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Cardiovascular Diabetology. Endocrinology Reports
ISSN 3059-4057 · BioMed Central · 93 artikel di indeks
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Artikel Jurnal
Cardiac autonomic neuropathy in patients with SGA-treated schizophrenia: a randomized controlled trial of 30 weeks’ treatment with semaglutide
Abstract Background Individuals with schizophrenia suffer from reduced life expectancy, primarily due to obesity-related metabolic disorders and cardiovascular disease (CVD). The presence of cardiac autonomic neuropathy (CAN) may contribute to CVD, but CAN is reversible, and it may improve…
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Artikel Jurnal
From metabolism to myocardium: the missing link of admission dysglycemia in early cardiac recovery
Abstract Background Admission dysglycemia is linked to adverse outcomes after ST-elevation myocardial infarction (STEMI); however, its relationship with early recovery of left ventricular (LV) function after primary percutaneous coronary intervention (PPCI), particularly when using stress-adjusted…
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Artikel Jurnal
Prevalence and association of metabolic syndrome components with benign prostate hyperplasia
Abstract Background Benign prostate hyperplasia (BPH) is a non-cancerous enlargement of both glandular and epithelial tissue of the prostate. The disease affects a significant portion of older ages, particularly those above 40 years old. It is thought that in addition to age, there is a…
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Artikel Jurnal
Lipid-based atherogenic indices and their relationship with cardiovascular disease risk in an African population of type 2 diabetes mellitus patients
Abstract Background Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM), driven largely by atherogenic dyslipidaemia. Conventional lipid parameters such as total and low-density lipoprotein cholesterol (LDL-C) do not…
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Artikel Jurnal
Antihypertensive therapy in diabetes mellitus: efficacy, safety, and metabolic impacts in type 1 and type 2 diabetes
Abstract Treating hypertension in diabetic patients with antihypertensive medications should be done with careful consideration because these medications may interfere with macro- and microvascular complications of diabetes, such as myocardial infarction, stroke, and diabetic nephropathy. Some…
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Artikel Jurnal
Efficacy and safety of orforglipron, an oral small-molecule GLP-1 receptor agonist, on cardiometabolic outcomes: a meta-analysis and systematic review
Abstract Background Obesity and type 2 diabetes are the primary drivers of atherosclerotic cardiovascular disease (ASCVD), the leading cause of death worldwide. Injectable GLP-1 receptor agonists reduce major adverse cardiovascular events. Yet for many individuals, injection hesitancy remains a…
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Artikel Jurnal
Phenotypic age metrics for risk stratification of chronic disease burden and all-cause mortality in adults
Abstract Background Phenotypic age gap (PAG) and phenotypic age acceleration (PhenoAgeAccel) are measures of biological ageing that have been linked to adverse health outcomes. However, their relationships with common chronic diseases and mortality in nationally representative populations remain…
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Type 1 diabetes and cardiovascular medicine
Abstract There are an estimated 9.5 million people living with type 1 diabetes (T1D) globally, with cardiovascular disease (CVD) remaining a major cause of morbidity and mortality despite advances in care. Atherosclerosis occurs earlier in people with T1D and those with T1D-onset in early childhood…
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Among individuals who die of COVID-19, is the percentage who had diabetes actually higher than in those dying of other viral infections?
