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Supply chain carbon reduction considering consumer skepticism and blockchain technology under the cap-and-trade policy
In the context of low-carbon development, both firms and consumers can contribute to environmental protection. Given that consumers are often skeptical of corporate claims regarding product carbon reductions, this study explores how manufacturers can leverage blockchain technology to invest in…
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Knowledge, attitudes, and practices (KAPs) on agrochemical use in small-scale farmers near Lake Tana, Ethiopia: Impacts on public and aquatic ecosystem health
Agrochemical application is essential for increasing agricultural production and achieving Sustainable Development Goal 1 to secure worldwide hunger. In Ethiopia, there is haphazard use of pesticides for agricultural intensifications. However, knowledge, attitudes, and practices (KAPs) regarding…
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Non-lethal imaging and modeling approaches for estimating dry mass in aquatic larvae
Body mass is crucial for scaling and comparing physiological rates. Specifically, dry body mass is important in determining an organism’s metabolic rate since it excludes metabolically inactive water weight. While obtaining repeated measurements of body mass throughout an individual’s lifetime is…
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Treatment sequence patterns of urate-lowering therapy in Korean patients with gout: A common data model-based study
Background: A treat-to-target strategy involving treatment modification improves outcomes in gout, but evidence remains limited regarding the optimal approach when initial urate-lowering therapy (ULT) fails. This study aimed to investigate real-world ULT sequence patterns and evaluate treatment…
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Strategies to improve sexual health in women with urinary incontinence: A scoping review
Background: Urinary incontinence (UI), affecting 3%–55% of women worldwide, significantly impairs sexual health and quality of life. Despite its prevalence, interventions targeting sexual dysfunction in this population are understudied. This scoping review synthesizes evidence on strategies to…
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Integrating SolVES and social media analytics to quantify social value spatial patterns and driving mechanisms in mega-scale green spaces
Assessing the social values (SVs) of mega-scale green spaces (MSGs) in regenerated brownfields remains challenging due to spatial heterogeneity and perceptual dynamics. This study developed a dual-modal framework integrating the Social Values for Ecosystem Services (SolVES) model and social media…
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COVID-19 in hemodialysis patients: New insights into metabolomic profile dynamics from 60 days pre- to 60 days post-diagnosis
Background: Maintenance hemodialysis patients experience higher morbidity and mortality from COVID-19, partly due to comorbidities like diabetes and cardiovascular disease. However, kidney disease-related metabolic processes may also contribute. Methods: In this prospective, multi-center…
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The intrinsic structure and interrelations of tea culture constructed from tea-related toponym texts: Evidence from China
Tea culture is an important part of the regional culture and intangible cultural heritage that is valued and favored worldwide. The connotations of tea culture are mapped and precipitated in toponyms, which significantly influence the naming and renaming of said toponyms. However, rigorous research…
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Sexually transmitted infection prevalence and Neisseria gonorrhoeae antimicrobial resistance patterns in men who have sex with men with or without urethral discharge syndrome in Johannesburg, South Africa, 2024
We conducted a cross-sectional study to estimate the prevalence of urogenital and extragenital sexually transmitted infections (STIs) among men who have sex with men (MSM) with and without urethral discharge syndrome, to assess infections missed by syndromic management, and to describe phenotypic…
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The association between RDW-to-platelet ratio and in-hospital mortality in critically ill stroke patients: A retrospective cohort study based on the eICU database
Objective: The red cell distribution width-to-platelet ratio (RDW-to-platelet ratio, RPR) is a potential biomarker of inflammation and bone marrow function. This study aimed to investigate the association between RPR and in-hospital mortality in critically ill stroke patients in the eICU, and to…
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Engaging communities in addressing antimicrobial resistance: Co-producing locally relevant public health messages
Antimicrobial resistance (AMR) is a critical global health challenge that weakens the effective treatment of common infections and threatens health system functioning, particularly in settings where access to affordable healthcare and regulated medicines is limited. This study explores whether…
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Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline
Neurons rely on glial ‘lactate shuttling’ for metabolic support, which declines with aging and in neurodegenerative disease. Full disruption of lactate shuttling in peripheral nerves causes progressive axon degeneration, but we were interested to understand how partial disruption, a scenario more…
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A protocol to establish and maintain organotypic cerebellar slice culture (OCerSC) from aged mice
Organotypic slice culture is a sophisticated technique historically used in cellular and developmental neurobiology to investigate three-dimensional architecture and cellular interactions. Maintaining thin tissue slices preserves organotypic structure and more accurately reflects the in vivo…
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Measuring vaccine effects on antibiotic use and antimicrobial resistance in low and middle-income countries: A scoping review of methodological approaches, data sources, metrics, and limitations
Vaccines represent a critical strategy for combating antimicrobial resistance (AMR), yet methodological approaches for assessing their impact remain heterogeneous, particularly in low- and middle-income countries (LMICs) where both infectious disease and resistance burdens are highest. This scoping…
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Machine Learning-Based Pattern Recognition of Risk Factors for Low Back Pain among Adolescent Cricket Players in Dhaka City
Low back pain (LBP) is common among adolescent cricketers, often due to repetitive lumbar stress. This study investigated LBP among 450 adolescent cricketers in Dhaka City, Bangladesh, considering a range of factors, including sociodemographic characteristics, game-related activities, preventive…
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Prevalence of significant depressive symptoms and associated factors among facially disfigured pediatric Noma patients in Nigeria: A single-centre cross-sectional study
Noma is a neglected tropical disease that causes severe facial disfigurement and significant morbidity, yet there is limited evidence regarding the psychological well-being of affected children. This study aimed to determine the prevalence of depressive symptoms and identify associated factors…
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‘Backpropagation and the brain’ realized in cortical error neuron microcircuits
Neural responses to mismatches between expected and actual stimuli have been widely reported across different species. How does the brain use such error signals for learning? While global error signals can be useful, their ability to learn complex computation at the scale observed in the brain is…
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Spatial analysis of under-five children mortality and associated determinants in Ghana: Mapping regional disparities for targeted interventions
Child mortality is a critical measure of healthcare performance, with Sustainable Development Goal 3.2 targeting reductions in neonatal and under-five mortality to 12 and 25 deaths per 1,000 live births, respectively, by 2030. However, Ghana’s child mortality rate remains high at 32 deaths per…
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A pyroptosis-related gene signature for the diagnosis of acute pancreatitis
Acute pancreatitis (AP) is a severe inflammatory disorder in which pyroptosis—a pro-inflammatory form of programmed cell death—may contribute to pathogenesis. However, the complete transcriptional profile of pyroptosis-related genes (PRGs) in AP and their potential as diagnostic biomarkers remain…
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Common hemoglobin variants affecting the diagnosis of β-thalassemia: A large cohort data at a single center
Background: Many globin chain variants were interpreted as β-thalassemia or hereditary persistence of fetal hemoglobin (HPFH) at routine investigation. We described this in a large cohort of Thai subjects. Methods: Hematological data of 43,414 subjects encountered at our thalassemia diagnostic…
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