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Bulletin of Pharmaceutical Sciences. Assiut University (2026)
ISSN 3009-7703 · Assiut University, Faculty of Pharmacy · 1.456 artikel di indeks
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Pharmacognostic characterization and GC–MS profiling of the leaf lipid fraction of Roystonea regia (kunth) O.F. Cook. Family Arecaceae cultivated in Egypt.
Roystonea regia (Kunth) O.F. Cook (Arecaceae) is an ornamental palm cultivated in both tropical and near-tropical regions and has been considered a potential source of bioactive lipids. The present study investigates the leaves of R. regia cultivated in Assiut, Upper Egypt, through combined…
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Fatty acids and derivatives from Chlorella vulgaris extracts as Antibacterial, antibiofilm, and Antioxidant agents
The lipid-rich extract of Chlorella vulgaris has shown potential biological activities, such as antibacterial, antibiofilm, and antioxidative properties. For this study, a species of microalgae, Chlorella vulgaris, was isolated from the surrounding aquatic environment. The lipids of this alga were…
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Buccal Films for the Treatment of Oral Candidiasis: Recent Advances and Future Perspectives
Oral candidiasis remains a common opportunistic fungal infection in which successful treatment depends on maintaining effective antifungal concentrations at the site of infection. Conventional topical dosage forms are frequently limited by rapid salivary clearance and short mucosal residence time…
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Fenticonazole nitrate-loaded spanlastics: An intriguing approach to mediate topical application
Spanlastics are novel elastic carriers made of spans and edge activators. The current study aims to leverage their unique permeation-enhancing properties to improve skin delivery of fenticonazole nitrate (FTN) for the management of fungal infections. FTN spanlastics were fabricated by the ethanol…
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SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL EVALUATION OF ZINC-PHOSPHINE COMPLEXES DERIVED FROM 5-AMINOURACIL AS POTENT ANTIBACTERIAL AND ANTICANCER AGENTS
Abstract: This study focused on the synthesis, spectroscopic characterization, and biological evaluation of a series of zinc-phosphine complexes derived from 5-aminouracil, with an emphasis on their chemical and biological properties. The primary ligand (A1) was synthesized and subsequently…
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Histological and biochemical evidence of the protective effects of artemisinin and thymoquinone against diabetic nephropathy in male rats
Type 2 diabetes mellitus (T2-DM) is a chronic metabolic condition marked by sustained hyperglycemia, leading to systemic consequences such as diabetic nephropathy and haematological disorders. Natural products, particularly bioactive materials, have gained considerable interest as potential…
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Evaluation of the cytotoxicity impacts for a mixture of mushroom, propolis, and vitamin C nanoparticles in cancer cell lines
This study presents the eco-friendly fabrication, through physicochemical analysis, and DNA damage assessment of an innovative multi-element Ag-Se bimetallic nanostructure prepared by means of a single-vessel synthesis with a mixed water-ethanol extract of Ganoderma lucidum , propolis , and vitamin…
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Hormonal, Antioxidant, Anti-inflammatory and Histopathological Effects of Cinnamon Nano-Particles in Infertility-Modeled Female Albino Rats
Bisphenol A (BPA), a common industrial chemical, impairs ovarian function and induces infertility through structural, hormonal, and molecular alterations. In this study, adult female Wistar rats were used to test the protective effects of silver nanoparticles (CNPs) derived from cinnamon against…
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Integrative In Silico and In Vitro Evaluation of Tucatinib as a Potent Inhibitor of TTK Kinase and Cancer Cell Migration
Human TTK (Mps1) kinase is a pivotal regulator of the spindle assembly checkpoint and a high-priority target for antineoplastic interventions. This study employed an integrative pipeline—combining in silico molecular modeling with in vitro biological validation—to evaluate the inhibitory potential…
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PCR-BASED MOLECULAR DETECTION OF LEGIONELLA PNEUMOPHILA IN RESPIRATORY SPECIMENS AT ASSIUT UNIVERSITY HOSPITALS
This study sought to ascertain the prevalence of Legionella pneumophila as a causal agent of atypical pneumonia and to assess the effectiveness of a polymerase chain reaction (PCR) assay for its detection in respiratory specimens. Sputum and bronchoalveolar lavage samples were obtained from…
