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Artikel Jurnal Teks lengkap
Novel Therapies for Tuberculosis: Tuberculosis Control and its Discontents
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Artikel Jurnal Teks lengkap
Preterm Birth: Effect of Corticosteroids or Immediate Cord Clamping?
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Artikel Jurnal Teks lengkap
Time to Renal Disease and End-Stage Renal Disease in PROFILE: A Multiethnic Lupus Cohort
Background: Renal involvement is a serious manifestation of systemic lupus erythematosus (SLE); it may portend a poor prognosis as it may lead to end-stage renal disease (ESRD). The purpose of this study was to determine the factors predicting the development of renal involvement and its…
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Artikel Jurnal Teks lengkap
Dementia before Death in Ageing Societies— The Promise of Prevention and the Reality
Background: Dementia and severe cognitive impairment are very closely linked to ageing. The longer we live the more likely we are to suffer from these conditions. Given population increases in longevity it is important to understand not only risk and protective factors for dementia and severe…
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Artikel Jurnal Teks lengkap
HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8 + T Cell Response against HIV-1
Background: Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression. Methods and Findings: In a cohort of 104 individuals with primary HIV-1…
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Artikel Jurnal Teks lengkap
Analysis of Gene Expression Using Gene Sets Discriminates Cancer Patients with and without Late Radiation Toxicity
Background: Radiation is an effective anti-cancer therapy but leads to severe late radiation toxicity in 5%–10% of patients. Assuming that genetic susceptibility impacts this risk, we hypothesized that the cellular response of normal tissue to X-rays could discriminate patients with and without…
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Artikel Jurnal Teks lengkap
Methods of Blinding in Reports of Randomized Controlled Trials Assessing Pharmacologic Treatments: A Systematic Review
Background: Blinding is a cornerstone of therapeutic evaluation because lack of blinding can bias treatment effect estimates. An inventory of the blinding methods would help trialists conduct high-quality clinical trials and readers appraise the quality of results of published trials. We aimed to…
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Artikel Jurnal Teks lengkap
Correction: Frequency of Adverse Events after Vaccination with Different Vaccinia Strains
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Artikel Jurnal Teks lengkap
Can We Prevent, Delay, or Shorten the Course of Dementia?
Van Gool discusses a new study that found that the prevalence of dementia and severe cognitive impairment in the year before death rises steeply with age.
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Artikel Jurnal Teks lengkap
Atypical Haemolytic Uraemic Syndrome Associated with a Hybrid Complement Gene
Background: Sequence analysis of the regulators of complement activation (RCA) cluster of genes at chromosome position 1q32 shows evidence of several large genomic duplications. These duplications have resulted in a high degree of sequence identity between the gene for factor H (CFH) and the genes…
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Artikel Jurnal Teks lengkap
Mapping the Economic Costs and Benefits of Conservation
Resources for biodiversity conservation are severely limited, requiring strategic investment. Understanding both the economic benefits and costs of conserving ecosystems will help to allocate scarce dollars most efficiently. However, although cost-benefit analyses are common in many areas of…
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Artikel Jurnal Teks lengkap
Human Immunodeficiency Virus Impairs Reverse Cholesterol Transport from Macrophages
Several steps of HIV-1 replication critically depend on cholesterol. HIV infection is associated with profound changes in lipid and lipoprotein metabolism and an increased risk of coronary artery disease. Whereas numerous studies have investigated the role of anti-HIV drugs in lipodystrophy and…
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