100 hasil untuk "Li-Yu Lin"
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Berberine Protects against Palmitate-Induced Endothelial Dysfunction: Involvements of Upregulation of AMPK and eNOS and Downregulation of NOX4
Endothelial dysfunction is a critical factor during the initiation of cardiovascular complications in diabetes. Berberine can ameliorate endothelial dysfunction induced by diabetes. However, the underlying mechanisms remain unclear. The aim of this study was to investigate the protective effect and…
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SMAD4 is a potential prognostic marker in human breast carcinomas
SMAD4 is a downstream mediator of transforming growth factor beta. While its tumor suppressor function has been investigated as a prognostic biomarker in several human malignancies, its role as a prognostic marker in breast carcinoma is still undefined. We investigated SMAD4 expression in breast…
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Earlier flowering did not alter pollen limitation in an early flowering shrub under short-term experimental warming
In animal pollinated plants, phenological shifts caused by climate change may have important ecological consequences. However, no empirical evidence exists at present on the consequences that flowering phenology shifts have on the strength of pollen limitation under experimental warming. Here, we…
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High efficient isolation and systematic identification of human adipose-derived mesenchymal stem cells
BACKGROUND: Developing efficient methods to isolate and identify human adipose-derived mesenchymal stem cells (hADSCs) remains to be one of the major challenges in tissue engineering. METHODS: We demonstrate here a method by isolating hADSCs from abdominal subcutaneous adipose tissue harvested…
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Indocyanine Green Fluorescence Imaging for Evaluation of Uterine Blood Flow in Cynomolgus Macaque
Background: Uterine blood flow is an important factor in uterine viability, but the number of blood vessels required to maintain viability is uncertain. In this study, indocyanine green (ICG) fluorescence imaging was used to examine uterine hemodynamics and vessels associated with uterine blood…
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Comparison of OA-2000 and IOL Master 500 using in cataract patients with high myopia
This study was designed to compare optical biometry measurements and predicted refraction in cataract patients with high myopia [axial length (AL) ≥26 mm] using OA-2000 and IOL Master 500. Ocular biometry measurements were performed using both biometers before surgery. Uneventful cataract surgery…
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Effects of acupotomy therapy on macrophage polarization and inhibition of synovial inflammation in rabbits with knee osteoarthritis based on the Notch1/Jagged1/Hes1 signaling pathway
ObjectiveTo observe the effects of acupotomy therapy on synovial inflammation， macrophage polarization， and protein expressions of drosophila double-wing edge notch homologous gene 1 （Notch1）/Jagged typical Notch ligand 1 （Jagged1）/Hes family BHLH transcription factor 1 （Hes1） signaling pathway， so…
Juga tersedia di: DOAJ
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The Carcinogenicity of Alendronate in Patients with Osteoporosis: Evidence from Cohort Studies
CONTEXT: Alendronate may relate to the incidence of cancers, especially esophageal and colon cancer. But the results are inconsistent in different studies. OBJECTIVE: To quantify the association between the use of alendronate and the occurrence of different types of cancer. DATA SOURCES: We…
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Increased pollinator service and reduced pollen limitation in the fixed dune populations of a desert shrub
Evaluations of restoration success usually focus on the structural aspects of ecosystems. Pollination, as an important functional aspect, is often overlooked. Here, the shifts in pollinator assemblage and pollen limitation in the desert shrub Caragana microphylla were examined along a restoration…
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Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα(+) mesenchymal progenitors
BACKGROUND: Sarcopenia widely exists in elderly people and triggers numerous age‐related events. The essential pathologic change lies in the increased intramuscular adipose tissue after aging with no exception to non‐obese objects. Pim1 appears to be associated with adipogenic differentiation in…
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Age-related alterations of brain metabolic network based on [18F]FDG-PET of rats
Using animal models to study the underlying mechanisms of aging will create a critical foundation from which to develop new interventions for aging-related brain disorders. Aging-related reorganization of the brain network has been described for the human brain based on functional, metabolic and…
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Malnutrition and infection lead to poor prognosis and heavy financial burden of patients with chronic heart failure
BACKGROUND: Chronic heart failure (CHF) is a major public health concern, as it is associated with poor prognosis and heavy financial burden. In recent years, there has been increasing interest in medications for CHF in China, but few studies pay attention to the effects of nutrition and infection…
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Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice
Non-alcoholic fatty liver disease (NAFLD) is a chronic disease caused by hepatic steatosis. Adenosine deaminases acting on RNA (ADARs) catalyze adenosine to inosine RNA editing. However, the functional role of ADAR2 in NAFLD is unclear. ADAR2(+/+)/GluR-B(R/R) mice (wild type, WT) and…
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Nonsteroidal Anti-inflammatory Drugs as Prophylaxis for Heterotopic Ossification after Total Hip Arthroplasty
Heterotopic ossification (HO) is a frequent complication after total hip arthroplasty (THA). Nonsteroidal anti-inflammatory drugs (NSAIDs) have been used as routine prophylaxis for HO after THA. However, the efficacy of NSAIDs on HO, particularly selective NSAIDs versus nonselective NSAIDs, is…
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Inhibition of activator protein 1 attenuates neuroinflammation and brain injury after experimental intracerebral hemorrhage
AIMS: Intracerebral hemorrhage (ICH) is a devastating type of stroke without specific treatment. Activator protein 1 (AP‐1), as a gene regulator, initiates cytokine expression in response to environmental stimuli. In this study, we investigated the relationship between AP‐1 and…
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Effects of cortico-cortical paired associative stimulation based on multisensory integration to brain network connectivity in stroke patients: study protocol for a randomized doubled blind clinical trial
INTRODUCTION: : Brain has a spontaneous recovery after stroke, reflecting the plasticity of the brain. Currently, TMS is used for studies of single-target brain region modulation, which lacks consideration of brain networks and functional connectivity. Cortico-cortical paired associative…
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Epidemiology of traumatic spinal cord injury in Tianjin, China: An 18-year retrospective study of 735 cases
Study Design: Hospital-based retrospective study Objectives: To evaluate the pathogenetic features of traumatic spinal cord injury (TSCI) during 1999–2016 according to changed injury etiology with time, explore different characteristics of patients suffered a TSCI during 1999–2007 and 2008–2016 in…
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β-sheets in serum protein are independent risk factors for coronary lesions besides LDL-C in coronary heart disease patients
BACKGROUND: Coronary heart disease (CHD) patients with standard low-density lipoprotein cholesterol (LDL-C) remain at risk of cardiovascular events, making it critical to explore new targets to reduce the residual risk. The relationship between β-sheet conformation and CHD is gaining attention…
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Altered effective connectivity in the emotional network induced by immersive virtual reality rehabilitation for post-stroke depression
Post-stroke depression (PSD) is a serious complication of stroke that significantly restricts rehabilitation. The use of immersive virtual reality for stroke survivors is promising. Herein, we investigated the effects of a novel immersive virtual reality training system on PSD and explored induced…