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Bioscience Insights
ISSN 3080-3489 · PATHWAY SCHOLARS INSTITUTE (SMC-PRIVATE) LIMITED · 21 artikel di indeks
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Artikel Jurnal
EXPLORING THE ROLE OF NUTRITION IN PREVENTING CHRONIC DISEASES: A CASE STUDY ON THE IMPACT OF MEDITERRANEAN DIET ON CARDIOVASCULAR HEALTH
Chronic diseases, particularly cardiovascular diseases (CVD), represent a leading global cause of mortality and morbidity. Nutrition plays a pivotal role in their prevention and management. This study investigates the specific impact of the Mediterranean Diet (MedDiet), a dietary pattern rich in…
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NEUROPROSTHETIC DEVICES FOR ENHANCING MOTOR RECOVERY POST-SPINAL CORD INJURY: A REHABILITATION STUDY
This paper reports the application of neuroprosthetic devices in the determination of their efficacy in the motor rehabilitation of the spinal cord injury (SCI). The study was directed to assess the impact of the devices on motor skills development and the overall result of the rehabilitation. In…
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CHARACTERIZING THE GENETIC RESISTANCE MECHANISMS IN RICE AGAINST RICE BLAST DISEASE: EXPLORING NEW AVENUES FOR DISEASE CONTROL
Rice blast (Magnaporthe oryzae) poses a major threat to global rice production, yet durable, broad‐spectrum resistance remains elusive. Here, we combined high‐throughput phenotyping of 300 diverse indica, japonica, and aus accessions with whole‐genome resequencing (>10× coverage) and pangenome…
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GENETICALLY MODIFIED CROPS AND ENVIRONMENTAL SUSTAINABILITY: A SYSTEMATIC LITERATURE REVIEW
Large-scale use of genetically modified (GM) crops has raised numerous controversies on the sustainability of the crops to the environment in the long run. In this scientific work, the authors review the environmental concerns of GM crops, in terms of biodiversity, non-target organisms, the…
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COMPARATIVE STUDY OF DIFFERENT ORGANIC FERTILIZERS ON QUINOA PERFORMANCE IN MARGINAL SOILS
Quinoa is gaining attention as a climate-resilient crop suitable for cultivation in marginal soils. This study was piloted at the Postgraduate Agricultural Research Station (PARS), University of Agriculture, Faisalabad, during the Rabi season 2024–25 to estimate the effect of various organic…
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STUDYING THE ROLE OF CALCIUM SIGNALING IN PLANT STRESS RESPONSES: INVESTIGATING NEW TARGETS FOR PLANT BIOTECHNOLOGY
Plants perceive and decode environmental stress signals through transient elevations in cytosolic calcium, yet the molecular components that translate these signatures into adaptive responses remain incompletely understood. Here, we combined high-resolution in vivo calcium imaging in…
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NEPHROGENIC DIABETES INSIPIDUS: THE CRUCIAL ROLE OF AQUAPORINS
Nephrogenic diabetes insipidus (NDI) is a disorder marked by the kidney's inability to concentrate urine despite normal or elevated levels of vasopressin, often due to impairments in aquaporin-2 (AQP2) expression or function. This study investigated the molecular, physiological, and clinical…
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EVALUATION OF THE RENIN-ANGIOTENSIN PATHWAY IN PAEDIATRIC HYPERTENSION
This study aimed to evaluate the renin-angiotensin pathway in paediatric hypertension, with the objective of understanding its biochemical, clinical, and genetic associations in children aged 6 to 18 years. Using a cross-sectional design, 84 participants (42 hypertensive and 42 normotensive) were…
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THE IMPACT OF MENTAL HEALTH STIGMA ON TREATMENT SEEKING BEHAVIOR: A STUDY ON THE BARRIERS TO MENTAL HEALTH CARE ACCESS
Mental health stigma remains a formidable barrier to treatment seeking, contributing to a substantial global treatment gap. This study investigates the multifaceted impact of public and self-stigma on individuals' decisions to access mental health care. A quantitative, cross-sectional survey design…
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THE ROLE OF IMMUNOTHERAPY IN CANCER TREATMENT: A COMPARATIVE STUDY OF PD-1 INHIBITORS AND CAR-T CELL THERAPY
Immunotherapy has revolutionized oncology by harnessing the body's immune system to combat cancer. This comparative study evaluates the efficacy, safety, and clinical applicability of two pivotal immunotherapeutic approaches: immune checkpoint inhibitors (specifically PD-1 inhibitors) and adoptive…