Abstract Background Early in the COVID-19 pandemic, mainstream news outlets reported that 30–40% of all coronavirus deaths in the United States occurred among individuals with diabetes. This statistic happens to reflect the approximate prevalence of diabetes in older adults, the age group at…
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Effects of SGLT2 inhibitors on cardiac structure and function in stage A and B heart failure with type 2 diabetes: a systematic review and meta-analysis
Abstract Background Stage A and B heart failure (HF) in type 2 diabetes (T2DM) represents a critical window for prevention. Although SGLT2 inhibitors (SGLT2i) are recommended for early HF risk reduction, their direct structural effects on pre-symptomatic myocardium remain insufficiently…
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Artikel Jurnal
From dual to quintuple agonism for next-generation pharmacology to treat obesity and type 2 diabetes: synergistic incretin and nuclear receptor signaling
Abstract Receptor-targeted polypharmacology is emerging as a promising strategy for the treatment of obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis. GLP-1–GIP–lanifibranor, a unimolecular conjugate combining GLP-1R/GIPR co-agonism with pan-PPAR activation, enables…
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Artikel Jurnal
Association between the atherogenic index of plasma trajectory and risk of cardiovascular diseases among hypertensive patients: a prospective cohort study
Abstract Background Cardiovascular disease (CVD) remains the leading cause of global mortality, with hypertension and dyslipidemia synergistically exacerbating the atherogenic risk. The atherogenic index of plasma (AIP), calculated as log (triglycerides/HDL-C), reflects lipid-driven…
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Artikel Jurnal
Prevalence of hyperuricemia among patients with non-communicable diseases in Ethiopia: a systematic review and meta-analysis
Abstract Background Hyperuricemia is one of the driving factors for the onset and progression of cardiovascular diseases, type 2 diabetes and hypertension. However, hyperuricemia is not measured regularly for these patients, and its worsening effect is underestimated. Thus, this systematic review…
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Clinical characteristics and outcomes of diabetic ketoacidosis in patients with type 2 diabetes during acute systemic stress
Abstract Background Many reports indicate that diabetes is one of the main risk factors for COVID-19 complications. Nevertheless, few studies have examined how DKA develops in T2DM patients who have SARS-CoV-2 infection. Objectives This study aimed to assess β-cell function, identify risk factors…
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Association of acylcarnitine species and diabetes incidence in a population-based apparently healthy cohort
Abstract Background Current diabetes risk scores often fail to detect early metabolic changes. Acylcarnitines species (ACs), intermediates of mitochondrial fatty acid oxidation, may indicate early dysregulation in diabetes, but prospective evidence is limited. We investigated the associations…
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Artikel Jurnal
Updated perspectives on vitamin D deficiency, screening, supplementation and clinical guidance
Abstract Vitamin D functions like a hormone and plays a crucial role in regulating calcium levels and maintaining normal bone metabolism. A deficiency of vitamin D can lead to an increased risk of fractures, osteoporosis and osteomalacia that’s why research has linked vitamin D deficiency to…
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Artikel Jurnal
Sex-specific roles of insulin-like growth factor-1, lean mass and fat mass in type 2 diabetes prevention: Mendelian randomization studies in Western and East Asian populations
Abstract Background Sex-specific effects of body composition and its drivers, including insulin-like growth factor-1 (IGF-1), on type 2 diabetes mellitus (T2DM) are understudied across ethnicity. We assessed the role of IGF-1 in T2DM and mediation by lean or fat mass, by sex in Western and East…
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Artikel Jurnal
Estimated glucose disposal rate and risk of first myocardial infarction in people with diabetes
Abstract Background The estimated glucose disposal rate (eGDR), calculated from glycated hemoglobin (HbA1c), hypertension status and BMI, is a proxy for insulin resistance. We examined the association between eGDR and the risk of first myocardial infarction (MI) and post-MI mortality in individuals…
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Artikel Jurnal
Acute vascular redox modulation by SGLT2 inhibition in non-diabetic patients
Abstract Background Coronary angiography induces oxidative stress through contrast media exposure and ionizing radiation, potentially contributing to vascular and renal injury. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) exert antioxidant and anti-inflammatory effects beyond glycemic…
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Artikel Jurnal
Pulmonary adverse events associated with GLP-1 receptor agonists: a systematic review of respiratory safety signals
Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are among the most rapidly growing drug classes in contemporary medicine, approved for type 2 diabetes mellitus (T2DM) and obesity management. Although gastrointestinal adverse effects are well characterised, the pulmonary…