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LabMed Discovery
Scopus
ISSN 3050-4740 · Elsevier · 59 articles in the index
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Journal Article
Utility of liquid biopsy for EGFR mutation testing in lung adenocarcinoma in a resource-limited setting
Objectives: EGFR mutation testing is key for the management of lung adenocarcinoma. Here, we aimed to examine the contribution of liquid biopsy versus tissue biopsy and formalin-fixed paraffin-embedded (FFPE) tissue to EGFR mutation testing in lung adenocarcinoma in a resource-limited setting…
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Journal Article
Plasma-guided mitotane for the treatment of adrenocortical carcinoma: adjuvant care to advanced disease
Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine malignancy with limited therapeutic options and a substantial risk of postoperative recurrence. Mitotane remains the only US Food and Drug Administration (USFDA) and the European Medicines Agency (EMA) approved agent…
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Journal Article
Analytical and clinical evaluation of ABEI-based CA125 immunoassays in heart failure: method comparison, biomarker profiles and prognostic insights
Objective: Carbohydrate antigen 125 (CA125), which is traditionally used in ovarian cancer diagnostics, is increasingly recognized as a marker of congestion and inflammation in heart failure (HF). This study compared the analytical performance of N-(4-aminobutyl)-N-ethylisoluminol (ABEI)-based…
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Journal Article
Current status and future prospects of external quality assessment (EQA) in the Republic of Korea
External quality assessment (EQA) is a cornerstone of laboratory quality management, ensuring the accuracy, comparability, and reliability of test results across institutions. In the Republic of Korea, the Korean Association of External Quality Assessment Service (KAEQAS) has played a leading role…
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Journal Article
Toward objective diagnostics in depression: Blood metabolomic analysis focusing on depressive states, suicidal ideation, and personality traits
Depression is a heterogeneous mental illness with substantial personal and societal burdens, yet its diagnosis still relies heavily on subjective assessments. Recent advances in blood-based metabolomics have opened new avenues for identifying objective biomarkers associated with depressive…
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Journal Article
Mendelian randomization analysis of free cholesterol in VLDL subfractions and the risk of colorectal cancer
Objective: This study analysed the causal relationships between free cholesterol-to-total lipid ratios in different very low-density lipoprotein (VLDL) subfractions and the risk of colorectal cancer (CRC) via a two-sample Mendelian randomization (MR) approach. Methods: Genetic variants associated…
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Journal Article
USP32 facilitates tumor development and is correlated with poor clinical outcomes in hepatocellular carcinoma patients and is modulated by the E2F7/miR-218-5p axis
Objective: Transcription factor E2F7 exerts suppressive transcription effects and was validated as highly expressed in hepatocellular carcinoma (HCC) in our previous study. Based on the correlation between E2F7 and the dismal clinicopathological features in patients, we investigated the downstream…
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Journal Article
Unlocking immune responses via mitophagy genes: A dual-pronged strategy against hematologic tumors
Mitophagy plays a complex role in cancer biology, particularly in hematologic malignancies. It can promote tumor survival and drug resistance by removing damaged mitochondria and reducing mitochondrial reactive oxygen species (ROS) or conversely inhibit tumor growth by diminishing cellular energy…
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Journal Article
Biological properties and clinical applications of ceftobiprole: Current status and perspective review
Ceftobiprole, a novel fifth-generation cephalosporin, has gained significant attention as an anti-infective therapy because of its broad-spectrum activity against gram-positive and gram-negative bacteria, as well as its effectiveness against drug-resistant strains. This review provides a…
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Journal Article
Evaluation of the performance of a new serum amyloid A chemiluminescence immunoassay
Objective: Serum amyloid A (SAA) is a protein involved in the acute phase of inflammation. SAA expression is upregulated in humans during the acute phase of various viral infections; in addition, SAA can be a useful biomarker to predict the severity and prognosis of COVID-19 patients. This study…
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Journal Article
Diagnostic performance of an immunoblot assay for anti-F-actin antibodies in type 1 autoimmune hepatitis
Autoimmune hepatitis (AIH) is a liver disease of unknown cause characterized by hypergammaglobulinemia, typical or compatible liver histology, the absence of viral hepatitis and the production of autoantibodies. Anti-smooth muscle antibodies (SMAs) detected with indirect immunofluorescence (IIF) in…
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Journal Article
Development of laboratory-based risk scores to predict mortality in patients hospitalized with COVID-19
Objectives: Patient characteristics related to an increased risk of severe coronavirus disease 2019 (COVID-19) have been thoroughly studied since the beginning of the pandemic; however, clinical tools offering rapid and automated predictions of patients’ acute reactions to severe acute respiratory…
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Journal Article
Metabolic reprogramming mechanisms of renal fibrosis in IgG4-related diseases: From immune dysregulation to the imbalance of energy homeostasis
Renal fibrosis in immunoglobulin G4 (IgG4)-related disease (IgG4-RD) results from a complex interaction between dysregulated immune responses and altered cellular metabolism. Characteristic pathological hallmarks include tubulointerstitial fibrosis, dense plasma cell infiltrates, and tubular…
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Journal Article
A pilot cohort study of a microfluidic-based point-of-care bilirubin measurement system
Objective: The concentration of bilirubin in blood or serum is useful for assessing liver function as well as monitoring treatment. This study evaluates the clinical performance of a novel point-of-care (PoC) device for the detection of bilirubin in serum. The PoC device incorporates an integrated…
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Journal Article
Intelligent assisted reproduction: Innovative applications of artificial intelligence in embryo health assessment
Identifying embryos with the highest likelihood of successful implantation is a critical component of the in vitro fertilization (IVF) process. Visual assessments are limited by the subjectivity of embryologists, making consistent evaluation of embryo health challenging with traditional methods…