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Risk Alleles of USF1 Gene Predict Cardiovascular Disease of Women in Two Prospective Studies
Upstream transcription factor 1 (USF1) is a ubiquitously expressed transcription factor controlling several critical genes in lipid and glucose metabolism. Of some 40 genes regulated by USF1, several are involved in the molecular pathogenesis of cardiovascular disease (CVD). Although the USF1 gene…
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HIV-1 Vpu Promotes Release and Prevents Endocytosis of Nascent Retrovirus Particles from the Plasma Membrane
The human immunodeficiency virus (HIV) type-1 viral protein U (Vpu) protein enhances the release of diverse retroviruses from human, but not monkey, cells and is thought to do so by ablating a dominant restriction to particle release. Here, we determined how Vpu expression affects the subcellular…
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Human Retroviral Host Restriction Factors APOBEC3G and APOBEC3F Localize to mRNA Processing Bodies
APOBEC3G is an antiviral host factor capable of inhibiting the replication of both exogenous and endogenous retroviruses as well as hepatitis B, a DNA virus that replicates through an RNA intermediate. To gain insight into the mechanism whereby APOBEC3G restricts retroviral replication, we…
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Correction: Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex
Chronic in vivo imaging of fluorescent-labeled neurons in adult mice reveals extension and retraction of dendrites in GABAergic non-pyramidal interneurons of the cerebral cortex.
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Artikel Jurnal Teks lengkap
So You Want Your Child to Be a Genius?
Geneticist Jonathan Flint reviews David Plotz's book The Genius Factory: The Curious History of the Nobel Prize Sperm Bank.
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Artikel Jurnal Teks lengkap
Open Access Increases Citation Rate
PLoS Biology has published a research article that investigates a bibliometric rather than a biological question: do open-access articles have a citation advantage?
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Artikel Jurnal Teks lengkap
Model Selection and the Molecular Clock
A brief overview of the methods used to determine phylogenetic distances sets the stage for understanding new research published in PLoS Biology.
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Artikel Jurnal Teks lengkap
Chromosomal Organization: Mingling with the Neighbors
Jacob Aten and Roland Kanaar highlight recent advances in understanding the physical organization of chromosomes in the nucleus.
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Artikel Jurnal Teks lengkap
Neuronal Oscillations Enhance Stimulus Discrimination by Ensuring Action Potential Precision
Although oscillations in membrane potential are a prominent feature of sensory, motor, and cognitive function, their precise role in signal processing remains elusive. Here we show, using a combination of in vivo, in vitro, and theoretical approaches, that both synaptically and intrinsically…
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Artikel Jurnal Teks lengkap
Plant Volatiles, Rather than Light, Determine the Nocturnal Behavior of a Caterpillar
Although many organisms show daily rhythms in their activity patterns, the mechanistic causes of these patterns are poorly understood. Here we show that host plant volatiles affect the nocturnal behavior of the caterpillar Mythimna separata. Irrespective of light status, the caterpillars behaved as…
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Artikel Jurnal Teks lengkap
Citation Advantage of Open Access Articles
Open access (OA) to the research literature has the potential to accelerate recognition and dissemination of research findings, but its actual effects are controversial. This was a longitudinal bibliometric analysis of a cohort of OA and non-OA articles published between June 8, 2004, and December…
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Artikel Jurnal Teks lengkap
Immune Protection of Nonhuman Primates against Ebola Virus with Single Low-Dose Adenovirus Vectors Encoding Modified GPs
Background: Ebola virus causes a hemorrhagic fever syndrome that is associated with high mortality in humans. In the absence of effective therapies for Ebola virus infection, the development of a vaccine becomes an important strategy to contain outbreaks. Immunization with DNA and/or…
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Artikel Jurnal Teks lengkap
Statistics of Knots, Geometry of Conformations, and Evolution of Proteins
Like shoelaces, the backbones of proteins may get entangled and form knots. However, only a few knots in native proteins have been identified so far. To more quantitatively assess the rarity of knots in proteins, we make an explicit comparison between the knotting probabilities in native proteins…
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Reverse Engineering the Gap Gene Network of Drosophila melanogaster
A fundamental problem in functional genomics is to determine the structure and dynamics of genetic networks based on expression data. We describe a new strategy for solving this problem and apply it to recently published data on early Drosophila melanogaster development. Our method is orders of…
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Iterative Reconstruction of Transcriptional Regulatory Networks: An Algorithmic Approach
The number of complete, publicly available genome sequences is now greater than 200, and this number is expected to rapidly grow in the near future as metagenomic and environmental sequencing efforts escalate and the cost of sequencing drops. In order to make use of this data for understanding…
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Predicting Shine–Dalgarno Sequence Locations Exposes Genome Annotation Errors
In prokaryotes, Shine–Dalgarno (SD) sequences, nucleotides upstream from start codons on messenger RNAs (mRNAs) that are complementary to ribosomal RNA (rRNA), facilitate the initiation of protein synthesis. The location of SD sequences relative to start codons and the stability of the…
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Artikel Jurnal Teks lengkap
Diverse Chromatin Remodeling Genes Antagonize the Rb-Involved SynMuv Pathways in C. elegans
In Caenorhabditis elegans, vulval cell-fate specification involves the activities of multiple signal transduction and regulatory pathways that include a receptor tyrosine kinase/Ras/mitogen-activated protein kinase pathway and synthetic multivulva (SynMuv) pathways. Many genes in the SynMuv…
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Artikel Jurnal Teks lengkap
Origination of an X-Linked Testes Chimeric Gene by Illegitimate Recombination in Drosophila
The formation of chimeric gene structures provides important routes by which novel proteins and functions are introduced into genomes. Signatures of these events have been identified in organisms from wide phylogenic distributions. However, the ability to characterize the early phases of these…
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