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Journal Article
Matrix nanoalignment programs macrophage vesicular immunity through TRPV2 mechanogating
The extracellular matrix (ECM) undergoes extensive architectural remodeling during tumor progression, generating nanoscale alignment cues that profoundly influence behaviors of immune cells. However, whether ECM nanoarchitecture directly programs their immune secretory functions remains poorly…
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Journal Article
Efineptakin alfa (NT-I7) improves overall survival and induces immune niches in murine tumors
Tertiary lymphoid structures (TLSs) are emerging as good predictive biomarkers of response to cancer immunotherapy. However, therapeutic strategies to induce these structures are currently limited. We evaluated the therapeutic benefit of efineptakin alfa (NT-I7), a long-acting form of IL-7, as well…
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Journal Article
VCP at the crossroads of UPS and autophagy in cancer
Proteostasis is maintained by the coordinated action of the ubiquitin–proteasome system (UPS) and autophagy–lysosome pathways. Valosin-containing protein (VCP/p97), an AAA + unfoldase, sits at its intersection by extracting ubiquitinated clients and assembling cofactor-defined complexes that…
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Journal Article
Rewiring redox defense: Nrf2-driven antioxidant signaling as a gateway to programmed cell death activation in colorectal cancer
Nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant and phase II detoxification genes, plays a dual role in colorectal cancer (CRC) progression by maintaining redox homeostasis while paradoxically fostering chemoresistance. Programmed cell death (PCD) pathways…
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Journal Article
Steatotic liver-derived extracellular vesicles deliver ACSL4 to potentiate hepatic ischemia–reperfusion injury by orchestrating a ferroptosis-mitochondrial apoptosis cascade
Steatotic liver grafts exhibit heightened susceptibility to hepatic ischemia–reperfusion injury (HIRI), contributing to poor outcomes in liver transplantation; however, the underling mechanisms remain incompletely defined. Here, we demonstrate that extracellular vesicles derived from steatotic…
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Journal Article
Functions of exosome-derived noncoding RNA-encoded polypeptides/proteins in human diseases
Exosomes are nanoscale vesicles that are ubiquitously present in biological fluids and exhibit remarkable stability, carrying a diverse array of biologically active molecules, including various RNAs, DNAs, and proteins. Exosomes are crucial mediators of intercellular signaling and exert extensive…
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Journal Article
Influence of oncogenic drivers and signaling pathways on immune checkpoint inhibitor efficacy in NSCLC
Non-small cell lung cancer (NSCLC) is characterized by intricate genetic modifications and mechanisms that allow it to evade immune detection, which complicates the pursuit of lasting therapeutic responses. The effectiveness of treatments is greatly affected by the interaction between tumor genetic…
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Journal Article
ONC201/dordaviprone for H3 K27M-mutant tumors: Discovery, mechanisms, therapeutic potential, and future directions
ONC201 (dordaviprone) has recently received accelerated approval for the treatment of recurrent H3 K27M–mutant diffuse midline glioma. Originally identified as TRAIL-inducing compound 10 (TIC10), ONC201 is a first-in-class small molecule distinguished by a unique pharmacologic profile. It promotes…
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Journal Article
Necroptosis-related diseases are regulated by the unfolded protein response during endoplasmic reticulum stress
In recent years, research has highlighted that necroptosis plays a significant role in various diseases, suggesting that studying the pathways of necroptosis may offer novel avenues for developing treatments for these conditions. The classical necroptosis pathway involves the activation and…
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Journal Article
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights
Metabolic reprogramming is an important factor contributing to tumor medication resistance and recurrence in cancer cells. There is ample proof that metabolic remodeling is vital in colorectal cancer’s genesis, progression, and resistance to treatment. The molecular processes behind changes in…
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Journal Article
Lactylation: Metabolic epigenetic regulation and cell death mechanisms in myocardial ischemia‒reperfusion injury
One important pathogenic process that contributes to subsequent damage after myocardial infarction (MI) revascularization is myocardial ischemia/reperfusion injury (MI/RI). Its underlying mechanisms are controlled by traditional post-translational modifications (PTMs) like acetylation, methylation…
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Journal Article
Autosomal dominant gain-of-function mutations in LCP1 cause a syndromic neutropenia and immunodeficiency
Actin cytoskeleton defects underlie immuno-actinopathies. We identified three patients with heterozygous LCP1 gain-of-function mutations (L362F, A365D) causing activated LCP1-associated immunodeficiency syndrome, characterized by congenital neutropenia, variable combined immunodeficiency, and…
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Journal Article
PINK1 deficiency exacerbates age-related bone loss in association with enhanced inflammatory adipocyte differentiation
Age-related bone loss contributes to frailty, fractures, and increased mortality in the elderly, yet current osteoporosis treatments have limited long-term efficacy. Mitochondrial dysfunction is a hallmark of skeletal aging, but its role in mesenchymal lineage commitment remains unclear. Here, we…
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Journal Article
ZO-2 blocks the localization of PGAM5 protein to the mitochondrial membrane and suppresses pancreatic cancer malignancy through metabolic reprogramming
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death with limited treatment options, and there is an urgent need to develop effective therapeutic strategies. The zonula occludens-2 (ZO-2) protein is a member of the tight junction protein family, and its…
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Journal Article
Single-cell sequencing-guided discovery of narciclasine as a dual VCAM-1/ICAM-1 inhibitor for atherosclerosis management
Atherosclerosis (AS) remains a leading cause of cardiovascular morbidity and mortality worldwide, with current treatments focused primarily on reducing low-density lipoprotein levels while failing to repair damaged endothelial cells, thus highlighting the urgent need for novel therapeutic drugs. To…
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Journal Article
High-throughput chemical screen identifies epothilone B in modulating inflammatory bowel disease by triggering neutrophil apoptosis
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract characterized by a complex interplay of genetic, environmental, and immunological factors. Neutrophils, as a key component of the innate immune system, play a critical role in IBD pathogenesis due to…
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Journal Article
Micellar LYTAC-engineered bionic coatings abrogate RANK-dependent osteocatabolism and boost fibrillogenesis-mimetic mineral accretion for empowering osteoporotic osseointegration
Patients with osteoporosis are highly susceptible to fractures that often require implant fixation and stabilization. However, excessive osteoclast activity under osteoporotic conditions accelerates bone resorption at the bone-implant interface, severely compromising implant osseointegration…
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Journal Article
Targeted inhibition of inflammatory liver macrophages with a multifunctional nanoparticle ameliorates metabolic dysfunction–associated steatohepatitis
Despite metabolic dysfunction–associated steatohepatitis (MASH) being a significant global health concern, there are few effective ways to prevent or treat MASH. Evidence from preclinical and clinical studies suggests that inflammatory polarization of Kupffer cells (KCs) and infiltration of…
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Journal Article
Data-driven surrogate modeling of FLUKA-generated ambient dose equivalent distributions in an asymmetric proton accelerator shielding system
Accurate determination of spatial ambient dose equivalent H*(10) distributions in high-energy proton accelerator facilities is essential for radiation protection and shielding design. In this study, spatial ambient dose equivalent H*(10) distributions produced under a proton beam-loss scenario were…
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Journal Article Full text
Structure-property relationships in 2D/quasi-2D lead-free halide double perovskites for optoelectronic devices
Two-dimensional (2D) and quasi-2D lead-free halide double perovskites (LFHDPs) have gained significant attention as promising alternatives to conventional lead-based perovskites due to their superior environmental stability, reduced toxicity and versatile structural chemistry. This review provides…
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