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Journal of Dementia and Alzheimer's Disease
ISSN 3042-4518 · MDPI AG · 60 articles in the index
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Neuropsychiatric Symptoms in Major Neurocognitive Disorder: Associations with Caregiver Burden and Sleep Quality
Background: Neuropsychiatric symptoms (NPSs) are among the most clinically disruptive manifestations of major neurocognitive disorder (MND) and major contributors to caregiver distress. However, the differential contribution of specific neuropsychiatric domains to caregiver burden and sleep quality…
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MicroRNAs as Diagnostic Biomarkers for Alzheimer’s Disease and Related Dementias
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of late-life dementia. As pathology spreads through the brain, affected individuals experience devastating cognitive decline, linguistic impairments, mood changes, and behavioral issues. Developing effective…
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Exploring the Effects of Swimming Exercise on Anxiety-like, Cognitive, and Noncognitive Behaviors Using the rTg4510 Tau Mouse Model
Background/Objectives: Alzheimer’s disease is a neurodegenerative disorder characterized by the accumulation of both amyloid and tau pathology. Lifestyle factors, including exercise, have been shown to be protective against dementia and warrant continued exploration. This study used the rTg4510…
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Apathy as a Potential Mediator of the Association Between Poor Glycemic Status and Incident Cognitive Impairment and Self-Reported Alzheimer’s Disease and Related Dementias in Older Adults: The Health and Retirement Study
Background: Apathy is an increasingly recognized predictor of cognitive decline. Although both poor glycemic status and apathy have been independently linked to cognitive decline, whether apathy mediates the relationship between poor glycemic status and cognitive decline remains unclear. Methods…
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A Systematic Review on the Effects of Speech and Language Therapy in Patients with Dementia
Background/Objectives: Dementia is a progressive neurocognitive disorder characterized by decline in cognitive, communicative, and functional abilities. Speech and language therapists (SLTs) play a role in managing communication and cognitive–linguistic impairments while supporting families and…
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Burden and Risk Factors of All-Cause Dementia in South Asia: An Analysis of Global Health Data and a Framework for Future Dementia Longitudinal Studies in Low-Resource Settings
Background: Dysregulated brain aging leads to dementia in some older adults. South Asia is one of the most populous regions of the world with a rapidly growing older adult population. Yet, very few studies have focused on quantifying the status and risk factors driving aging-related conditions such…
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Art-Based Mindfulness (MindArt) Versus Social Engagement for Stress Reduction in People Living with Dementia and Care Partners: A Single-Blinded Randomised Crossover Trial
Background/Objectives: Mindfulness-based interventions show promise for reducing stress in people living with dementia, but rigorous evidence against active control conditions remains limited, and little is known about how to adapt mindfulness for the specific needs of this population. MindArt is…
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Fluid and Imaging Biomarkers in Lecanemab Therapy for Early Alzheimer’s Disease: Current Evidence, ARIA Risk Prediction, and Treatment Monitoring
Background/Objectives: Lecanemab, a humanized anti-amyloid-β protofibril antibody, achieves substantial amyloid clearance and modest slowing of clinical decline in early Alzheimer’s disease (AD). Amyloid-related imaging abnormalities (ARIA) represent the most clinically important safety concern…
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B Sharp: An Investigation into the Effects of Single Symphony Performance Experiences on Cognition in Individuals with Alzheimer’s Disease and Related Dementias
Background/Objectives: Current trends show a significant increase in Alzheimer’s disease and related dementias (ADRD) rates, reflecting a growing need for interventions. Recently, non-pharmacological interventions have received increased recognition as a viable option for ADRD prevention and…
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Understanding Public Discourse on Alzheimer’s Disease and Dementia: A Sentiment Analysis and Topic Modeling Study of Social Media Data
Background: Alzheimer’s disease (AD) and dementia are growing global health challenges, yet public understanding of these conditions remains poorly characterized. Methods: This study analyzed 17,578 English-language tweets from Twitter/X collected throughout 2024 to characterize public discourse…
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We Are All in the Same Boat: Effects of a Five-Day, Multidimensional Intervention on Healthy and Alzheimer’s-Affected Older Adults Aboard the Nave Italia
Background/Objectives: This study evaluated the effects of a five-day intensive intervention aboard the Italian Navy sailing vessel Nave Italia for both cognitively healthy older adults and individuals with Alzheimer’s disease, focusing on autonomy, depressive symptoms, quality of life, and…
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Impact of Dementia on Outcomes in Patients Hospitalized with Urinary Tract Infections
Background: People living with dementia (PLWD) are at increased risk for medical complications, including urinary tract infections (UTIs), which are often presented atypically with delirium or behavioral changes. These atypical presentations frequently prompt psychiatric consultation and…
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Functional and Structural Connectivity in a Non-Transgenic Model of Alzheimer’s Disease
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive decline, reflecting widespread brain dysfunction across multiple neural systems. Early detection of pathological changes is critical for enabling timely intervention, improved…
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Environmental Pollutants and Neuroinflammation in Alzheimer’s Disease Progression
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder traditionally characterized by the extracellular accumulation of amyloid-beta (Abeta) plaques and the formation of intracellular neurofibrillary tau tangles; however, the prevailing scientific paradigm has shifted toward an…
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Neuroimaging Alzheimer’s Disease Through a Sex-Specific Lens: Implications for Women’s Brain Health
Background/Objectives: Alzheimer’s disease (AD) disproportionately affects women, who account for nearly two-thirds of affected individuals worldwide. This sex imbalance cannot be explained by longevity alone and likely reflects complex interactions among biological sex, endocrine aging, genetic…
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Dynamic Coupling Association of Care Partner Quality of Life and Cognitive and Depressive Symptoms Experienced by Persons Living with Dementia
Background/Objectives: Persons living with dementia (PLwD) receive informal care services from loved ones, commonly referred to as care partners (CPs). While the symptoms (e.g., depressive affect, cognitive impairment) experienced by PLwD are recognized to influence CP wellbeing, longitudinal…
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Meaning, Purpose, and Post-Diagnostic Adjustment in Early-Stage Dementia: A Positive Psychology Perspective
Dementia affects approximately 55 million people worldwide, yet the psychological experience of diagnosis and the determinants of post-diagnostic well-being remain underexplored relative to biomedical research priorities. The existing literature has been predominantly deficit-oriented, focusing on…
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Counterfactual, Longitudinal, and Multimodal Explainable AI for MRI-Based Alzheimer’s Diagnosis: A Structured Review
Background/Objectives: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder for which MRI-based AI systems are increasingly used for diagnosis and prognosis. However, many published approaches remain misaligned with the requirements of trustworthy clinical use. Predicted risks are…
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State-of-the-Art Testamentary Capacity Assessment Tool (TCAT) in Dementia: A Review of Studies and Update Report
Background: The Testamentary Capacity Assessment Tool (ΤCAT) is a brief instrument with good psychometric properties, specifically designed for the assessment of testamentary capacity (TC) in individuals with dementia. It assesses memory, perception of financial matters, and judgment, as well as…
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Low Brain Levels of Dietary Polyphenols and Their Conjugates: Reassessing Mechanisms of Alzheimer’s Disease Prevention
Dietary polyphenols such as quercetin, resveratrol, and (−)-epigallocatechin-3-gallate (EGCG) have shown neuroprotective effects in epidemiologic and experimental studies of Alzheimer’s disease (AD), although clinical evidence remains limited. This review highlights the importance of investigating…