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Exploration of Cardiology
ISSN 2994-5526 · Open Exploration Publishing Inc. · 125 artikel di indeks
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Is mavacamten superior to aficamten for hypertrophic cardiomyopathy? A frequentist network meta-analysis
Background: Myosin inhibitors have been shown to improve exercise capacity and symptoms, as well as reduce the left ventricular outflow tract (LVOT) gradient. This study explores the efficacy of mavacamten versus aficamten in hypertrophic cardiomyopathy (HCM) patients. Methods: From the inception…
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The diagnostic accuracy of artificial intelligence enhanced electrocardiography for the detection of cardiac dysfunction
Background: Heart failure (HF) remains a growing global health problem, with nearly half of all cases attributed to HF with preserved ejection fraction (HFpEF) and its precursor, left ventricular diastolic dysfunction (LVDD). Although echocardiography is the diagnostic gold standard, its high cost…
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Sudden cardiac arrest in a young patient—a systematic diagnostic journey leading to the diagnosis: case report
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but potentially life-threatening inherited arrhythmia disorder, often presenting in childhood or adolescence. Early and accurate diagnosis is critical, as untreated CPVT carries a high risk of sudden cardiac death, particularly…
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Case report: a giant left ventricular pseudoaneurysm long after blunt chest trauma
Left ventricular pseudoaneurysm is a rare acquired cardiac abnormality that frequently occurs after myocardial infarction or a previous cardiac procedure. Blunt chest trauma accounts for this uncommon entity in sporadic cases. However, this disease does not have any specific clinical findings, so…
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Redesigning local cardiovascular services: an exportable model of hospital–community integration
Redesigning cardiovascular services at the local level is a pressing task for decentralized health systems facing the rising burden of chronic cardiovascular disease. In northern Modena (Emilia-Romagna, Italy), a post-restructuring reorganization exposed the limits of hospital-centric models and…
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Health literacy: application of SAHLPA-18 in patients with acute coronary syndrome
Aim: To evaluate the health literacy (HL) of patients with acute coronary syndrome (ACS) admitted to a public hospital of high complexity in the interior of Minas Gerais, Brazil, through the application of the instrument Short Assessment of Health Literacy for Portuguese Speaking Adults…
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Author’s Reply: The Editor’s role, again
In the editorial game, authors are the players, reviewers are the linesmen on the sidelines, and the editor is the umpire. However, it is not uncommon for the umpire, to have a limited view of the pitch, only to be called back for revision through the video-assisted review. In the editorial…
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Comparison of transannular patch and valve-sparing repair techniques in tetralogy of Fallot
The aim is to evaluate the transannular patch (TAP) repair and valve-sparing repair (VSR) techniques following tetralogy of Fallot (TOF) correction, focusing on post-operative complications and cardiac function. A comprehensive search was performed in PubMed, EMBASE, and Scopus using relevant terms…
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The Editor-in-Chief should be a virtuous friend of the scientific and broader community
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Autonomic dysfunction and resting heart rate abnormalities as early cardiovascular signals in polycystic ovary syndrome (PCOS): a focused review
Polycystic ovary syndrome (PCOS) is a common endocrine–metabolic condition that carries a higher cardiovascular risk than currently reflected by traditional screening tools. Emerging evidence suggests that resting tachycardia and autonomic dysfunction may serve as early, non-invasive indicators of…
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Gerbode defect secondary to tricuspid valve endocarditis: a case report
The Gerbode defect is characterized by a high ventricular septal defect associated with a defect in the septal leaflet of the tricuspid valve, allowing blood to enter the right atrium from the left ventricle. It accounts for approximately 0.08% of intracardiac shunts and may be congenital or…
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Association of insulin and GH/IGF-1 derangements and heart failure: a narrative review
Heart failure (HF) is still one of the most common causes of death today. The vast majority of heart diseases end up leading to HF, which therefore has a high prevalence in the adult population (on average 1–2%), and which increases enormously (over 10%) after the age of 65, becoming the most…
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SGLT2 inhibitors in chronic kidney disease: cardiorenal outcomes, safety, and implementation in primary care
Background: Chronic kidney disease (CKD) is linked to high cardiovascular morbidity and mortality. Many patients remain at risk despite standard treatment. This review assessed the renal, cardiovascular, safety, and primary care implementation outcomes of sodium-glucose cotransporter-2 (SGLT2)…
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Urgent cesarean delivery with contingent ECPR preparation for a parturient with Eisenmenger syndrome and supra-systemic pulmonary hypertension: a case report
Parturients with pulmonary arterial hypertension (PAH) face an increased risk of morbidity and mortality surrounding the peripartum period. Patients with severe PAH and Eisenmenger syndrome have the highest risk for perioperative mortality and provide a significant perioperative challenge for…
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Periodontitis and cardiovascular disease in Africa: a scoping review of local and systemic links, causal plausibility, and research gaps
Background: Cardiovascular disease is the leading cause of mortality globally, with its impact escalating swiftly throughout Africa. Periodontitis, a widespread chronic inflammatory condition, is a recognized correlate of cardiovascular disease in high-income countries; however, evidence from…
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Radiologic sustainability in cardiology: risks, awareness, and clinical implications
Medical radiation exposure in cardiology represents a significant and often underappreciated component of patient risk, with profound implications for individual and population health. Ionizing radiation is a proven carcinogen even at low doses, yet awareness among prescribers and practitioners…
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A systematic review on cardiovascular risk stratification in the artificial intelligence paradigm using radiogenomics
Background: The cardiovascular risk and patient management are evaluated on the basis of risk scores that account for the multifactorial risk factors and thus fail in the estimation of an individual’s cardiovascular disease (CVD) risk. Advances in the field of medical imaging, especially cardiac…
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Mechanical associated disseminated intravascular coagulation during extracorporeal membrane oxygenation: a case series
Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients with refractory cardiac or respiratory failure. Complications associated with ECMO include bleeding, thrombosis, and coagulopathy. Overt disseminated intravascular coagulation (DIC) in ECMO patients is a rare but…
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Multi-class valvular heart disease classification and severity detection with enhanced accuracy using convolutional neural network
Aim: Valvular heart disease (VHD) is an important factor in cardiovascular mortality. While early diagnosis is essential, existing methods often lack accuracy, leading to misdiagnosis. This study explores the use of deep learning (DL) for multi-class classification of VHD using phonocardiograph…
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Gasdermin D: a key mediator of inflammation in cardiovascular disease with a focus on atherosclerosis
Gasdermin D (GSDMD) has been identified as a potential key effector protein within the inflammatory response and is characterized as a primary executor of pyroptosis through the formation of transmembrane pores. This review evaluates the emerging role of GSDMD-mediated pyroptosis in the…