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Biobacta Journal of Biochemistry and Molecular Biology
ISSN 3009-741X · Society of Pathological Biochemistry and Hematology (SPBH) · 45 artikel di indeks
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Protective effects of Vitamin E against Zinc Oxide nanoparticle--induced Oxidative stress, genotoxicity, and histotoxicity of hepatic and testicular tissues in male albino rats
Nano zinc oxide has the potential to be harmful, so it is important to assess its effects on human health and the biological system. In the current study, vitamin E (100 mg/kg) was used to explore its antioxidant role in mitigating the potential toxicity of ZnO NPs (50 and 200 mg/kg) in male albino…
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Oxidative Stress and Malignancy: The Central Role of Reactive Oxygen Species (ROS) in Cancer
Reactive oxygen species (ROS) are unavoidable byproducts of aerobic metabolism that play a dual and paradoxical role in cancer biology. At physiological levels, ROS function as essential second messengers regulating proliferation, differentiation, and survival signaling. However, excessive ROS…
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Immunological and Bioinformatics Meta-Analysis Linking the TLR4-rs4986790 SNP and Bacterial Infections in Patients with Cystitis and Polynephritis
Toll-like receptor genes, especially TLR-4, produce transmembrane receptors that, depending on their expression, induce a pro- or anti-inflammatory response. TLRs are the first line of the body's defense against pathogens, including infectious ones. The most prevalent kind of mutation occurs in the…
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Chemical pesticides: Their negative effects on the environment and ways to reduce them
We live in a globalized world in which the production, trade, and consumption of agricultural crops and other goods and services that use pesticides and fertilizers are shaped in large quantities by the needs and demands of a growing population and megatrends (such as urbanization and a growing…
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Salivary Chemerin as an Inflammatory Biomarker Associated with Dental Caries Susceptibility in Patients with Type 2 Diabetes Mellitus
Background: Type 2 Diabetes Mellitus (T2DM) has a significant association with oral health problems such as dental caries. Chemerin is an adipokine involved in metabolic and inflammatory conditions. Aim of the study: This study aims to explore the possible significance of salivary chemerin as an…
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Biological effect of radiation on human Interleukin-12 in Babylon governorate, Iraq
The nuclear radiation caused by radionuclides and from the sources of activity has become a major part of life, as it is a part of our health, food, and has several applications in several fields, including biology, medicine, agricultural fields, industrial field and in a nuclear power station…
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The relationship between Staphylococcus and wound infection
Gram-positive, catalase-positive cocci from the genus Staphylococcus in the family Staphylococcaceae are known as Staphylococcus aureus. Regardless of the patient's age, location, or environment, Staphylococcus aureus is the most prevalent bacterium causing skin infections globally. A few toxins…
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The Impact of Iron and Vitamin D Deficiency on Cognitive Function and Concentration Among University Students
Iron and vitamin D are vital nutrients necessary for a multitude of physiological processes throughout an individual's lifespan. Iron plays a crucial role in the typical development and operation of the nervous system, the regeneration of red blood cells, and the transport of oxygen. Deficiency in…
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Physiological Burden of Cardiometabolic and Respiratory Comorbidities in Patients with SARI-Related Symptoms: A Cross-Sectional Analysis of Diabetes Mellitus, Documented Heart Failure, Bronchial Asthma, Age, Sex, and Symptom Phenotypes
Background: The physiological state can modify disease expression and burden for many respiratory syndromes. Severe acute respiratory infection (SARI) is one of these syndromes. The presence of chronic respiratory and cardiometabolic conditions can alter the immune response and increase the host's…
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Evaluation of Th17 Cells, CD4+ T Cells, IL-17 and IL-22 in Streptococcus Pyogenes-Associated Psoriasis: An Integrated Immunological Study
Background: Psoriasis affects 2 to 3% of adults worldwide. Once primarily associated with older age and the male sex, emerging data indicate a U-shaped psoriasis prevalence curve. Th17 cells produce IL-17 and IL-22, which drive keratinocyte activation and inflammation, respectively. Objective: The…