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EPIDEMIOLOGICAL TRENDS OF TUBERCULOSIS IN URBAN SLUMS: A PULMONOLOGY-PUBLIC HEALTH PERSPECTIVE
This research paper will examine the epidemiological trends of Tuberculosis (TB) in the urban slums with emphasis on its implications to the practice of public health and its implication to pulmonology. The scientists examined the results of a 5-year period of TB in several communities of the urban…
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HARNESSING ARTIFICIAL INTELLIGENCE FOR PREDICTING AND MANAGING CARDIAC ARREST RISK: INNOVATIONS IN EARLY DETECTION, PREVENTION, AND PERSONALIZED CARE
The sudden breakdown of heart activity has the potential to become fatal. The prediction of cardiac arrest at an early stage enables proper intervention to stop such occurrences or protect patients from experiencing an arrest. Artificial intelligence (AI) and big data technologies have gained…
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LONGITUDINAL STUDY ON EGG LAYING PATTERNS AND MORTALITY RATES OF FAYOUMI, ALBALADY, AND BLACK AUSTRALORP BREEDS IN NARC, PAKISTAN
The objective of this study was to evaluate egg laying performance and mortality rates of three poultry breeds (Fayoumi, Albalady and Black Australorp) under standardized conditions at the National Agricultural Research Centre (NARC), Islamabad, Pakistan. The hens were observed during a 52-week…
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PEPTIDE-BASED DRUGS: SYNTHESIS, MECHANISM OF ACTION, AND POTENTIAL FOR TREATING ENDOCRINE AND METABOLIC DISEASES
Peptide drugs are new medicines with vast potential for the therapy of endocrine as well as metabolic disorders since they are highly specific, less toxic, and have the capability to easily mimic natural biological processes. In our research, new peptide synthesis techniques such as Solid-Phase…
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AI-DRIVEN DRUG DISCOVERY FOR CANCER THERAPY: MACHINE LEARNING MODELS FOR IDENTIFYING NOVEL TARGETS AND OPTIMIZING CHEMOTHERAPY REGIMENS
Transforming drug discovery into an AI for cancer therapy, which uses machine learning (ML) models to identify novel drug targets and optimize chemotherapy regimens, can achieve this. AI is also enabling high-throughput screening, predictive modeling, and biomarker discovery, thereby improving…
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PREVALENCE AND RISK ASSESSMENT OF TRANSFUSION-TRANSMISSIBLE INFECTIONS AMONG BLOOD DONORS IN PAKISTAN
Transfusion of blood and blood components has become a norm in the current medical practice especially when it comes to support during surgical operations or in handling of various medical emergencies or chronic diseases. But, the disadvantage is that it is accompanied with a potential to transmit…
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CHEMISTRY OF ANTIOXIDANTS AND THEIR ROLE IN PREVENTING OXIDATIVE STRESS IN CARDIOVASCULAR AND NEURODEGENERATIVE DISEASES
Oxidative stress constitutes a significant factor in the evolution of almost all cardiovascular and neurodegenerative diseases. The study studies the effects of selected antioxidants such as vitamin C, vitamin E, polyphenols, coenzyme Q10, and curcumin on oxidative stress and protection to the…
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ASSESSING THE IMPACT OF AIR POLLUTION ON RESPIRATORY HEALTH IN MAJOR CITIES OF PAKISTAN: EPIDEMIOLOGICAL TRENDS, RISK FACTORS, AND MITIGATION STRATEGIES
The public health issue of air pollution severely affects the urban areas of Lahore, Karachi, Faisalabad, Islamabad, and Rawalpindi in Pakistan. Various human activities combined with industrial emission sources and brick kiln contaminants and urbanization and combustion activities together result…
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Artikel Jurnal
THE EFFECTS OF SMOKING ON PULMONARY FUNCTION TESTS: A CROSS-SECTIONAL STUDY IN PAKISTAN
The connection between smoking and pulmonary function tests remains partially undefined because additional scrutiny of smoking effects on these assessments is necessary. The main goal of this investigation examined the smoking-related impact on adult measurements from spirometric and diffusion…
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ANALYZING CARDIOVASCULAR DISEASE TRENDS IN PAKISTAN: THE ROLE OF LIFESTYLE CHOICES, SOCIOECONOMIC FACTORS, AND PREVENTIVE HEALTHCARE STRATEGIES
Throughout the past several decades the prevalence of cardiovascular disease (CVD) has continuously risen in Pakistan thus becoming the leading cause of mortality and sickness within the country. This research aimed to identify variables which drive the rising incidence of cardiovascular disease…