54.613 hasil
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Artikel Jurnal Teks lengkap
Pharmacological potential of Inonotus obliquus: An integrative review of antitumour, immunomodulatory and anti-inflammatory effects
Inonotus obliquus (Chaga mushroom), long used in traditional medicine, has recently gained substantial scientific attention due to its diverse pharmacological activities. While numerous preclinical studies exist, the lack of a comprehensive understanding of its molecular mechanisms continues to…
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Effects and mechanisms of amino acids in Alzheimer's disease: A narrative review
Alzheimer's disease is the most common form of dementia, a complex and progressive neurodegenerative disorder that slowly decreases memory, thinking skills and the ability to perform the simplest tasks. It is characterised by the formation of extracellular amyloid-beta (Aβ) plaques and…
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Phytochemical screening of ethanolic extract of Kopasanda (Chromolaena odorata (L) RM King and H Rob) leaves and its anti-hyperglycaemic activity in the mouse model of hyperglycaemia
Background/Aim: Hyperglycaemia is a defining feature of diabetes mellitus, a chronic metabolic disorder. Complications of diabetes mellitus may include vascular issues both macrovascular and microvascular as well as nervous system abnormalities or neuropathy. The herb "Kopasanda" (Chromolaena…
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Personalised anaesthesia, arterial blood gases and tissue hypoxia: modulating postoperative regeneration and healing
The fundamental limiting factor of major surgery is the body's ability to regenerate and heal tissue after it has been operated on, but this process must take its own course. Recent evidence is available to show that the method of anaesthesia employed during operative procedures and in particular…
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Post-polypectomy syndrome (PPS): A case report
A 51-year-old female with unremarkable medical history developed right iliac fossa pain and fever one day post-polypectomy procedure. Management involved hospital admission for monitoring, supportive care with intravenous fluids and "nothing by mouth (NPO)", broad-spectrum intravenous antibiotics…
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Regulatory effects of chromium picolinate and phytochemicals on blood glucose via AMPK pathway activation
The study examines the scientific work and clinical reports to emphasise the roles of Brassica juncea in glucose metabolism and glycogen synthesis, Gymnema sylvestre in insulin secretion and beta-cell regeneration and chromium picolinate in chromodulin synthesis and insulin receptor activation…
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Functional outcome of hooked/locked patellar plate versus tension band wiring in treatment of patellar fractures: A comparative case series
Background/Aim: Patella fractures significantly compromise the knee joint function and usually require surgical fixation to restore the knee ex-tensor mechanism. Tension band wiring (TBW) and locked patellar plate (LPP) are widely used surgical methods for the fixation of these fractures. Within…
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Gene variants that may enhance the effectiveness of non-Hodgkin lymphoma therapy: Genomic and bioinformatics approaches
Background/Aim: Non-Hodgkin lymphoma (NHL) is a cancer of the lymphatic system with a high incidence rate globally. Patient responses to therapies such as chemotherapy and immunotherapy often vary, which is thought to be related to individual genetic differences. The development of genomic and…
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Global research trends on herbal medicine for hypertension: A bibliometric and visual analysis from 1979 to 2025
Hypertension is a major risk factor for cardiovascular disease globally. Despite widespread availability of conventional treatments, blood pressure control rates remain low globally. Herbal medicine is an alternative or complementary medicine that is gaining increasing attention. Scientific…
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Integrative analysis of VEGFA gene expression and drug targeting in kidney renal clear cell carcinoma (KIRC)
Background/Aim: Vascular endothelial growth factor A (VEGFA) plays an important role in angiogenesis and is known to have a strong association with the development of various types of cancer, including kidney renal clear cell carcinoma (KIRC). The purpose of this study was to analyse VEGFA…
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Pharmacotherapeutic strategies in high-risk pregnancy: Balancing maternal and foetal safety
Pharmacotherapy in high-risk pregnancies necessitates customised, evidence-based strategies to provide optimal results for women and their infants. A keen awareness that physiological changes during pregnancy can affect medication pharmacokinetics necessitates careful consideration of dose and…
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An insight into skincare and antiaging products derived from marine origin
Marine resources are attracting significant attention from the cosmetics sector as a source of active ingredients. The oligo-elements like iron, copper and zinc, as well as proteins, amino acids, carbohydrates and vitamins A, B and C, are abundant in both microand macro-algae. These active…
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A new approach to amniotic band disease
Background/Aim: Amniotic band disease (ABD) is a rare condition, generally associated with three types of anomalies: malformations, deformities and amputations. Several theories have been put forward, the extrinsic theory being the most widely adopted. The aim of the study was to clarify the…
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Retrieval of migrated guidewire extending from right ventricular apex to the inferior vena cava via pigtail-assisted snaring
Intravascular embolisation of foreign bodies (FB) is a rare, serious complication that may occur during central venous line insertion. A 39-year-old male in a critical condition presented to casualty department with a through-and-through chest gunshot wound. Chest X-ray showed left haemothorax; an…
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The development of polyclonal antibody against glucose-6-phosphate dehydrogenase (G6PD) for G6PD deficiency newborn screening in Indonesia
Background/Aim: Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an enzymatic disorder affecting carbohydrate metabolism, is a common cause of haemolytic anaemia and jaundice in newborns. Despite the proven benefits of G6PD screening, Indonesia faces significant challenges in implementing…
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Phytochemical profiling and antioxidant assessment of Indian Cymbalaria muralis extracts
Background/Aim: Cymbalaria muralis (ivy-leaved toadflax) is a small creeping plant native to Europe, South Africa and some regions of India. Indian Cymbalaria muralis is recognised as a plant of traditional importance, but scientific literature available for its pharmacological activities as well…
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Oolong tea-derived manganese nanoparticles as an alternative oral negative contrast agent for MRCP imaging
Background/Aim: Conventional natural manganese contrast agent for magnetic resonance cholangiopancreatography (MRCP) have produced suboptimal visualisation of the gastric, duodenum and biliary system. While various studies have explored manganese-based media, limited research has focused on…
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The role of endocrine disruptors and environmental chemicals in causing cancer: Focusing on genetic and epigenetic mechanisms
Endocrine-disrupting chemicals (EDCs) and environmental pollutants are ubiquitous and increasingly linked to the aetiology of cancer. This review synthesises existing evidence on the carcinogenic potential of EDCs, including bisphenols, phthalates, pesticides, heavy metals and persistent organic…
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Planned learning situations in preschool
Planned learning in preschool involves situations based on a social process in which children and adults jointly explore possible solutions and negotiate them. The educator plays a key role in supporting and organizing these situations by creating an inspiring learning environment, fostering…
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Principles of the current organization and arrangement of primary schools in the Raška region (1912 - 2000)
The subject of research in this paper was related to the principles of the current organization and arrangement of elementary schools in the Raška region (1912-2000). The topic of the paper enters the domain of searching for the essential conditions of elementary schools at one time and for a…
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