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Environmental claims, climate promises, and ‘greenwashing’ by meat and dairy companies
Animal agriculture has disproportionate environmental impacts relative to other forms of food production and accounts for at least 16.5% of all global greenhouse gas (GHG) emissions. Many of the largest meat and dairy companies are aware of these environmental concerns and have responded by making…
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Environmental pathogen hazards reveal need for improved sanitation infrastructure in Alabama's Black Belt
Many rural communities in Alabama’s Black Belt region lack adequate sanitation, resulting in wastewater discharges that may pose risks to residents. To understand the scope of the problem in one community, we conducted three cross-sectional surveys in a small town with limited sanitation…
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Investigating the ME/CFS experience through qualitative analysis of memorial entries
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an impairing chronic condition characterized by exhaustion and worsening symptoms following exertion, often accompanied by pain, sleep issues, and cognitive issues. Historically, ME/CFS was not considered to be linked to mortality…
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High-intensity irreversible electroporation targeting intracellular structures enhance tumor ablation in lung cancer models
This study aimed to optimize irreversible electroporation (IRE) parameters to enhance intracellular injury, specifically targeting nuclear and mitochondrial structures that are insufficiently affected by conventional protocols. To address limitations of standard 1000 ~ 2500 V/cm clinical settings…
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Cadmium-induced DAG-PKC/IP 3 -Ca 2+ double signaling pathway and cell injury in gill of freshwater crabs Sinopotamon henanense
Cadmium (Cd) is an extremely toxic heavy metal and widespread in the environment, which has been demonstrated closely associated with numerous organs damage and even death. To evaluate the signaling pathway and the toxicity induced by Cd2+ in aquatic organisms, freshwater crabs Sinopotamon…
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Ten common mistakes that could ruin your enrichment analysis
Functional enrichment analysis (FEA) is an incredibly powerful way to summarise complex genomics data into information about the regulation of biological pathways including cellular metabolism, signalling and immune responses. About 10,000 scientific articles describe using FEA each year, making it…
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Uptrend in esotropia incidence in the era of excessive smartphone use: A nationwide population-based cohort study in Japan, 2014–2019
Acute acquired comitant esotropia (AACE) has recently garnered attention, as numerous case-series studies have reported its occurrence following excessive smartphone use. However, no large-scale epidemiological evidence of an increase in esotropia has been provided. This study aimed to investigate…
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Synthesis, surface activities, aggregation properties and oil washing performances of novel cardanol-based surfactants
A mixed cardanol sulfonate surfactant (MYBS) of disubstituted styrene unsaturated cardanol sulfonate (2,4-YBS) and monosubstituted styrene unsaturated cardanol sulfonate (2-YBS) was synthesized by optimizing the optimal synthesis conditions of the three-step reaction of alkylation, sulfonation and…
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Exploring gender-intentional implementation of Digital Health Information for Immunization in Ethiopia
Despite growing investment in digital health for immunization, there is limited evidence on how gender is considered into design and implementation. In 2022, Ethiopia launched a Gender-intentional Digital Health Information Roadmap with the support of Gavi, the Vaccine Alliance; however, the…
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Postgraduate medical education in fragile conflict-affected settings: A scoping review
Postgraduate medical education (PGME) is a vital pillar of health system resilience, yet it faces catastrophic disruption in Fragile Conflict-Affected settings. This review maps the fragmented body of evidence (current practices, challenges, quality indicators, and accreditation mechanisms)…
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Understanding how the informed consent process influences the decision to participate in an adaptive platform trial: A scoping review
Introduction: The complex design of adaptive platform trials may be challenging for prospective participants and their families and/or substitute decision makers to understand when approached for informed consent. The purpose of this scoping review is to explore and synthesize literature on how the…
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Magnitude and determinants of delivery complications among women in selected hospitals of West Shoa, Oromia, Ethiopia: A multicentered cross-sectional study
Background: The occurrence of Complications during delivery is a significant contributor to the health of the mothers and neonates, particularly in low-resource settings like Ethiopia. Assessing the magnitude and factors associated with it is essential for improving obstetric outcomes and having a…
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Cultivation potential of the tropical carrageenophyte Eucheumatopsis isiformis (Solieriaceae, Rhodophyta) from Yucatán, Mexico
The production of tropical red seaweeds, collectively referred to as eucheumatoids, has stagnated or declined over the past decade. This trend is primarily attributed to limited availability of high-quality planting material, increased incidence of diseases, and insufficient genetic exchange…
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Single-cell atlas of gastric cancer reveals malignant epithelial evolution and regulatory reprogramming of the tumor microenvironment
The inflammation–intestinal metaplasia (IM)–carcinoma cascade has been proposed as a framework for gastric cancer (GC) development, yet the cell-level heterogeneity and microenvironmental remodeling underlying this progression remain poorly characterized. Here, we constructed a single-cell…
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The longitudinal impact of smartphone dependency on happiness among children: A latent growth modeling approach
This study aimed to examine the longitudinal relationship between smartphone dependency and happiness among Korean children from fourth grade in elementary school through the first year of middle school (approximately ages 9–13), thereby providing an in-depth understanding of children’s emotional…
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How survivors of intimate partner violence experience trauma-informed care: A scoping review
Intimate partner violence [IPV] represents a worldwide public health concern, with most survivors experiencing the profound effects of its trauma. Survivors’ experiences of trauma-informed programs and approaches, however, are largely unknown. This scoping review therefore aimed to comprehensively…
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In search of novel PD1 inhibitor from natural products by high-throughput virtual screening and molecular dynamics simulation
Squamous cell carcinoma (SCC) represents a significant oncological challenge. While immune checkpoint inhibitors targeting PD-1/PD-L1 have revolutionized the treatment of SCC, current monoclonal antibody approaches face limitations, including poor tissue penetration, high costs, and immune-related…
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Single-cell multiomics data analysis of potential receptors and therapeutic drugs for epilepsy patients comorbid with depression
Depression frequently cooccurs with epilepsy (EP) and has become a focus of clinical management, but effective pharmacological interventions remain limited. In this study, single-cell RNA sequencing (scRNA-seq) data were analyzed to identify changes in oligodendrocyte precursor cells (OPCs) in EP…
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Screen Your Way Study Protocol: Embedding community driven models to increase cervical screening via HPV self-collection to improve cervical cancer outcomes for Aboriginal and Torres Strait Islander people
In July 2022, Human Papillomavirus (HPV) self-collection became available as a choice to all participants in Australia’s National Cervical Screening Program (NCSP). This policy change aims to facilitate equitable access to cervical screening; however, further evidence is needed to support its…
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Endorsement of the 32-item Consolidated Criteria for Reporting Qualitative (COREQ) and Standards for Reporting Qualitative Research (SRQR) by Chinese journals of nursing: A survey of editors and review of journal instructions for authors
Background: To investigate the endorsement of the 32-item Consolidated Criteria for Reporting Qualitative (COREQ) and Standards for Reporting Qualitative Research (SRQR) in the instructions for authors (IFA) of Chinese nursing journals. The awareness of Chinese editors of the COREQ and SRQR…
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