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Ectopic expression of Aspergillus flavus uricase and URAT1 in therapeutic cells promotes intracellular degradation of uric acid in hyperuricemic mice
Uricase-based drugs excel at treating refractory hyperuricemia and tumor lysis syndrome by directly degrading uric acid but are limited by immunogenicity. Here, we engineered RAW264.7 macrophages with ectopic co-expression of Aspergillus flavus uricase and murine urate anion transporter 1 (URAT1)…
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Regional and temporal patterns of partisan polarization during the COVID-19 pandemic in the United States and Canada
During the COVID-19 pandemic, public health measures emerged as highly polarizing topics in online discourse, with debates intensifying around specific policy implementations and events. This study introduces a novel computational approach to measure subnational and event-driven variation in…
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CDR-Net: A computerized framework to detect Alzheimer’s diseases and mild cognitive impairment
Alzheimer’s disease (AD) and mild cognitive impairment (MCI) are two dementia-related brain illnesses that are prevalent among elders in the twenty-first century. MCI is treated as the initial stage of AD, and once the illness reaches the AD stage, there is no escape from certain death. The…
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Systemic iron availability differentially shapes tumor and brain iron handling in a sex-dependent manner in glioblastoma
Iron is essential for normal physiological function, yet dysregulation of iron metabolism is increasingly recognized as a hallmark of cancers such as glioblastoma (GBM). Recent clinical evidence suggests that systemic iron deficiency anemia (IDA) negatively impacts GBM outcomes in a sex-dependent…
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Differential regulation of p62-ubiquitin conjugates in neurons versus astrocytes during cellular stress
Sequestosome 1/p62 (hereafter referred to as p62) is a multifunctional protein that orchestrates various cellular stress response pathways including autophagy, proteasome-mediated degradation, antioxidant defense, nutrient sensing, and inflammatory signaling. Mutations in distinct functional…
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Single-cell RNA sequencing identifies microglial state changes associated with iTBS after ischemia–reperfusion injury
Understanding how to effectively treat neurological deficits after stroke remains difficult, as both the therapeutic targets and clinical outcomes are still uncertain. Although intermittent Theta burst stimulation (iTBS) has recently been shown to protect neural tissue in stroke-induced rats, its…
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La benchmarking large language models for extracting biobank-derived insights into health and disease
Biobank-scale datasets such as the UK Biobank have become foundational resources for advancing biomedical discovery. Yet the complexity and heterogeneity of these resources, spanning genomics, imaging, clinical records, and metadata, pose substantial barriers to access and interpretation. Large…
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Experiential learning to advocacy: A peer-led approach to safe medication disposal in pharmacy education
Introduction: Safe medication disposal is crucial for public health and environmental sustainability, yet public awareness remains limited. While educational campaigns exist, pharmacy students can serve as key advocates in promoting proper disposal practices. This study integrates experiential…
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Longitudinal brain health and neurological correlates of sexual strangulation in young adults: Study protocol for a prospective cohort study
Sexual strangulation (also referred to as choking during sex) has become increasingly prevalent among young adults and disproportionately affects females. Epidemiological studies indicate that more than half of college-aged women report a lifetime history of being strangled during sex, and it is…
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Assessing retention of pandemic capacities from COVID-19 in humanitarian settings: A cross-sectional retrospective study of health workers in Honduras, Syria, and South Sudan
The global health security landscape remains critically vulnerable to emerging pandemic threats. Humanitarian settings face particularly acute challenges in health workforce preparedness and response capabilities. Humanitarian settings have traditionally been left out of global health security and…
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Community-led standards for global wastewater-based infectious disease surveillance
The COVID-19 pandemic accelerated global adoption of wastewater and environmental surveillance (WES) and revealed its value as a complement to case-based infectious disease monitoring. However, practical scientific, ethical, and legal standards for public health implementation remain limited. To…
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Advancing aphasia psychological care in Ireland: A participatory study with people with aphasia and clinicians
Background: Aphasia increases the risk of mental health issues, yet psychological care for aphasia (APC) is not routinely available. Given the significant psychosocial impact, APC requires input from multiple disciplines and settings, and necessarily responds to a person’s needs, which shift over…
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Mapping sources of chronic disease-promoting products in retail environments: An analysis of co-location patterns of alcohol, tobacco, and fast-food retailers
Objective: High densities of alcohol, tobacco, and fast-food retailers each pose increased risk of behaviors that contribute to chronic diseases. However, retail density studies typically examine only one type of retailer at a time. This study examines co-location patterns of alcohol, tobacco, and…
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Assortativity in geometric and scale-free networks
The assortative behavior of a network is the tendency of similar (or dissimilar) nodes to connect to each other. This tendency can have an influence on various properties of the network, such as its robustness or the dynamics of spreading processes. In this paper, we study degree assortativity both…
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Design and acceptance assessment of a digital product passport for recycled and natural aggregate concrete elements
The construction sector accounts for a substantial share of global greenhouse gas emissions, making effective strategies for the reuse and recycling of building materials indispensable. However, relevant information may be lost over the relatively long use phase of buildings. Digital Product…
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Does electronic invoicing lead to stronger tax compliance? Evidence from China
This article investigates whether China’s fully digitalized electronic invoicing reform has improved tax compliance, using a staggered difference-in-differences approach. The results show that: (1) The e-invoicing reform has significantly improved firms’ effective tax rate by 0.91 percentage points…
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Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex
Heterogeneous Nuclear Ribonucleoprotein K (hnRNP K) is a limiting factor for prion propagation. However, little is known about the function of hnRNP K except that it is essential to cell survival. Here, we performed a synthetic-viability CRISPR ablation screen to identify epistatic interactors of…
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Predictors of severe strongyloidiasis and mortality in hospitalized patients from Southern Thailand
Background: Strongyloidiasis is a neglected tropical infection that can progress to life-threatening disease in immunocompromised hosts. However, predictors of severe disease and mortality remain incompletely defined, particularly in endemic regions. We aimed to identify clinical predictors of…
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Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in Rhinolophus and human cells
Asian Rhinolophus bats are considered the natural reservoirs of an ancestral SARS-CoV-2. However, the biology of SARS-CoV-2-related viruses in bat cells is not well understood. Here, we investigated the replication of an isolate of BANAL-236, the only bat-derived SARS-CoV-2 relative isolated to…
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Artikel Jurnal Teks lengkap
Cadherin-11 serves as a novel receptor for Fusobacterium nucleatum adhesin FadA to exacerbate pulmonary inflammation
Fusobacterium nucleatum, a periodontal pathogen, has been increasingly implicated in pulmonary diseases including chronic obstructive pulmonary disease (COPD). This study demonstrates that F. nucleatum adheres to and invades pulmonary epithelial cells in a dose-dependent manner, primarily mediated…
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