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Diagnostic Role of GDF-15 and ARFIP2 as Biomarkers for the Progression of Diabetic Nephropathy and Their Correlation with Glomerular Filtration Rate (GFR)
Diabetic nephropathy (DN) is regarded as one of the most serious complications of diabetes mellitus. It is mainly characterized by a progressive increase in urinary albumin excretion, and it may also be accompanied by structural damage to the glomeruli or a decline in the glomerular filtration rate…
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Synthesis, Characterization, Biological Evaluation, and Molecular Docking of Novel Heterocyclic Compounds Derived from 4,4'-Azo Dianiline
This study included the use of 4,4′-azoaniline as a nucleus in the preparation of Schiff bases, which are considered the basis for the preparation of heterocyclic rings. When reacted with sodium azide, a five-membered ring derived from tetrazole is produced. When reacted with anthranilic acid, a…
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Hepatoprotective Effect of Broccoli Sprout Extract and Its Synergistic Role in Enhancing Adriamycin Efficacy for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a major cause of cancer death and caused by environmental toxins. Adriamycin (ADR), a chemotherapeutic agent, is the backbone of HCC treatment, but its clinical efficacy is limited by its high toxicity, raising the possibility of natural chemosensitizers with…
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Involvement of p38 MAPK in the neuroprotective and hepatoprotective effects of montelukast in thioacetamide-induced hepatic encephalopathy in rats
Background: Montelukast (MTK), a CysLT1R antagonist commonly used in asthma, has neuroprotective effects in several neuronal disorders. The study goal is to investigate the hepato- and neuroprotective effects of MTK in hepatic encephalopathy (HE) rat model induced by thioacetamide (TAA) relative to…
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Innovative Ten-Minutes Time-Programmed Chromatographic Stability Study for Fenbendazole and Rafoxanide Anthelmintic binary mixture; Add-on “Oxfendazole” Screening Simultaneously
Benzimidazole anthelmintic derivative, Fenbendazole, is formulated in equal concentration with salicylanilide one, Rafoxanide, “Curafluke® suspension”, for broad antiparasitic activity in livestock animals. Herein, the first stability-indicating chromatographic assay method to evaluate this binary…
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Combined in vitro and in silico analysis of acyclovir and valacyclovir against Foot-and-Mouth Disease Virus Serotype SAT2
Foot-and-Mouth Disease (FMD) is a highly contagious viral disease of livestock, caused by Foot-and-Mouth Disease Virus (FMDV), having significant economic and animal health impacts across the world. Although vaccination remains the primary control strategy, its limitations, including short-lived…
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IN VITRO AND IN VIVO PERFORMANCE OF LORNOXICAM SUPPOSITORY FOR PAIN MANAGEMENT USING MODIFIED TAMARIND GUM POLYSACCHARIDE
This study presents a novel mucoadhesive in situ gelling liquid suppository of lornoxicam, specifically leveraging modified tamarind gum polysaccharides to overcome limitations associated with conventional rectal drug delivery. Liquid suppositories were prepared using Poloxamer 407 and mucoadhesive…
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Beyond Gels and Rinses: Spray-Based Platforms for Oral Ulcer Therapy
Oral ulcers are common, painful lesions that significantly affect quality of life. Conventional formulations, including gels, pastes, and mouthwashes, often suffer from poor retention, limited site-specific delivery, and frequent dosing. Spray-based drug delivery systems have emerged as promising…
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Impact of methamphetamine and other abused drugs on bioclinical parameters
The physiological and biochemical alterations caused by drug abuse are complex and affect many organ systems as renal and vascular system. The aim to explore the relationship between the effect of abused methamphetamine and other drugs with kidney function and vascular system. A case-control study…
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Computational Exploration of Celery (Apium graveolens) Leaf Compounds as Potential Anti-Hypertensive candidate
Hypertension has significantly increased on a global scale and is considered a leading cause of cardiovascular disease. Previous studies have demonstrated that celery possesses strong potential as an antihypertensive agent. This study aims to identify bioactive compounds in celery (Apium…
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