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Artikel Jurnal Teks lengkap
Metabolic Complementarity and Genomics of the Dual Bacterial Symbiosis of Sharpshooters
Mutualistic intracellular symbiosis between bacteria and insects is a widespread phenomenon that has contributed to the global success of insects. The symbionts, by provisioning nutrients lacking from diets, allow various insects to occupy or dominate ecological niches that might otherwise be…
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Rational Prescribing in Primary Care (RaPP): A Cluster Randomized Trial of a Tailored Intervention
Background: A gap exists between evidence and practice regarding the management of cardiovascular risk factors. This gap could be narrowed if systematically developed clinical practice guidelines were effectively implemented in clinical practice. We evaluated the effects of a tailored intervention…
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Confronting the Neglected Problem of Snake Bite Envenoming: The Need for a Global Partnership
Envenoming resulting from snake bites is an important public health hazard in many regions of the world, yet public health authorities have given little attention to the problem.
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Rational Prescribing in Primary Care (RaPP): Economic Evaluation of an Intervention to Improve Professional Practice
Background: Interventions designed to narrow the gap between research findings and clinical practice may be effective, but also costly. Economic evaluations are necessary to judge whether such interventions are worth the effort. We have evaluated the economic effects of a tailored intervention to…
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Do Antidepressants Cure or Create Abnormal Brain States?
Moncrieff and Cohen argue that psychotropic drugs create abnormal states that may co-incidentally relieve symptoms of mental illness.
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Artikel Jurnal Teks lengkap
Apolipoprotein E and Coronary Disease: A Puzzling Paradox
Reilly and Rader discuss a new study in PLoS Medicine that shows an association between apoE levels and cardiovascular disease mortality.
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Artikel Jurnal Teks lengkap
Improving Prescribing Practices in Primary Care
Del Mar discusses the implications of the RaPP trial, a cluster RCT of a multi-component intervention to improve prescribing of antihypertensive and cholesterol-lowering drugs in primary care.
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Artikel Jurnal Teks lengkap
Sacred Cows and Sympathetic Squirrels: The Importance of Biological Diversity to Human Health
Dobson and colleagues describe how some host species act to reduce the risk of transmission of virulent zoonotic pathogens to humans.
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Artikel Jurnal Teks lengkap
Lessons from Our Patients: Development of a Warm Autopsy Program
Kaminski and colleagues discuss the lessons they have learned in establishing a warm autopsy program to advance research on idiopathic pulmonary fibrosis.
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Artikel Jurnal Teks lengkap
Deployment of Early Diagnosis and Mefloquine- Artesunate Treatment of Falciparum Malaria in Thailand: The Tak Malaria Initiative
Background: Early diagnosis and treatment with artesunate-mefloquine combination therapy (MAS) have reduced the transmission of falciparum malaria dramatically and halted the progression of mefloquine resistance in camps for displaced persons along the Thai-Burmese border, an area of low and…
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Artikel Jurnal Teks lengkap
Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom
Background: Snake venom is a potentially lethal and complex mixture of hundreds of functionally diverse proteins that are difficult to purify and hence difficult to characterize. These difficulties have inhibited the development of toxin-targeted therapy, and conventional antivenom is still…
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Implementation Research Is Needed to Achieve International Health Goals
Sanders and Haines discuss the "knowledge-implementation gap" and identify key obstacles to correcting the gap.
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Artikel Jurnal Teks lengkap
Does Random Treatment Assignment Cause Harm to Research Participants?
Background: Some argue that by precluding individualized treatment, randomized clinical trials (RCTs) provide substandard medical care, while others claim that participation in clinical research is associated with improved patient outcomes. However, there are few data to assess the impact of random…
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Acute-Phase Serum Amyloid A: An Inflammatory Adipokine and Potential Link between Obesity and Its Metabolic Complications
Background: Obesity is associated with low-grade chronic inflammation, and serum markers of inflammation are independent risk factors for cardiovascular disease (CVD). However, the molecular and cellular mechanisms that link obesity to chronic inflammation and CVD are poorly understood. Methods and…
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The Impact Factor Game
The PLoS Medicine editors argue that we need a better measure than the impact factor for assessing the biomedical literature.
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Artikel Jurnal Teks lengkap
Improving Imperfect Data from Health Management Information Systems in Africa Using Space–Time Geostatistics
Background: Reliable and timely information on disease-specific treatment burdens within a health system is critical for the planning and monitoring of service provision. Health management information systems (HMIS) exist to address this need at national scales across Africa but are failing to…
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Prioritizing Genomic Drug Targets in Pathogens: Application to Mycobacterium tuberculosis
We have developed a software program that weights and integrates specific properties on the genes in a pathogen so that they may be ranked as drug targets. We applied this software to produce three prioritized drug target lists for Mycobacterium tuberculosis, the causative agent of tuberculosis, a…
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A Community Resource Benchmarking Predictions of Peptide Binding to MHC-I Molecules
Recognition of peptides bound to major histocompatibility complex (MHC) class I molecules by T lymphocytes is an essential part of immune surveillance. Each MHC allele has a characteristic peptide binding preference, which can be captured in prediction algorithms, allowing for the rapid scan of…
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Artikel Jurnal Teks lengkap
How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory?
Immunological memory—the ability to “remember” previously encountered pathogens and respond faster upon re-exposure is a central feature of the immune response in vertebrates. The cross-reactive stimulation hypothesis for the maintenance of memory proposes that memory cells specific for a given…
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