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Artikel Jurnal Teks lengkap
Antifungal interventions and clinical outcomes: A review
Fungal infections pose a significant risk to public health since they are linked to high rates of illness and death, particularly in immunocompromised individuals. Therapy is difficult because there are few antifungal drugs available and many of them are harmful. Fungi have also evolved defence…
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Unveiling the therapeutic potential of Ipomoea batatas Lam: A journey from preclinical research to clinical applications
Ipomoea batatas Lam, commonly known as sweet potato, has garnered recognition for its significant therapeutic potential, which can be largely ascribed to its abundant array of bioactive secondary metabolites. Among these phytoconstituents, flavonoids, anthocyanins, carotenoids and terpenoids have…
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The effect of gingival inflammation on salivary cytochrome P450 enzymes in children: A case-control study
Background/Aim: Gingival inflammation in children involves characteristic changes of the salivary composition that reflect not only weakened local defence factors but also increased defensive reflexes. This study aimed to compare the salivary parameters cytochrome concentration, density and flow…
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Co-crystals for drug design: A logical approach for modifying physicochemical properties of drugs
Drug design plays a critical role in the pharmaceutical industry, addressing the limitations of many compounds with medicinal properties that cannot serve as an effective active pharmaceutical ingredient. Extensive research has been conducted to overcome this challenge, with co-crystals emerging as…
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Artikel Jurnal Teks lengkap
Pharmacovigilance and adverse drug reactions in type 2 diabetes mellitus: Insights from a tertiary care hospital in Central India
Background/Aim: Type 2 diabetes mellitus (T2DM) is a chronic condition that frequently necessitates prolonged pharmacological treatment and is frequently complicated by polypharmacy and comorbid conditions. These components elevate the likelihood of adverse drug reactions (ADRs) that demand active…
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Artikel Jurnal Teks lengkap
Allocation of stem cell alterations in spermatogenesis of male rats affected by zymafluor and detection of reverse effect of vitamin E on testis histology using immunohistochemical techniques
Background/Aim: Zymafluor is a proven protective agent against dental caries and it is a naturally occurring agent present in water and soil. Aim of this study was to analyse the detrimental effect of sodium fluoride and opposing effect of vitamin E on spermatogenesis on testicular tissue of male…
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Artikel Jurnal Teks lengkap
COVID-19 vaccine safety in adults: A narrative review of adverse reactions in ASEAN countries
The spread of the SARS-CoV-2 virus, known as the COVID-19 virus, which causes the coronavirus disease 2019 known as "COVID-19", has led to a rapid response from governments around the world. In response to the significant threat it presents to global health, comprehensive strategies have been…
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Emerging biomaterial strategies for giant cell arteritis: Challenges and future outlooks
Giant cell arteritis (GCA) is a common vasculitis of the big arteries that affects people as they get older and it usually results in potentially serious problems like vision loss and stroke. Steroids remain the cornerstone of GCA treatment, although long-term steroid use is associated with…
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A narrative review on preclinical/clinical trials on aducanumab
The most widespread type of dementia, Alzheimer's disease (AD), is predicted to triple in global prevalence by 2050. AD has a substantial societal and economic impact across the world, negatively affecting both patients and their caregivers, as the disorder has few therapeutic alternatives…
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Artikel Jurnal Teks lengkap
Effect of deuterated aspirin treatment of obese Iraqi patients with blood hyperviscosity syndrome
Background/Aim: Hyperviscosity syndrome (HVS) is a predictor of blood flow resistance and blood viscosity, density or thickness. A number of factors that influence blood viscosity have been identified. This study aimed to compare the effects of the deuterated aspirin (aspirin-D) to standard aspirin…
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Phytochemical heterocycles in depression management: A sustainable strategy
According to WHO, depression is raising globally and expected as global burden by 2030. After COVID-19, drastic incline led to 17 % of total world population that suffered from well-known mental disorder depression and around 140,000 suicides annually attributed to depression. Owing to the diverse…
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Anticancer activity of Opuntia cochenillifera extract against triple-negative breast cancer cells via apoptosis induction and bioinformatics-based target prediction
Background/Aim: Breast cancer remains one of the most commonly diagnosed cancers among women worldwide and is a significant public health concern. Aim of this study was to investigate the in vitro anticancer activity of Opuntia cochenillifera ethanolic extract (EOC) against triple-negative breast…
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Artikel Jurnal Teks lengkap
Global research trends and risk factors for loneliness in older adults
Loneliness was defined as an unpleasant feeling for a person when there is a gap between expectations of desired social connection with actual number of social relationships owned, both in terms of quantity and especially the quality. This research was systematic literature review with bibliometric…
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Prevalence and associated factors of depression in women in the last trimester of pregnancy: A cross-sectional study in a southern province of Vietnam
Background/Aim: Depression during pregnancy is a significant public health issue, particularly in the third trimester when women experience various physical and emotional changes. This study aimed to investigate the prevalence of depression in women in the final trimester of pregnancy, as well as…
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Artikel Jurnal Teks lengkap
Gunshot wound: Pathogenesis
Gunshot wounds remain one of the most complex types of combat injuries. A gunshot wound is a dynamic system in which the initial mechanical destruction of tissue is only the starting point of a complex and multi-level process. Subsequently, the wound site steadily transforms and the volume of…
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Case series of Burkholderia pseudomallei infections in critically ill patients: Unveiling key challenges
Melioidosis remains a diagnostic challenge in tropical regions due to its broad clinical spectrum. This series presents seven diabetic individuals from an endemic area with diverse forms of the disease, including pulmonary, visceral, soft tissue and lymph node involvement. Laboratory confirmation…
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Artikel Jurnal Teks lengkap
Determinants of health-related quality of life in mothers of children with autism spectrum disorder in Bangladesh
Background/Aim: Autism spectrum disorder (ASD) has a significant impact on the quality of life of children with this disorder as well as their mothers. ASD prevalence in Bangladesh has been estimated to be 0.15-0.8 %, but the health-related quality of life (HRQoL) of mothers having children with…
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Artikel Jurnal Teks lengkap
Pathophysiological pathways linking diabetes to cardiac hypertrophy: From insulin resistance to personalised cardioprotection
Diabetes and cardiac hypertrophy are closely interconnected, sharing overlapping metabolic and cardiovascular pathways. This review aimed to investigate the underlying mechanisms that drive this relationship and to evaluate current diagnostic and therapeutic strategies with the goal of improving…
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Artikel Jurnal Teks lengkap
The silent crisis: Economic burden of genetic disease diagnosis in lowand middle-income countries (LMICs)
Genetic disorders, although secondary to infectious and non-communicable diseases in the global health priority agenda, are an important drain, albeit ill-defined, on the economies of lowand middle-income countries (LMICs) and on their health resources. The economic costs of diagnosing a genetic…
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Artikel Jurnal Teks lengkap
Feasibility of pulmonary valve balloon dilation as palliative procedure in children with symptomatic tetralogy of Fallot
Background/Aim: Tetralogy of Fallot (TOF) is the most prevalent cyanotic congenital heart disease, for which surgical correction remains the definitive treatment. Balloon dilatation of the pulmonary artery provides recognised immediate palliative benefits in selected TOF patients. Nonetheless…
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