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Exploration of Endocrine and Metabolic Diseases
ISSN 2998-2456 · Open Exploration Publishing Inc. · 82 artikel di indeks
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Artikel Jurnal Teks lengkap
Development and validation of a novel risk assessment model for necrotizing fasciitis in patients with diabetic foot
Aim: Necrotizing fasciitis (NF) is a severe and early challenging-to-identify complication of diabetic foot (DF). This study aimed to develop and validate a novel risk assessment model for NF with DF patients utilizing conventional clinical indicators. Methods: A retrospective analysis was…
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Fat deposits and their relationship with type 2 diabetes in patients with metabolic syndrome
Aim: In Mexico, 18.3% of patients over 20 years of age suffer from type 2 diabetes mellitus (T2DM). Visceral fat has been identified as a risk factor for developing T2DM, considering that its effect depends mainly on the amount, it has been proposed that its location also participates in the…
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Innovative regenerative genetic and nano therapies for diabetes and metabolic disease
Diabetes and metabolic dysfunction represent growing global health challenges, and current therapies mitigate hyperglycemia without sufficiently altering the underlying disease processes. Rapid advances in regenerative medicine, gene editing, and nano-enabled drug delivery are reshaping therapeutic…
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A novel therapeutic strategy of obesity from the perspective of SPMs
The global prevalence of obesity and type 2 diabetes mellitus (T2DM)—the most common metabolic disorders—has reached epidemic proportions over the past half-century, with obesity being a key driver of insulin resistance and T2DM development. These disorders are characterized by metaflammation…
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Treating obesity with GLP-1 RAs: does sex matter? A commentary on the meta-analysis by Yang et al. (J Diabetes 2025;17(3):e70063)
This commentary discusses a recent article (J Diabetes 2025;17(3):e70063), focusing on interpreting the study’s sex-stratified results in a broader clinical and mechanistic context. The authors of this systematic review and meta-analysis of 14 randomized trials demonstrate that women achieve…
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Impaired cytokines in diabetes and diabetic foot ulcers: mechanisms and prospects
A pro-inflammatory state with elevated cytokines influenced by both environmental and genetic factors is a key characteristic of both type 1 diabetes (T1DM) and type 2 diabetes (T2DM). Cytokines promote immune cell infiltration and degradation of the pancreatic islets, which play a direct role in…
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Cardiovascular effects of endocrine hypertension: insights from primary aldosteronism, pheochromocytoma, and Cushing syndrome
Endocrine hypertension (HT) includes a group of secondary hypertensive disorders caused by hormonal excess, primarily primary aldosteronism (PA), pheochromocytoma and paraganglioma (PPGL), and Cushing syndrome (CS). Although relatively uncommon, these conditions confer a disproportionately high…
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Association between APOA1 gene (rs670) single-nucleotide polymorphism and dyslipidaemia: a systematic review and meta-analysis
Background: Metabolic syndrome and dyslipidaemia increase the risk of death by two or three times. In this context, the role of apolipoprotein A-I (Apo A-I), the main structural protein of high-density lipoprotein (HDL), stands out, since its anti-inflammatory potential reduces cardiovascular risk…
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Osteoporosis: definition, diagnosis, and considerations prior to starting treatment
Osteoporosis is a disabling disease with a significant impact on the global population, particularly among older men and postmenopausal women. Several factors contribute to the increasing prevalence of osteoporosis, including greater life expectancy and the absence of symptoms in its early stages…
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New avenues in metabolic disease treatment: duodenal mucosal resurfacing and gene therapy
Metabolic diseases including obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction-associated steatotic liver disease (MASLD) are increasing rapidly worldwide and contribute substantially to morbidity, mortality, and healthcare costs. Current therapies, including glucagon-like…
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Antioxidant and anti-inflammatory functional foods for the management of type 2 diabetes: a systematic review
Background: Diabetes mellitus (DM) refers to a group of metabolic diseases characterized by reduced insulin synthesis and release, leading to hyperglycemia, oxidative stress, and inflammation. The prevalence of DM continues to increase worldwide, primarily driven by type 2 DM (T2DM). While numerous…
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Expert Consensus on Type 2 Diabetes Remission
Establishing remission as a clinical goal for carefully selected patients with Type 2 Diabetes Mellitus (T2DM) represents a fundamental shift from the traditional paradigm of lifelong disease management. Short disease duration, preserved C-peptide levels, and overweight or obesity are the central…
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Glucagon-like peptide 1 receptor agonists in cardiovascular-kidney-metabolic syndrome: a review
With the rising global prevalence of obesity and type 2 diabetes, metabolic disorders have become major drivers of cardiovascular morbidity and mortality worldwide. Cardiovascular-kidney-metabolic (CKM) syndrome encompasses obesity, type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD), and…
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Behavioral and biochemical evaluation of the neuroprotective role of naringin in streptozotocin‑induced diabetic peripheral neuropathy in rats
Aim: Diabetic neuropathy is the most prevalent diabetic complication, impacting up to 60% of people with diabetes. It is characterized by distal symmetrical loss of sensory function in the lower extremities, presenting with spontaneous excruciating neuropathic pain, hyperalgesia, and allodynia that…
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Sustained reductions in hyperglycemia using a diabetes app with connected glucose meters in people with type 2 diabetes at higher risk for complications
Aim: Assess the benefits of using a diabetes app and connected blood glucose (BG) meter in people with type 2 diabetes (PwT2D) with higher-than-recommended mean BG. It is well understood that sustained higher levels of glycemia are linked to diabetes related complications and that early…
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The relationship between triglyceride-glucose index and lipid profile, hormonal, and biochemical parameters in patients with polycystic ovary syndrome
Aim: The aim of this study was to investigate the relationship between the triglyceride-glucose (TyG) index and hormonal, biochemical, and lipid parameters in patients with polycystic ovary syndrome (PCOS). Methods: In this retrospective single-center study, 2,243 outpatient records were reviewed…
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The impact of patient-centred care on adherence, psychosocial and clinical outcomes in the management of type 2 diabetes: a systematic review
Background: Type 2 diabetes (T2D) is a chronic metabolic condition requiring sustained pharmacological and behavioural management. Suboptimal medication adherence remains a major barrier to achieving adequate glycaemic control and is associated with increased morbidity, mortality, and healthcare…
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Estrogen improves islet morphology and gut hormone distribution to enhance glucose control in ob/ob mice
Aim: Estrogens regulate energy balance and glucose homeostasis, but whether they coordinate endocrine changes across the gut–pancreas axis in obesity remains unclear. This study examined whether ethinyl estradiol (EE2) improves metabolic control in obese diabetic mice through combined effects on…
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Low adiponectin levels and ADIPOQ +276G>T single nucleotide polymorphism are associated with type 2 diabetes mellitus in the Sudanese population: case-control study
Aim: Type 2 diabetes mellitus is a polygenic disorder influenced by multiple genes and environmental factors. Polymorphisms in the adiponectin gene are linked to insulin resistance, serum adiponectin levels, and type 2 diabetes mellitus. This study investigated the association between adiponectin…
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Artikel Jurnal Teks lengkap
The role of the resveratrol-sirtuin axis in the treatment of metabolic dysfunction-associated diseases
Obesity, diabetes mellitus (DM), metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular diseases (CVDs) share pathogenic mechanisms like oxidative stress and inflammation. Resveratrol (RSV) offers therapeutic potential by activating the sirtuin (SIRT) signaling…