3.382 hasil
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Artikel Jurnal Teks lengkap
DNA Repair: Dynamic Defenders against Cancer and Aging
This primer provides an introduction to mechanisms involved in DNA repair, specifically nucleotide excision repair, and their relevance to disease.
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Artikel Jurnal Teks lengkap
A New Twist on an Animal Model Reveals Environmental Constraints on Selection
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Artikel Jurnal Teks lengkap
Characterizing a Key Player in Micro, but Not Small, RNA Interference
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Artikel Jurnal Teks lengkap
The Roulette Wheel: An Aid to Informed Decision Making
The authors outline a new visual tool that can help patients assess the benefits and risks of different treatments.
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Artikel Jurnal Teks lengkap
Suicide Rates and Antidepressant Prescribing: A Casual or Causal Relationship?
Baune and Hay discuss the strengths and limitations of an ecological study that found an inverse correlation between suicide rates and fluoxetine prescriptions.
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Artikel Jurnal Teks lengkap
Labor-Associated Gene Expression in the Human Uterine Fundus, Lower Segment, and Cervix
Background: Preterm labor, failure to progress, and postpartum hemorrhage are the common causes of maternal and neonatal mortality or morbidity. All result from defects in the complex mechanisms controlling labor, which coordinate changes in the uterine fundus, lower segment, and cervix. We aimed…
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Artikel Jurnal Teks lengkap
The National Security Implications of HIV/AIDS
Feldbaum and colleagues look at evidence on the links between HIV and national security, and evaluate the risks and benefits of addressing HIV/AIDS as a national security issue.
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Artikel Jurnal Teks lengkap
Modeling of the Temporal Patterns of Fluoxetine Prescriptions and Suicide Rates in the United States
Background: To study the potential association of antidepressant use and suicide at a population level, we analyzed the associations between suicide rates and dispensing of the prototypic SSRI antidepressant fluoxetine in the United States during the period 1960–2002. Methods and Findings: Sources…
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Artikel Jurnal Teks lengkap
Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
Background: The autoimmune regulator (AIRE) gene influences thymic self-tolerance induction. In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM 240300), recessive AIRE mutations lead to autoimmunity targetting endocrine and other epithelial tissues, although chronic candidiasis usually…
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Artikel Jurnal Teks lengkap
Anti-Interferon Auto-Antibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
Levin discusses a new study, by Meager and colleagues, which identified a novel target of the disordered immune response in patients with APS-1.
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Artikel Jurnal Teks lengkap
Insights into the Physiology of Childbirth Using Transcriptomics
Romero and colleagues discuss a study in PLoS Medicine that used microarrays to determine labor-associated gene expression profiles in the human uterus.
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Artikel Jurnal Teks lengkap
Dynamic Encoding of Natural Luminance Sequences by LGN Bursts
In the lateral geniculate nucleus (LGN) of the thalamus, visual stimulation produces two distinct types of responses known as tonic and burst. Due to the dynamics of the T-type Ca2+ channels involved in burst generation, the type of response evoked by a particular stimulus depends on the resting…
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Artikel Jurnal Teks lengkap
Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54
RNA interference is triggered by double-stranded RNA that is processed into small interfering RNAs (siRNAs) by Dicer enzyme. Endogenously, RNA interference triggers are created from small noncoding RNAs called microRNAs (miRNAs). RNA-induced silencing complexes (RISC) in human cells can be…
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Artikel Jurnal Teks lengkap
Ultra-Fast Evaluation of Protein Energies Directly from Sequence
The structure, function, stability, and many other properties of a protein in a fixed environment are fully specified by its sequence, but in a manner that is difficult to discern. We present a general approach for rapidly mapping sequences directly to their energies on a pre-specified rigid…
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Artikel Jurnal Teks lengkap
Integrated Assessment and Prediction of Transcription Factor Binding
Systematic chromatin immunoprecipitation (chIP-chip) experiments have become a central technique for mapping transcriptional interactions in model organisms and humans. However, measurement of chromatin binding does not necessarily imply regulation, and binding may be difficult to detect if it is…
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Artikel Jurnal Teks lengkap
On Modeling HIV and T Cells In Vivo: Assessing Causal Estimators in Vaccine Trials
The first efficacy trials—named STEP—of a T cell vaccine against HIV/AIDS began in 2004. The unprecedented structure of these trials raised new modeling and statistical challenges. Is it plausible that memory T cells, as opposed to antibodies, can actually prevent infection? If they fail at…
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Artikel Jurnal Teks lengkap
Inference of Disease-Related Molecular Logic from Systems-Based Microarray Analysis
Computational analysis of gene expression data from microarrays has been useful for medical diagnosis and prognosis. The ability to analyze such data at the level of biological modules, rather than individual genes, has been recognized as important for improving our understanding of disease-related…
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Artikel Jurnal Teks lengkap
Nuclear mRNA Degradation Pathway(s) Are Implicated in Xist Regulation and X Chromosome Inactivation
A critical step in X-chromosome inactivation (XCI), which results in the dosage compensation of X-linked gene expression in mammals, is the coating of the presumptive inactive X chromosome by the large noncoding Xist RNA, which then leads to the recruitment of other factors essential for the…
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Artikel Jurnal Teks lengkap
Schistosoma mansoni TGF-β Receptor II: Role in Host Ligand-Induced Regulation of a Schistosome Target Gene
Members of transforming growth factor-beta (TGF-β) superfamily play pivotal roles in development in multicellular organisms. We report the functional characterization of the Schistosoma mansoni type II receptor (SmTβRII). Mining of the S. mansoni expressed sequence tag (EST) database identified an…
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Artikel Jurnal Teks lengkap
Impact of Bacterial Genetics on the Transmission of Isoniazid-Resistant Mycobacterium tuberculosis
Understanding the ecology of drug-resistant pathogens is essential for devising rational programs to preserve the effective lifespan of antimicrobial agents and to abrogate epidemics of drug-resistant organisms. Mathematical models predict that strain fitness is an important determinant of…
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