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Moving Forward Moving Backward: Directional Sorting of Chemotactic Cells due to Size and Adhesion Differences
Differential movement of individual cells within tissues is an important yet poorly understood process in biological development. Here we present a computational study of cell sorting caused by a combination of cell adhesion and chemotaxis, where we assume that all cells respond equally to the…
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Exploring the Mycobacteriophage Metaproteome: Phage Genomics as an Educational Platform
Bacteriophages are the most abundant forms of life in the biosphere and carry genomes characterized by high genetic diversity and mosaic architectures. The complete sequences of 30 mycobacteriophage genomes show them collectively to encode 101 tRNAs, three tmRNAs, and 3,357 proteins belonging to…
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Allele-Specific KRT1 Expression Is a Complex Trait
The differential expression of alleles occurs commonly in humans and is likely an important genetic factor underlying heritable differences in phenotypic traits. Understanding the molecular basis of allelic expression differences is thus an important challenge. Although many genes have been shown…
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Genetic Screens for Mutations Affecting Development of Xenopus tropicalis
We present here the results of forward and reverse genetic screens for chemically-induced mutations in Xenopus tropicalis. In our forward genetic screen, we have uncovered 77 candidate phenotypes in diverse organogenesis and differentiation processes. Using a gynogenetic screen design, which…
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Effect of Folic Acid and Betaine Supplementation on Flow-Mediated Dilation: A Randomized, Controlled Study in Healthy Volunteers
Objectives: We investigated whether lowering of fasting homocysteine concentrations, either with folic acid or with betaine supplementation, differentially affects vascular function, a surrogate marker for risk of cardiovascular disease, in healthy volunteers. As yet, it remains uncertain whether a…
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CCR5 Is Essential for NK Cell Trafficking and Host Survival following Toxoplasma gondii Infection
The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquired response. We analyzed the host response of…
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Anopheles gambiae Immune Responses to Human and Rodent Plasmodium Parasite Species
Transmission of malaria is dependent on the successful completion of the Plasmodium lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue, where most parasites are killed by the mosquito's immune system. In the present study, DNA microarray analyses have been used…
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Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia
Influenza A virus (IAV) is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. Recently, we demonstrated, using an in vitro approach, that the pattern recognition Toll-like receptor (TLR)3 plays a key role in the immune…
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Prevalence of Local Immune Response against Oral Infection in a Drosophila / Pseudomonas Infection Model
Pathogens have developed multiple strategies that allow them to exploit host resources and resist the immune response. To study how Drosophila flies deal with infectious diseases in a natural context, we investigated the interactions between Drosophila and a newly identified entomopathogen…
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Manslaughter by Fake Artesunate in Asia—Will Africa Be Next?
Fake artesunate could compromise the hope that artemisinin-based combination therapy offers for malaria control in Africa and Asia.
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Artikel Jurnal Teks lengkap
Environmental Coupling of Selection and Heritability Limits Evolution
There has recently been great interest in applying theoretical quantitative genetic models to empirical studies of evolution in wild populations. However, while classical models assume environmental constancy, most natural populations exist in variable environments. Here, we applied a novel…
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Instituting Change
MIT helps its researchers comply with the NIH policy on submitting published research to PubMed Central.
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All for All
A review of Michael Ashburner's book Won for All: How the Drosophila Genome Was Sequenced.
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Leveraging the Knowledge of Our Peers: Online Communities Hold the Promise to Enhance Scientific Research
SIPHS is a tool that leverages scientific resources online in a different fashion: rather than searching for online documents, users search for community members with a particular knowledge set.
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DNA Detection Using Recombination Proteins
DNA amplification is essential to most nucleic acid testing strategies, but established techniques require sophisticated equipment or complex experimental procedures, and their uptake outside specialised laboratories has been limited. Our novel approach, recombinase polymerase amplification (RPA)…
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Viruses' Life History: Towards a Mechanistic Basis of a Trade-Off between Survival and Reproduction among Phages
Life history theory accounts for variations in many traits involved in the reproduction and survival of living organisms, by determining the constraints leading to trade-offs among these different traits. The main life history traits of phages—viruses that infect bacteria—are the multiplication…
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Restoring Nature's Backbone
Is it feasible to introduce contemporary species to fulfill the ecological role of species that went extinct thousands of years ago (rewilding) and can it work as an effective conservation strategy?
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