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Artikel Jurnal Teks lengkap
Correction: Is the Current Management of Severe Sepsis and Septic Shock Really Evidence Based?
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Artikel Jurnal Teks lengkap
Correction: Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection
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Artikel Jurnal Teks lengkap
Drug Development Papers in PLoS Medicine : How We Try to Spot a Winner
Deciding which drug development papers are appropriate for publication in a general medical journal is not simple; here, editorial board member, Sanjeev Krishna, and the editors discuss their strategy.
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Artikel Jurnal Teks lengkap
An HIV Feedback Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer
Animal viruses (e.g., lentiviruses and herpesviruses) use transcriptional positive feedback (i.e., transactivation) to regulate their gene expression. But positive-feedback circuits are inherently unstable when turned off, which presents a particular dilemma for latent viruses that lack…
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Artikel Jurnal Teks lengkap
Rate of Evolution in Brain-Expressed Genes in Humans and Other Primates
Brain-expressed genes are known to evolve slowly in mammals. Nevertheless, since brains of higher primates have evolved rapidly, one might expect acceleration in DNA sequence evolution in their brain-expressed genes. In this study, we carried out full-length cDNA sequencing on the brain…
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Artikel Jurnal Teks lengkap
Biosynthesis of Selenocysteine on Its tRNA in Eukaryotes
Selenocysteine (Sec) is cotranslationally inserted into protein in response to UGA codons and is the 21st amino acid in the genetic code. However, the means by which Sec is synthesized in eukaryotes is not known. Herein, comparative genomics and experimental analyses revealed that the mammalian Sec…
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Artikel Jurnal Teks lengkap
Alternative 3′ Pre-mRNA Processing in Saccharomyces cerevisiae Is Modulated by Nab4/Hrp1 In Vivo
The Saccharomyces cerevisiae RNA-binding protein Nab4/Hrp1 is a component of the cleavage factor complex required for 3′ pre-mRNA processing. Although the precise role of Nab4/Hrp1 remains unclear, it has been implicated in correct positioning of the cleavage site in vitro. Here, we show that…
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Artikel Jurnal Teks lengkap
Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors
The multidrug exporter AcrB is the inner membrane component of the AcrAB-TolC drug efflux system in Escherichia coli and is responsible for the resistance of this organism to a wide range of drugs. Here we describe the crystal structure of the trimeric AcrB in complex with a designed ankyrin-repeat…
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Artikel Jurnal Teks lengkap
Towards Alignment Independent Quantitative Assessment of Homology Detection
Identification of homologous proteins provides a basis for protein annotation. Sequence alignment tools reliably identify homologs sharing high sequence similarity. However, identification of homologs that share low sequence similarity remains a challenge. Lowering the cutoff value could enable the…
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Artikel Jurnal Teks lengkap
Transcriptional Changes Common to Human Cocaine, Cannabis and Phencyclidine Abuse
A major goal of drug abuse research is to identify and understand drug-induced changes in brain function that are common to many or all drugs of abuse. As these may underlie drug dependence and addiction, the purpose of the present study was to examine if different drugs of abuse effect changes in…
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Artikel Jurnal Teks lengkap
Cooperation between Engulfment Receptors: The Case of ABCA1 and MEGF10
The engulfment of dying cells is a specialized form of phagocytosis that is extremely conserved across evolution. In the worm, it is genetically controlled by two parallel pathways, which are only partially reconstituted in mammals. We focused on the recapitulation of the CED-1 defined pathway in…
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Artikel Jurnal Teks lengkap
Acceptance of Anti-Retroviral Therapy among Patients Infected with HIV and Tuberculosis in Rural Malawi Is Low and Associated with Cost of Transport
Background: A study was conducted among newly registered HIV-positive tuberculosis (TB) patients systematically offered anti-retroviral treatment (ART) in a district hospital in rural Malawi in order to a) determine the acceptance of ART b) conduct a geographic mapping of those placed on ART and c)…
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Artikel Jurnal Teks lengkap
Shaping Leg Muscles in Drosophila : Role of ladybird, a Conserved Regulator of Appendicular Myogenesis
Legs are locomotor appendages used by a variety of evolutionarily distant vertebrates and invertebrates. The primary biological leg function, locomotion, requires the formation of a specialised appendicular musculature. Here we report evidence that ladybird, an orthologue of the Lbx1 gene…
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Artikel Jurnal Teks lengkap
Natural Variation in Partial Resistance to Pseudomonas syringae Is Controlled by Two Major QTLs in Arabidopsis thaliana
Background: Low-level, partial resistance is pre-eminent in natural populations, however, the mechanisms underlying this form of resistance are still poorly understood. Methodology/Principal Findings: In the present study, we used the model pathosystem Pseudomonas syringae pv. tomato DC3000 (Pst) -…
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Artikel Jurnal Teks lengkap
IL-7 Up-Regulates TNF-α-Dependent Osteoclastogenesis in Patients Affected by Solid Tumor
Background: Interleukin-7 (IL-7) is a potent regulator of lymphocyte development, which has also significant effects on bone; in fact it is a potent osteoclastogenic factor. Some human solid tumors produce high IL-7 levels, suggesting a potential IL-7 role on tumor development and progression…
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Artikel Jurnal Teks lengkap
Heterozygote Advantage for Fecundity
Heterozygote advantage, or overdominance, remains a popular and persuasive explanation for the maintenance of genetic variation in natural populations in the face of selection. However, despite being first proposed more than 80 years ago, there remain few examples that fit the criteria for…
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Artikel Jurnal Teks lengkap
Docking of Secretory Vesicles Is Syntaxin Dependent
Secretory vesicles dock at the plasma membrane before they undergo fusion. Molecular docking mechanisms are poorly defined but believed to be independent of SNARE proteins. Here, we challenged this hypothesis by acute deletion of the target SNARE, syntaxin, in vertebrate neurons and neuroendocrine…
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Artikel Jurnal Teks lengkap
Gender Differences in Publication Output: Towards an Unbiased Metric of Research Performance
We examined the publication records of a cohort of 168 life scientists in the field of ecology and evolutionary biology to assess gender differences in research performance. Clear discrepancies in publication rate between men and women appear very early in their careers and this has consequences…
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