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CAR-T cell therapy for cancer: current challenges and future directions
Chimeric antigen receptor T (CAR-T) cell therapies have transformed the treatment of relapsed/refractory (R/R) B-cell malignancies and multiple myeloma by redirecting activated T cells to CD19- or BCMA-expressing tumor cells. However, this approach has yet to be approved for acute myeloid leukemia…
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Cancer statistics, 2025
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes using incidence data collected by central cancer registries (through 2021) and mortality data…
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DESI 2024 VI: cosmological constraints from the measurements of baryon acoustic oscillations
Abstract We present cosmological results from the measurement of baryon acoustic oscillations (BAO) in galaxy, quasar and Lyman- α forest tracers from the first year of observations from the Dark Energy Spectroscopic Instrument (DESI), to be released in the DESI Data Release 1. DESI BAO provide…
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The Influence of Ectotrophic Mycorrhizal Fungi on the Resistance of Pine Roots to Pathogenic Infections. I. Antagonism of Mycorrhizal Fungi to Root Pathogenic Fungi and Soil Bacteria
Antagonism of ectotrophic mycorrhizal fungi to Phytophthora cinnamomi, other root pathogenic fungi, and soil bacteria was examined. In agar plate tests, Laccaria laccata, Lactarius deliciosus, Leucopaxillus cerealis var. piceina, Pisolithus tinctorius, and Suillus luteus inhibited growth of nearly…
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Negation in English and other languages
Synopsis: Otto Jespersen's landmark study of negation provides a wide-ranging analysis of how languages express negative meaning. Drawing on an impressive array of historical texts and comparative examples, primarily from Germanic and Romance languages, Jespersen examines the forms, functions, and…
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Researching Society and Culture
Introduction - Clive Seale PART ONE: RESEARCH CONTEXTS Selected Issues in the Philosophy of Social Science - David Lazar Politics, Identities and Research - Suki Ali et al Developments in Social Theory - Paul Filmer et al Research and Social Theory - David Silverman Research and Social Policy -…
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Behavioral Game Theory
Principles of Behavioral Economics, written by an acknowledged leader in the field, provides a comprehensive introduction to one of the most exciting areas of modern economics. It demonstrates how models of economic theory can be enriched by using interdisciplinary insights from psychology…
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A Glance on Changing Workplace Dynamics Post Covid-19 in India: A Review of Psychological Employee Withdrawal Behavior
Advances in Consumer Research (Abbreviated as Adv. Consum. Res.) is a distinguished journal based in the United States and published by Sheridan Books. The journal is highly regarded in the academic community, particularly within the fields of Business, Management, and Accounting, with a specific…
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8 The Precariat The New Dangerous Class?
For the first time in history, the mainstream left has no progressive agenda. It has forgotten a basic principle. Every progressive political movement has been built on the anger, needs and aspirations of the emerging major class. Today that class is the precariat.
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Principles of Biological Autonomy
A new, updated edition of the 1979 classic from one of the foremost authors in cognitive science and theoretical biology, with the original text as well as more than 200 citations to current scientific developments. Francisco Varela’s Principles of Biological Autonomy was a groundbreaking text when…
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Toward expert-level medical question answering with large language models
Large language models (LLMs) have shown promise in medical question answering, with Med-PaLM being the first to exceed a 'passing' score in United States Medical Licensing Examination style questions. However, challenges remain in long-form medical question answering and handling real-world…
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Accurate predictions on small data with a tabular foundation model
Abstract Tabular data, spreadsheets organized in rows and columns, are ubiquitous across scientific fields, from biomedicine to particle physics to economics and climate science 1,2 . The fundamental prediction task of filling in missing values of a label column based on the rest of the columns is…
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Breast cancer: pathogenesis and treatments
Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes of malignancy-related deaths in women. The increasingly nuanced molecular subtypes of breast cancer have enhanced the comprehension and precision treatment of this…
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The Essential Guide to Doing Your Research Project
PART ONE: TAKING THE LEAP INTO THE RESEARCH WORLD The challenge of tackling a research project So what is this thing called research and why do it? The need for research knowledge The potential of research knowledge Delving into the 'construct' of research Ontology and epistemology Competing…
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Software Update: The ORCA Program System—Version 6.0
ABSTRACT Version 6.0 of the ORCA quantum chemistry program suite was released in July 2024. ORCA 6.0 is a major turning point in the history of the program since it represents a near complete rewrite of the code base that leads to: (1) major performance improvements, (2) a clean and highly…
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Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021
BACKGROUND: Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing an evidence base for policy change. In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from…
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2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep…
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DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning
Abstract General reasoning represents a long-standing and formidable challenge in artificial intelligence (AI). Recent breakthroughs, exemplified by large language models (LLMs) 1,2 and chain-of-thought (CoT) prompting 3 , have achieved considerable success on foundational reasoning tasks. However…
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CONSORT 2025 statement: updated guideline for reporting randomised trials
BACKGROUND: Well designed and properly executed randomised trials are considered the most reliable evidence on the benefits of healthcare interventions. However, there is overwhelming evidence that the quality of reporting is not optimal. The CONSORT (Consolidated Standards of Reporting Trials)…
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