417.678 hasil
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Maternal serum progesterone and BMI are associated with neonatal sex ratios following single frozen embryo transfer
Background: The biological mechanisms behind sex ratio variation in assisted reproductive technologies (ART) are not well understood. This study investigated whether maternal serum progesterone (PRG) and body mass index (BMI) are related to neonatal sex after frozen–thawed embryo transfer (FET)…
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PLoS Neglected Tropical Diseases Issue Image | Vol. 20(3) April 2026
: Field evaluation of a portable artificial intelligence–powered digital pathology (AI DP) platform for the detection of soil transmitted helminths and intestinal schistosomiasis in a zero infrastructure rural setting. Local technicians compare results from AI assisted slide scanners with…
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PLOS Sustainability and Transformation Issue Image | Vol. 5(3) April 2026
: Understanding why certain values of nature become legitimate and institutionalised while others remain marginal is central to advancing sustainability transformations. This paper from Ishihara & Pascual develops a conceptual framework that integrates the notions of symbolic power and socially…
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Rural-to-urban migrant worker mobility shaped measles epidemics in China
Despite sustained high routine childhood vaccination coverage, measles outbreaks have persisted across Provincial-Level Administrative Divisions (PLADs) in China. Epidemiological evidence suggests that migrant workers substantially contribute to these outbreaks. In this study, we investigated the…
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Research on hybrid cloud resource scheduling optimization algorithm based on EMPA-ASA
Hybrid–cloud scheduling must balance cost, performance, and reliability; yet existing approaches often suffer from burdensome parameter tuning, a limited set of optimized QoS indicators, and high computational overhead. To address these issues, we propose an EMPA–ASA–based hybrid–cloud resource…
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Exploring the preferences of multiple stakeholder groups for family involvement in early intervention services for psychosis: A cross-sectional mixed-methods study
There is consistent evidence that family involvement leads to improved outcomes in psychosis. However, less is known about various stakeholders’ (patients, families, clinicians) preferences. This study aimed to understand stakeholders’ views about involving families in care for youth experiencing…
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Mental health disorders, and associated factors among children aged 6–17 years living in Mahama refugee camp in Rwanda
Children living in refugee camps are negatively affected by adverse mental health outcomes due to traumatic experiences and living conditions such as food insecurity. However, the mental health disorders of children living in refugee camps of Rwanda have not yet been empirically reported. This…
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HSV ICP27 hijacks host splicing factor SRSF3 to regulate pre-mRNA splicing and export for viral gene expression and immune evasion
HSV ICP27, a multifunctional essential immediate early (IE) viral protein, regulates both viral and host pre-mRNA processing in a gene/sequence-specific manner. Using viral mutagenesis studies, we investigated the mechanisms underlying ICP27-mediated co-transcriptional splicing inhibition. We…
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Structural insights into subtype-specific agonist recognition by sphingosine-1-phosphate receptors
Sphingosine-1-phosphate (S1P), a key metabolite of sphingolipids, plays crucial roles in a wide range of physiological and pathological processes. S1P primarily exerts its functions by binding to G protein-coupled sphingosine-1-phosphate receptors (S1PRs), which comprise five subtypes (S1PR1-5) in…
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Comparison of serum vitamin D level and vitamin D receptor gene FokI polymorphism in leprosy patients with and without trophic ulcers: A case-control study
Background: Alterations in the vitamin D axis have been implicated in chronic wounds, but their role in leprosy-related trophic ulcers (TU) is unclear. This study compared serum vitamin D levels and VDR FokI (rs2228570) polymorphism between leprosy patients with and without TU, assessed their…
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Cytotoxic Vδ2+ T cell subsets expand in response to malaria in human tonsil and spleen organoids
Vaccine effectiveness against malaria is dramatically reduced in malaria-exposed compared to malaria-naïve populations, potentially due to altered immune responses in secondary lymphoid organs following repeated infection. Newly developed human tonsil and spleen organoids, which replicate key…
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Characterization of a C9orf72 Knockout Danio rerio model for ALS and cross-species validation of potential therapeutics screened in Caenorhabditis elegans
Intronic hexanucleotide repeat expansions in the C9orf72 gene represent the most common genetic cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. This expansion decreases C9orf72 expression in affected patients, indicating that loss of C9orf72…
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Protocol for a scoping review on information and communication technologies (ICTs) in community practice
Introduction: There is a growing literature connecting information and communication technologies (ICTs) to community-based practices including community organizing, community development, and participatory planning. Over a decade ago, the American Academy of Social Work and Social Welfare launched…
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Exploring barriers and enablers to diabetes self-care practice in Ethiopia, 2025: A qualitative systematic review
Introduction: Diabetes mellitus is a growing public health concern in Ethiopia, with increasing prevalence and a high proportion of undiagnosed cases. Effective self-care is crucial for managing diabetes; however, many patients face challenges ranging from personal beliefs to systemic and…
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Evolutionary game analysis of emergency medical supply production capacity reserves in nonprofit organizations: A theoretical perspective
Since the 21st century, global public health emergencies have occurred frequently, posing severe threats to the economic development and social stability of countries worldwide. Against this backdrop, emergency medical supply reserves are particularly crucial—especially the production capacity…
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Navigating international academic collaboration: The Arabic translation and cultural adaptation of the Quality Maternal and Newborn Care Framework index
Background: The Quality Maternal and Newborn Care Framework index (QMNCFi) is a validated English-language instrument developed to assess women’s experiences during pregnancy, childbirth, and the postnatal period. These experiences include respect, dignity, communication, continuity of care, and…
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When income buffers extreme weather: Impacts on women’s mental health in informal settlements
Climate change threatens mental health, especially for the more than one billion residents in informal settlements worldwide. Utilizing longitudinal data collected from women in households in two of Nairobi’s largest informal settlements, we examined the mental health impacts of extreme weather and…
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Prevalence and factors associated with obesity in Rwanda: Evidence from the 2022 NCD STEPS Survey
Obesity is an emerging public health concern in Rwanda, yet nationally representative data on its associated factors remain limited. This study analyzes recent survey data to assess the prevalence of obesity and explore associated demographic, behavioral, and metabolic characteristics. The study…
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In foreign pastures: Livestock mobility at Hazor and the permeability of Iron Age geopolitical borders in the Southern Levant
Southern Levantine societies during the Iron Age II (10th–8th centuries BCE) witnessed the formation of competing territorial polities and urban revival following a period of settlement ruralization and dwindling regional exchange economies associated with the collapse of Late Bronze Age Canaanite…
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Time to incidence of tuberculosis and its predictors among adult HIV/AIDS patients who initiated ART by the Universal Test and Treat approach in Silte Zone, Ethiopia, 2023
Tuberculosis (TB) remains a leading cause of morbidity and mortality among people living with HIV. TB/HIV co-infection continues to challenge global TB control efforts. This study aimed to estimate the incidence and identify predictors of TB among adult HIV-infected patients who initiated…
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