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Artikel Jurnal Teks lengkap
Unique Author Identification Number in Scientific Databases: A Suggestion
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Artikel Jurnal Teks lengkap
Statins in Patients with Chronic Kidney Disease: Evidence from Systematic Reviews and Randomized Clinical Trials
Good evidence supports the widespread use of statins for cardiovascular disease; there is less evidence for their use in kidney disease. The question is addressed by discussing published trials and systematic reviews.
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Artikel Jurnal Teks lengkap
The G Protein–Coupled Receptor Subset of the Chicken Genome
G protein–coupled receptors (GPCRs) are one of the largest families of proteins, and here we scan the recently sequenced chicken genome for GPCRs. We use a homology-based approach, utilizing comparisons with all human GPCRs, to detect and verify chicken GPCRs from translated genomic alignments and…
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Artikel Jurnal Teks lengkap
RNAi, DRD1, and Histone Methylation Actively Target Developmentally Important Non-CG DNA Methylation in Arabidopsis
Cytosine DNA methylation protects eukaryotic genomes by silencing transposons and harmful DNAs, but also regulates gene expression during normal development. Loss of CG methylation in the Arabidopsis thaliana met1 and ddm1 mutants causes varied and stochastic developmental defects that are often…
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A Perikinetochoric Ring Defined by MCAK and Aurora-B as a Novel Centromere Domain
Mitotic Centromere-Associated Kinesin (MCAK) is a member of the kinesin-13 subfamily of kinesin-related proteins. In mitosis, this microtubule-depolymerising kinesin seems to be implicated in chromosome segregation and in the correction of improper kinetochore-microtubule interactions, and its…
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Artikel Jurnal Teks lengkap
Why Do Hubs Tend to Be Essential in Protein Networks?
The protein–protein interaction (PPI) network has a small number of highly connected protein nodes (known as hubs) and many poorly connected nodes. Genome-wide studies show that deletion of a hub protein is more likely to be lethal than deletion of a non-hub protein, a phenomenon known as the…
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Artikel Jurnal Teks lengkap
Envelope Exchange for the Generation of Live-Attenuated Arenavirus Vaccines
Arenaviruses such as Lassa fever virus cause significant mortality in endemic areas and represent potential bioterrorist weapons. The occurrence of arenaviral hemorrhagic fevers is largely confined to Third World countries with a limited medical infrastructure, and therefore live-attenuated…
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Artikel Jurnal Teks lengkap
Mass Fatality Management following the South Asian Tsunami Disaster: Case Studies in Thailand, Indonesia, and Sri Lanka
Background: Following natural disasters, mismanagement of the dead has consequences for the psychological well-being of survivors. However, no technical guidelines currently exist for managing mass fatalities following large natural disasters. Existing methods of mass fatality management are not…
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Bacterial Symbionts May Prove a Double-Edged Sword for the Sharpshooter
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Artikel Jurnal Teks lengkap
Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch
C2 domains are well characterized as Ca2+/phospholipid-binding modules, but little is known about how they mediate protein–protein interactions. In neurons, a Munc13–1 C2A-domain/RIM zinc-finger domain (ZF) heterodimer couples synaptic vesicle priming to presynaptic plasticity. We now show that the…
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Artikel Jurnal Teks lengkap
The Genetic Basis of Thermal Reaction Norm Evolution in Lab and Natural Phage Populations
Two major goals of laboratory evolution experiments are to integrate from genotype to phenotype to fitness, and to understand the genetic basis of adaptation in natural populations. Here we demonstrate that both goals are possible by re-examining the outcome of a previous laboratory evolution…
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