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Med Research
ISSN 2998-4971 · Wiley · 72 artikel di indeks
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Artikel Jurnal
Omics GWAS: A Multi‐Omics Integrative Analysis Platform for Genome‐Wide Association Studies
ABSTRACT With the rapid advancement of genome‐wide association studies (GWAS), downstream analyses of GWAS data have become essential for elucidating the genetic mechanisms that underlie complex diseases. However, current post‐GWAS analyses face numerous challenges, including heterogeneous data…
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Artikel Jurnal
Transforming Musculoskeletal Disorder Management With Multimodal AI Platform for Early Diagnosis, Self‐Screening, and Personalized Care
ABSTRACT Musculoskeletal disorders such as osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OP) affect millions worldwide, often progressing silently until advanced stages. Accessible early risk stratification remains challenging because conventional diagnosis often depends on…
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Artikel Jurnal
Development and Validation of a Questionnaire‐Based Model for Households With Multiple Helicobacter pylori Infections: A Family‐Based Screening Strategy
ABSTRACT Helicobacter pylori (H. pylori) infections are known to cluster within households. To improve the efficiency of population‐wide H. pylori screening, we therefore developed and validated a questionnaire‐based model to identify households with multiple infections. This model was developed in…
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Mapping Causal Biology: Mendelian Randomization in the Era of Big Data
ABSTRACT Mendelian randomization (MR) is a method that utilizes genetic variants as instrumental variables to determine causal relationships between exposures and outcomes, thereby mitigating confounding bias and reverse causality inherent in observational studies. Rooted in Mendel's laws of…
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KMT5C‐Mediated H4K20me3 Recruits EWSR1 to Propel Clear Cell Renal Cell Carcinoma Progression via Regulating ACADM Transcription and m6A Modification
ABSTRACT Clear cell renal cell carcinoma (ccRCC) exhibits notable genetic and epigenetic heterogeneity. Although H4K20me3 is markedly enriched in ccRCC samples, the precise functional role of this histone modification in ccRCC pathogenesis remains elusive. The expression and prognostic value of…
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Artikel Jurnal
easyGBDR: An Integrated R Toolkit for Comprehensive Secondary Analysis of Global Burden of Disease Database
ABSTRACT The Global Burden of Disease (GBD) database provides essential primary data for public health research. However, its complexity and diversity pose challenges for conducting advanced secondary analyses. To address these challenges, we developed easyGBDR, an innovative integrated R toolkit…
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Artikel Jurnal
Single‐Cell Transcriptomics and Deep Learning Link N‐(2‐Furoyl) Glycine to GLRX3 in Gastric Cancer
ABSTRACT Gastric cancer remains a health burden, and its metabolic drivers are poorly defined. N‐(2‐furoyl) glycine, a circulating metabolite, has been implicated in tumor biology. We investigated its causal role in gastric cancer and the underlying mechanism. Mendelian randomization using FinnGen…
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Prioritizing Modifiable Risk Factors for Cardiovascular Diseases in Adults With Hypertension: A Prospective Cohort Study
ABSTRACT The relative importance and biological mechanisms of modifiable risk factors for cardiovascular diseases remain unclear among adults with hypertension. In a large prospective cohort of 134,417 adults with hypertension, we evaluated the individual and joint effects of modifiable risk…
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Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies
ABSTRACT Osteoarthritis (OA) is a common joint disease characterized by degenerative lesions of articular cartilage, subchondral osteosclerosis, osteophyte formation, and synovial inflammation. The traditional view is that OA is a degenerative disease, mainly related to mechanical damage to…
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Artikel Jurnal
Proteomic Signatures of Ectopic Fat Distribution: Tissue‐Specific Drivers and Clinical Implications
ABSTRACT Ectopic fat deposition is a major risk factor for cardiometabolic diseases, but its systemic molecular drivers and disease associations remain poorly understood, owing to the reliance on correlation studies, a single‐organ perspective, and limited disease coverage. Plasma proteomic data…
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White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation
ABSTRACT White adipose tissue browning, by activating core molecules such as PRDM16 and UCP1 to regulate energy metabolism, exhibits a double‐edged sword effect in metabolic diseases and tumors, making it a current research hotspot. This paper systematically reviews its biological characteristics…
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GAnnoViz: A Cloud‐Integrated Platform for Chromosome‐Level Feature Annotation and Visualization in Biomedical Multi‐Omics
ABSTRACT With multi‐omics approaches increasingly employed to investigate multidimensional biological systems, current workflows often lack sufficient integration with the underlying genome, limiting comprehensive understanding of genomic structure and chromosomal preferences of candidate genes…
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Artikel Jurnal
Alveolar Fibroblasts Respond to Pseudomonas Aeruginosa Infection With Cytokine Secretion: Role in Acute Lung Inflammation
ABSTRACT Alveolar fibroblasts play a key role in regulation of lung inflammation. Pseudomonas aeruginosa (PAO) is one of the most common pathogens causing lung injury, and the role of PAO‐infected alveolar fibroblasts in such a condition remains unclear. The tumor necrosis factor (TNF)‐α was…
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Artikel Jurnal
Deep Learning Unlocks Behavioral Prediction and Neurobehavioral Decoding
ABSTRACT Forecasting behavior and uncovering its underlying neuronal mechanisms are two pivotal pillars in understanding biological behaviors. The former focuses on predicting future actions and patterns through observational data, whereas the latter delves into the neural circuits and computations…
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A Data‐Driven Redefinition of Early Relapse in Pediatric T Cell Acute Lymphoblastic Leukemia: Evidence for Progression of Disease 15 Months
ABSTRACT Early relapse represents the most adverse prognostic event in pediatric T cell acute lymphoblastic leukemia (T‐ALL). Clinically, early relapse of pediatric T‐ALL is generally defined as relapse occurring within the first 18 months post‐diagnosis, yet its temporal definition has largely…
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Artikel Jurnal
Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends
ABSTRACT The escalating global burden of diabetes has led to a rise in diabetic peripheral neuropathy (DPN) that is characterized by significant heterogeneity, with its various subtypes exhibiting distinct yet overlapping clinical manifestations and pathogenic drivers. This complexity obscures a…
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Comprehensive Evidence for Mortality and Underlying Morbidity Related to Visceral Fat Distribution
ABSTRACT Linking obesity to mortality is an intriguing and controversial topic. This study tried to comprehensively assess 8 adiposity surrogates and mortality association among middle‐to‐old‐aged adults to identify a superior one, and explore explanatory disorders. Data sources included the…
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Artikel Jurnal
Molecular Diagnostics in Thyroid Nodules: Current Applications, Clinical Value, and Future Perspective
ABSTRACT Molecular diagnostics have become an important adjunct to ultrasonography and fine‐needle aspiration (FNA) for thyroid nodules, especially in Bethesda III/IV cytology where malignancy risk is uncertain. This narrative review summarizes the diagnostic and prognostic value of key genomic…