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iMetaOmics
Scopus
ISSN 2996-9514 · Wiley · 181 artikel di indeks
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Artikel Jurnal
Strategies and mechanisms of precision genome engineering: From gene editing to genome writing
Abstract Genomic manipulation has advanced from stochastic nuclease‐mediated disruption toward programmable, deterministic precision. Early clustered regularly interspaced short palindromic repeats (CRISPR) strategies enabled targeted mutagenesis through double‐strand breaks; however, their…
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Artikel Jurnal
Antarctic soil microbiomes encode structurally conserved and phylogenetically diverse beta‐lactamases
Abstract Antimicrobial resistance is a major global health threat shaped not only by clinical settings but also by environmental reservoirs, in line with the One Health framework. Antarctic and Subantarctic soils represent a largely unexplored component of the environmental resistome, particularly…
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Artikel Jurnal
A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry
Abstract The high lethality of the Ebola virus (EBOV) underscores the critical need to understand its molecular lifecycle. Here, we systematically mapped EBOV‐host interactions using affinity purification‐mass spectrometry (AP‐MS) and proximity labeling, generating a comprehensive protein–protein…
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Artikel Jurnal
Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome
Abstract Sjögren's syndrome (SjS) is a systemic autoimmune disorder characterized by lymphocytic infiltration of exocrine glands, leading to dry eyes and mouth. While previous genome‐wide association studies (GWAS) and transcriptomic analyses have identified genes associated with SjS, predictive…
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Artikel Jurnal
Warm‐wet transition restructures arid lake microbiomes and functional potential
Abstract Over the past six decades, northwestern China has undergone a pronounced climatic transition from a “warm‐dry” to a “warm‐wet” regime, driving substantial shifts in lake water level (WL), salinity, and nutrient conditions. However, how this hydroclimatic transition restructures lake…
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Artikel Jurnal
Harnessing microbial metabolism and nutrition to target the gut–mammary axis for better livestock production and health
Abstract The gut‐mammary axis orchestrates bidirectional crosstalk linking intestinal homeostasis and mammary function through integrated neural, endocrine, and immune pathways. Dysregulation driven by gut microbiota dysbiosis or metabolic dysfunction compromises lactation performance and induces…
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Artikel Jurnal
Microbiome‐mediated plant‐soil feedbacks as a tool for resilient agriculture
Abstract Conventional agricultural intensification has eroded the biological foundations of productive soil by disrupting the reciprocal interactions, plant‐soil feedback (PSF), through which plants actively shape and are continuously shaped by the soil microbiome. Although the molecular mechanisms…
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Artikel Jurnal
Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention
Abstract Pancreatic cancer (PC) remains one of the most lethal malignancies worldwide, characterized by dense desmoplastic stroma, profound immunosuppression, and poor responsiveness to conventional therapies. Accumulating evidence positions the intratumoral microbiome, encompassing bacteria as…
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Artikel Jurnal
Artificial intelligence driven diet‐intestinal microbiota‐host health integration: A four‐dimensional paradigm for advancing host wellness research
Abstract The artificial intelligence (AI)‐driven diet‐intestinal microbiota‐host health integration paradigm has emerged as a novel framework for advancing host health research. Intestinal microbiota serves as a key mediator linking dietary signals to host homeostasis, while AI enables efficient…
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Artikel Jurnal
Bile acid metabolism and signaling in human and animal health: A One Health perspective
Abstract The One Health concept emphasizes the interdependence of human, animal, and ecosystem health. Against this broad backdrop, bile acids (BAs), as central products of host‐microbiota co‐metabolism, act far beyond their classical role in lipid emulsification. This review systematically…