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Spatio–temporal modelling of in vitro influenza A virus infection: The impact of defective interfering particles on the type I interferon response
Defective interfering particles (DIPs) are incomplete viral genomes that modulate infection by competing with wild–type viruses and activating the innate immune response. Activation of the immune response leads to the production of cytokines and chemokines, including type I interferon (IFN), which…
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Assessing the acceptability of photographs and medical illustrations in Buruli ulcer health communication among health providers, community volunteers and community members in endemic districts of Ghana
Background: The control of Buruli ulcer (BU) relies on early case detection to improve disease outcomes. While lesion photographs are currently used in health communication materials, they have many drawbacks. Medical illustrations, though proven effective in many contexts, remain unutilised for…
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Phase-field modeling of border cell cluster migration in Drosophila
Collective cell migration is a fundamental biological process that drives events such as embryonic development, wound healing, and cancer metastasis. In this study, we develop a biophysically informed phase-field model to investigate the collective migration of the border cell cluster in the…
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Modeling neonatal immune response to B. pertussis identifies early B cell activation and differentiation
Pertussis is typically more severe in neonates and young infants, with fulminant forms possibly linked to age-specific systemic immune responses. However, the early events that shape the development of the immune response in neonates are poorly understood, mainly due to limited sample access and…
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CiliaKB: A comprehensive knowledge base for cilia-associated genes
Cilia dysfunction is implicated in a range of disorders. Here, we present CiliaKB, a manually curated knowledge base that serves as a one-stop platform for researchers to rapidly access mechanistic data and mine for translational clues about cilia. Cilia dysfunction is implicated in a range of…
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Macroscopic and histological analyses of cremated remains from the Imperial Roman necropolis of La Cona (1 st cent. BCE-1 st cent. CE, Teramo, Italy)
Cremation was one of the most widespread funerary practices between the Bronze Age and Late Antiquity in Mediterranean societies. Despite its archaeological relevance, the analysis of cremated human remains has long been limited by extensive thermal alteration, which hampers the reconstruction of…
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Association between physical activity and mental health (emotional and peer problems) in children and adolescents, a national follow-up study
Background: While extensive evidence demonstrates the beneficial effects of physical activity on adult mental health, research examining these relationships in childhood remains limited and inconsistent. This study investigated the prospective associations between objectively measured physical…
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Unburnable carbon in the rapidly warming Arctic: Mapping spatial relationships among oil and gas development, ecologically sensitive areas and Indigenous Peoples’ lands
As global temperatures rise due to carbon emissions from fossil fuels, it is estimated that around 60% of oil and gas reserves —termed 'unburnable carbon'—must remain underground to meet international climate targets. The Arctic, warming nearly four times faster than the global average, is a…
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Nicotine dependence among critically ill COVID-19 patients: A population-based cohort study
Nicotine dependence is associated with lower life expectancy and patients who use nicotine are at an increased risk of diseases of the respiratory system. Data on the prognostic impact of nicotine dependence in COVID-19 is inconclusive. We used publicly available, statewide, and deidentified…
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The effects of temperature on nestling growth in a songbird depend on developmental constraints
Climate change can adversely impact animals, especially those that cannot independently thermoregulate or avoid exposure to temperature variation. Altricial bird nestlings may be particularly vulnerable to temperature variation, with cold, hot, and variable temperatures leading to reduced nestling…
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When merchandise crowds the aisle and carts crowd the shopper: Joint effects on sales
This research examines how fixture-induced spatial crowding suppresses in-store purchasing and how shopping aids—particularly carts—amplify this effect by expanding users’ peripersonal space and diminishing perceived control. In doing so, it addresses a central trade-off in retail design: while…
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Stomatal responses of differently CO 2 -acclimated plants to natural and experimental CO 2 gradients
Stomata, the microscopic pores in the epidermis of plant leaves, facilitate gas exchange between the leaf interior and the external environment and thus play a pivotal role in the global carbon, water, and energy cycles. Their development and function are influenced by atmospheric CO₂ levels…
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Impact of yoga on cardiometabolic health in adults with overweight or obesity: A systematic review and meta-analysis of randomized controlled trials
This systematic review examined the effects of yoga interventions on various cardiometabolic health outcomes in adults with overweight or obesity. Seven major electronic databases and two clinical trial databases were searched from inception to November 2024. The search strategy combined keywords…
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Silicone toothbrushes: A scoping review of an underutilized tool in global oral health
Oral diseases are the most prevalent non-communicable diseases worldwide, affecting 3.5 billion people, with a disproportionate impact on those living in low- and middle-income countries. Despite being largely preventable through proper oral hygiene, current oral health promotion strategies rely…
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The influence of extreme rainfall on crime: Spatiotemporal dynamics in Hunan Province, China
The influence of extreme weather events on social stability is increasingly acknowledged as a critical and pressing concern. Utilizing data on the criminal offenses, extreme climate conditions, and socio-economic indicators from counties and cities in Hunan Province for the period 2014–2018, this…
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Casting a long shadow: Exploring the link between childhood maltreatment and cancer in adulthood
Childhood adversities, including physical abuse, sexual abuse, and exposure to parental domestic violence (PDV), have been linked to negative health outcomes in adulthood, yet their specific association with cancer in older Canadians remains understudied. The current study investigated the…
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Changes in anthropometric indices, lifestyle patterns, and mental stress with ramadan intermittent fasting among healthy students: A prospective cohort study
Background: The association between Ramadan Intermittent Fasting (RIF) and metabolic diseases has been studied. However, there remains a significant gap in the research regarding the changes in anthropometric indices related to body weight during RIF, as these have not been extensively…
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In-hospital outcomes and hospital charges after robotic-assisted versus conventional total knee arthroplasty: A 2016–2022 Nationwide Inpatient Sample study
Background: Robotic-assisted total knee arthroplasty has been adopted to enhance surgical precision, yet contemporary national evidence on clinical and economic outcomes remains limited. Objective: To compare in-hospital complications, length of stay, and hospital charges between robotic-assisted…
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