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Dose-Dependent Influence of Vitamin D₃ on Blood Cell Indices and Clotting Function in Rats with Phenylhydrazine-Induced Haemolytic Anaemia
Background. Coagulation disturbances often coexist with anaemia but are rarely studied together. Vitamin D receptors on megakaryocytes and erythroid precursors suggest this hormone may influence both erythropoiesis and haemostasis simultaneously. Aim. To determine whether oral vitamin D₃ restores…
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Gold Nanoparticles Cytotoxicity against Esophageal Carcinoma Cells: An In Vitro Study Using Glutathione-Modified Nanoparticles
Background: Esophageal carcinoma remains an aggressive malignancy with poor prognosis and limited treatment options. Nanotechnology has introduced opportunities in cancer therapy, using gold nanoparticles (GNPs) due to their biocompatibility and tunable properties. Objective: This study evaluates…
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Flower-like nano- to micro-structured 3D functional materials: From conception to fabrication, application, and prospection
Nanoflowers are an emerging class of flower-shaped nanoparticles that have attracted significant research interest because of their simple synthesis, excellent stability, and enhanced performance across a wide range of applications. This critical review provides a comprehensive overview of the…
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Evaluation of the Larvicidal Activity of Bacillus thuringiensis Compared with Chemical Insecticides Against the forth instar Larvae of the Culex Mosquito
The aim of the study at the possibility of finding an integrated control program, consisting of the biological preparation made from the biocontrol (Bacillus thuringiensis) in combination with chemical pesticides (gentapride, metkol, methoprene) used to control Culex. Each of the biological…
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Electrolytic Synthesis of magnesium oxide nanoparticles (MgO NPs) for Dye- Sensitized Solar Cells Applications
The present work reports a simple and comprehensive electrochemical approach for the production of magnesium oxide nanoparticles (MgO NPs) from magnesium chloride (MgCl2) solution under alkaline conditions and subsequent calcination at regulated temperatures. The mean crystalline particle size was…
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Impact of Environmental and Lifestyle Factors on Human Blood Physiology: Exercise, Altitude, Climate Change, and Sugar Substitutes
The human blood physiology is an active system that is closely connected with environmental and lifestyle changes, which affect such processes as erythropoiesis, coagulation, platelet activity, nitric oxide (NO) signaling system, and oxygen transport. It is a synthesis of evidence based on recent…
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Molecular Docking and Pharmacokinetic Profiling of Dimethyl ellagic acid from Eucalyptus globulus as a Broad-Spectrum Inhibitor of Microbial and Insecticidal Virulence Toxins
Background: Antimicrobial resistance and toxin-mediated virulence are significant health issues of concern worldwide. Aim: This study set out to computationally refurbish Dimethyl ellagic acid as a pan-specific toxin protein inhibitor of bacteria, insects, arachnids, and marine organisms by…
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Bacterial Pathogens in Wound and Burn Infections: A Comprehensive Review
Wound and burn injuries are a massive burden on healthcare in the world, and infection is the most common and severe complication that results in the delay of the healing process, sepsis, multi-organ failure, and death. The healing process is disturbed by the colonization and further infection of…
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Hematological Profiling and Biochemical Parameters Analysis in Female Breast Cancer
Breast cancer is the most common cancer affecting women worldwide. It occurs when abnormal cells in the breast grow uncontrollably and form a tumor. Thirty-two serum specimens were taken from women and were divided into two groups: 15 samples from women with breast cancer and 17 from healthy women…
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Impacts of some plant extracts and how effectively they work against Pseudomonas aeruginosa: Review article
One way that pathogens develop resistance to pharmaceuticals is by forming biofilms, which are 3-D communities of bacteria. As a result, there is considerable interest in identifying new antibiofilm agents from nature that can be used to treat these infections. This review looked at a very common…