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Artikel Jurnal Teks lengkap
Packaging Health Services When Resources Are Limited: The Example of a Cervical Cancer Screening Visit
Background: Increasing evidence supporting the value of screening women for cervical cancer once in their lifetime, coupled with mounting interest in scaling up successful screening demonstration projects, present challenges to public health decision makers seeking to take full advantage of the…
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Hypertension and Maternal–Fetal Conflict during Placental Malaria
Background: Malaria and hypertension are major causes of maternal mortality in tropical countries, especially during first pregnancies, but evidence for a relationship between these syndromes is contradictory. Methods and Findings: In a cross-sectional survey of Tanzanian parturients, the rate of…
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Artikel Jurnal Teks lengkap
The Mechanistic Classification of Addictive Drugs
The authors review recent research on the molecular mechanisms of addiction and propose a new classification for addictive drugs.
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Artikel Jurnal Teks lengkap
Dominance of HIV-1 Subtype CRF01_AE in Sexually Acquired Cases Leads to a New Epidemic in Yunnan Province of China
Background: Dating back to the first epidemic among injection drug users in 1989, the Yunnan province has had the highest number of human immunodeficiency virus type 1 (HIV-1) infections in China. However, the molecular epidemiology of HIV-1 in Yunnan has not been fully characterized. Methods and…
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Artikel Jurnal Teks lengkap
Bushes in the Tree of Life
A discussion of how homoplasy (the frequency of independently evolved characters) and the spacing of cladogenetic events limit our ability to reconstruct the tree of life using existing phylogenetic methods.
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Artikel Jurnal Teks lengkap
Shellfish Dredging Pushes a Flexible Avian Top Predator out of a Marine Protected Area
There is a widespread concern about the direct and indirect effects of industrial fisheries; this concern is particularly pertinent for so-called “marine protected areas” (MPAs), which should be safeguarded by national and international law. The intertidal flats of the Dutch Wadden Sea are a State…
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Artikel Jurnal Teks lengkap
A Maternal–Offspring Coadaptation Theory for the Evolution of Genomic Imprinting
Imprinted genes are expressed either from the maternally or paternally inherited copy only, and they play a key role in regulating complex biological processes, including offspring development and mother–offspring interactions. There are several competing theories attempting to explain the…
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Artikel Jurnal Teks lengkap
BioGeomancer: Automated Georeferencing to Map the World's Biodiversity Data
The BioGeomancer Project provides a toolkit to georeference data and specimens collected for natural history collections, a crucial task if the potential of these specimens is to be fully realized.
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The Genome of Deep-Sea Vent Chemolithoautotroph Thiomicrospira crunogena XCL-2
Presented here is the complete genome sequence of Thiomicrospira crunogena XCL-2, representative of ubiquitous chemolithoautotrophic sulfur-oxidizing bacteria isolated from deep-sea hydrothermal vents. This gammaproteobacterium has a single chromosome (2,427,734 base pairs), and its genome…
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Correction: Morphological Evolution Is Accelerated among Island Mammals
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Artikel Jurnal Teks lengkap
Correction: Preserving Genome Integrity: The DdrA Protein of Deinococcus radiodurans R1
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Artikel Jurnal Teks lengkap
Two or Four Bristles: Functional Evolution of an Enhancer of scute in Drosophilidae
Changes in cis-regulatory sequences are proposed to underlie much of morphological evolution. Yet, little is known about how such modifications translate into phenotypic differences. To address this problem, we focus on the dorsocentral bristles of Drosophilidae. In Drosophila melanogaster…
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Artikel Jurnal Teks lengkap
A Marriage of Old and New: Chemostats and Microarrays Identify a New Model System for Ammonium Toxicity
Toxicity is related to an organism's ability to rid itself of the offending molecules. This primer provides insights into how this can be monitored by highlighting the case of ammonium toxicity.
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Artikel Jurnal Teks lengkap
Optimal Noise Filtering in the Chemotactic Response of Escherichia coli
Information-carrying signals in the real world are often obscured by noise. A challenge for any system is to filter the signal from the corrupting noise. This task is particularly acute for the signal transduction network that mediates bacterial chemotaxis, because the signals are subtle, the noise…
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3D Complex: A Structural Classification of Protein Complexes
Most of the proteins in a cell assemble into complexes to carry out their function. It is therefore crucial to understand the physicochemical properties as well as the evolution of interactions between proteins. The Protein Data Bank represents an important source of information for such studies…
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Artikel Jurnal Teks lengkap
An Integrative Genomic Approach to Uncover Molecular Mechanisms of Prokaryotic Traits
With mounting availability of genomic and phenotypic databases, data integration and mining become increasingly challenging. While efforts have been put forward to analyze prokaryotic phenotypes, current computational technologies either lack high throughput capacity for genomic scale analysis, or…
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Defining Synphenotype Groups in Xenopus tropicalis by Use of Antisense Morpholino Oligonucleotides
To identify novel genes involved in early development, and as proof-of-principle of a large-scale reverse genetics approach in a vertebrate embryo, we have carried out an antisense morpholino oligonucleotide (MO) screen in Xenopus tropicalis, in the course of which we have targeted 202 genes…
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Artikel Jurnal Teks lengkap
Four Linked Genes Participate in Controlling Sporulation Efficiency in Budding Yeast
Quantitative traits are conditioned by several genetic determinants. Since such genes influence many important complex traits in various organisms, the identification of quantitative trait loci (QTLs) is of major interest, but still encounters serious difficulties. We detected four linked genes…
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