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Assembly and Budding of Ebolavirus
Ebolavirus is responsible for highly lethal hemorrhagic fever. Like all viruses, it must reproduce its various components and assemble them in cells in order to reproduce infectious virions and perpetuate itself. To generate infectious Ebolavirus, a viral genome-protein complex called the…
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Release of Sequestered Malaria Parasites upon Injection of a Glycosaminoglycan
Severe human malaria is attributable to an excessive sequestration of Plasmodium falciparum–infected and uninfected erythrocytes in vital organs. Strains of P. falciparum that form rosettes and employ heparan sulfate as a host receptor are associated with development of severe forms of malaria…
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Trypanin, a Component of the Flagellar Dynein Regulatory Complex, Is Essential in Bloodstream Form African Trypanosomes
The Trypanosoma brucei flagellum is a multifunctional organelle with critical roles in motility, cellular morphogenesis, and cell division. Although motility is thought to be important throughout the trypanosome lifecycle, most studies of flagellum structure and function have been restricted to the…
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Correction: Alpha-Herpesvirus Infection Induces the Formation of Nuclear Actin Filaments
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Artikel Jurnal Teks lengkap
Rescue of Progeria in Trichothiodystrophy by Homozygous Lethal Xpd Alleles
Although compound heterozygosity, or the presence of two different mutant alleles of the same gene, is common in human recessive disease, its potential to impact disease outcome has not been well documented. This is most likely because of the inherent difficulty in distinguishing specific biallelic…
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tRNAs Promote Nuclear Import of HIV-1 Intracellular Reverse Transcription Complexes
Infection of non-dividing cells is a biological property of HIV-1 crucial for virus transmission and AIDS pathogenesis. This property depends on nuclear import of the intracellular reverse transcription and pre-integration complexes (RTCs/PICs). To identify cellular factors involved in nuclear…
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The Case of XPD: Sometimes Two Different Mutant Genes Are Better than One
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Artikel Jurnal Teks lengkap
Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
Background: Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-sensitive transcription factor that positively regulates the expression of genes encoding antioxidants, xenobiotic detoxification enzymes, and drug efflux pumps, and confers cytoprotection against oxidative stress and…
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Artikel Jurnal Teks lengkap
Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction
Background: A limited number of studies have assessed the risk of common diseases when combining information from several predisposing polymorphisms. In most cases, individual polymorphisms only moderately increase risk (~20%), and they are thought to be unhelpful in assessing individuals' risk…
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Tuberculosis Recurrence and Mortality after Successful Treatment: Impact of Drug Resistance
Background: The DOTS (directly observed treatment short-course) strategy for tuberculosis (TB) control is recommended by the World Health Organization globally. However, there are few studies of long-term TB treatment outcomes from DOTS programs in high-burden settings and particularly settings of…
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A Comparative Analysis of Influenza Vaccination Programs
Background: The threat of avian influenza and the 2004–2005 influenza vaccine supply shortage in the United States have sparked a debate about optimal vaccination strategies to reduce the burden of morbidity and mortality caused by the influenza virus. Methods and Findings: We present a comparative…
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Antidepressant Prevention of Postnatal Depression
A systematic review sought to discover whether antidepressant drugs are effective in preventing postnatal depression. Only two small trials were found and it was not possible to draw firm conclusions.
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Artikel Jurnal Teks lengkap
Five Myths about the HIV Epidemic in Asia
Godwin and colleagues say that there are several myths about the HIV epidemic in Asia, myths that are disseminated in both public and professional discourse and that often dominate policy and political debate.
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Simulating Properties of In Vitro Epithelial Cell Morphogenesis
How do individual epithelial cells (ECs) organize into multicellular structures? ECs are studied in vitro to help answer that question. Characteristic growth features include stable cyst formation in embedded culture, inverted cyst formation in suspension culture, and lumen formation in overlay…
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Natural Biocombinatorics in the Polyketide Synthase Genes of the Actinobacterium Streptomyces avermitilis
Modular polyketide synthases (PKSs) of bacteria provide an enormous reservoir of natural chemical diversity. Studying natural biocombinatorics may aid in the development of concepts for experimental design of genes for the biosynthesis of new bioactive compounds. Here we address the question of how…
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Mutation at the Evi1 Locus in Junbo Mice Causes Susceptibility to Otitis Media
Otitis media (OM), inflammation of the middle ear, remains the most common cause of hearing impairment in children. It is also the most common cause of surgery in children in the developed world. There is evidence from studies of the human population and mouse models that there is a significant…
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Application of Genome-Wide Single Nucleotide Polymorphism Typing: Simple Association and Beyond
The International HapMap Project and the arrival of technologies that type more than 100,000 SNPs in a single experiment have made genome-wide single nucleotide polymorphism (GW-SNP) assay a realistic endeavor. This has sparked considerable debate regarding the promise of GW-SNP typing to identify…
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Heat-Shock Promoters: Targets for Evolution by P Transposable Elements in Drosophila
Transposable elements are potent agents of genomic change during evolution, but require access to chromatin for insertion—and not all genes provide equivalent access. To test whether the regulatory features of heat-shock genes render their proximal promoters especially susceptible to the insertion…
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