between dietary plant glycolipids and gut microbiota: A systematic review
Considering the shift towards plant-based diets, it becomes necessary to better understand the roles of plant-derived nutrients in health. Despite their abundance in green plants, the role of plant glycolipids (GLs) in metabolic health remains scarcely known. Gut microbiota is a key actor in the…
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Artikel Jurnal
Species-level virome profiling reveals compositional differences in the gut prokaryotic DNA virome of people with HIV-1 on antiretroviral therapy
Alterations in the gut bacterial communities are well described in people with HIV-1 (PWH). However, less is known about the gut viral communities (virome). Herein, we performed an exploratory study of the gut DNA virome in PWH receiving antiretroviral therapy (PWH-ART). Virome profiling was…
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Investigating the gut microbiota in advanced heart failure and cardiac cachexia
Cardiac cachexia (CC) is associated with advanced heart failure (AHF), characterized by unintentional weight loss (UWL) of fat/muscle. It is exacerbated by right ventricular systolic dysfunction (RVSD). The potential pathogenic role of gut microbiota (GM) changes has not been investigated in CC. We…
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Enterococcus faecalis impairs IGSF9-dependent C1q degradation to accelerate MAFLD-HCC progression
The global increase in metabolic associated fatty liver disease (MAFLD)-related hepatocellular carcinoma (HCC) necessitates urgent investigation of its underlying mechanisms. Our study reveals that high fat diet (HFD)-induced gut dysbiosis enriches Enterococcus faecalis, a potential carcinogenic…
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Infection strategies of Salmonella Typhimurium for gut-lumen colonization: Overcoming host defenses, exploiting host responses, and adapting to the enteric niche
Diarrheal disease is a leading cause of child morbidity and mortality globally, largely resulting from contaminated food and water and exposure to enteric pathogens. Salmonella enterica serovar Typhimurium (STm) is an enteropathogenic bacterium that infects the gastrointestinal tract using diverse…
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Intestinal microbial community assessment in patients with different forms of epilepsy and autoimmune encephalitis: An exploratory study
Despite the availability of antiseizure medications (ASMs), approximately one-third of patients with epilepsy remain refractory to treatment. Evidence suggests that the gut microbiota modulates central nervous system function through neuroimmune and metabolic pathways. We characterized the fecal…
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Gut microbiome dysbiosis and functional alterations in Campylobacter-associated gastroenteritis using metagenomic approaches
Campylobacter species are a major cause of bacterial gastroenteritis worldwide. Using shotgun metagenomic sequencing of stool samples from PCR-confirmed Campylobacter-positive patients and symptomatic PCR-negative controls, we reveal dysbiosis marked by reduced species richness (median Shannon…
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Longitudinal multi-omic dynamics in hospitalized COVID-19 patients based on disease severity
Despite a decline in global COVID-19 cases, severe disease requiring hospitalization remains a significant health burden. Microbial dysbiosis and microbial translocation have been implicated in COVID-19 severity through their contributions to systemic inflammation, yet the temporal dynamics of the…
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Gut microbiota as a driver of variable antihypertensive drug response: A narrative review
Hypertension is a major global burden to human health. Despite the availability of multiple classes of antihypertensive medications, a considerable number of patients still have uncontrolled or treatment-resistant hypertension. The gut microbiota is increasingly recognized as a regulator of blood…
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Oral–gut strain sharing after Roux-en-Y gastric bypass: A canonical oral microbiome signature in the gut linked to hepatic and glycemic remodeling
Roux-en-Y gastric bypass (RYGB) induces durable weight loss and metabolic improvement, but the role of oral microbiota in shaping postsurgical gut ecology and metabolic outcomes is unclear. We examined whether RYGB promotes transfer and expansion of oral strains in the distal gut and how these…
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Gut bacterial O-demethylation in microbiome-dependent drug response
The gut microbiota is recognized as an important contributor to drug metabolism and therapeutic variability. By directly transforming orally administered drugs, gut microbes can influence drug exposure, efficacy, and toxicity. Among these microbial reactions, O-demethylation of methoxy-containing…
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Artikel Jurnal
Assessment of nutrient intake by gut microbiota enterotype in Japanese subjects
Japanese gut microbiota forms community clusters and shares some compositional features with Western enterotypes, although the relationship between enterotypes and habitual nutrient intake in Japanese adults remains unclear. We analyzed data from 770 community-dwelling adults. Enterotypes were…