3.382 hasil
Menampilkan 761–780 · 0,15 detik · RSS
-
Artikel Jurnal Teks lengkap
Phenotypic Plasticity Opposes Species Invasions by Altering Fitness Surface
Understanding species invasion is a central problem in ecology because invasions of exotic species severely impact ecosystems, and because invasions underlie fundamental ecological processes. However, the influence on invasions of phenotypic plasticity, a key component of many species interactions…
-
Artikel Jurnal Teks lengkap
Conservation Planning for Ecosystem Services
Despite increasing attention to the human dimension of conservation projects, a rigorous, systematic methodology for planning for ecosystem services has not been developed. This is in part because flows of ecosystem services remain poorly characterized at local-to-regional scales, and their…
-
Artikel Jurnal Teks lengkap
Recombination Hotspots Flank the Cryptococcus Mating-Type Locus: Implications for the Evolution of a Fungal Sex Chromosome
Recombination increases dramatically during meiosis to promote genetic exchange and generate recombinant progeny. Interestingly, meiotic recombination is unevenly distributed throughout genomes, and, as a consequence, genetic and physical map distances do not have a simple linear relationship…
-
Artikel Jurnal Teks lengkap
CAF-1 Is Essential for Heterochromatin Organization in Pluripotent Embryonic Cells
During mammalian development, chromatin dynamics and epigenetic marking are important for genome reprogramming. Recent data suggest an important role for the chromatin assembly machinery in this process. To analyze the role of chromatin assembly factor 1 (CAF-1) during pre-implantation development…
-
Artikel Jurnal Teks lengkap
Selection Acts on DNA Secondary Structures to Decrease Transcriptional Mutagenesis
Single-stranded DNA is more subject to mutation than double stranded. During transcription, DNA is transiently single stranded and therefore subject to higher mutagenesis. However, if local intra-strand secondary structures are formed, some bases will be paired and therefore less sensitive to…
-
Artikel Jurnal Teks lengkap
The Evolution of Two-Component Systems in Bacteria Reveals Different Strategies for Niche Adaptation
Two-component systems including histidine protein kinases represent the primary signal transduction paradigm in prokaryotic organisms. To understand how these systems adapt to allow organisms to detect niche-specific signals, we analyzed the phylogenetic distribution of nearly 5,000 histidine…
-
Artikel Jurnal Teks lengkap
The Evolution of Word Composition in Metazoan Promoter Sequence
The field of molecular evolution provides many examples of the principle that molecular differences between species contain information about evolutionary history. One surprising case can be found in the frequency of short words in DNA: more closely related species have more similar word…
-
Artikel Jurnal Teks lengkap
Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates Erythrocyte Invasion
Erythrocytic malaria parasites utilize proteases for a number of cellular processes, including hydrolysis of hemoglobin, rupture of erythrocytes by mature schizonts, and subsequent invasion of erythrocytes by free merozoites. However, mechanisms used by malaria parasites to control protease…
-
Artikel Jurnal Teks lengkap
PGC-1β: A Regulator of Mitochondrial Function with Subtle Roles in Energy Metabolism
-
Artikel Jurnal Teks lengkap
Metagenomics Offers a Big-Picture View of the Diversity and Distribution of Marine Viruses
-
Artikel Jurnal Teks lengkap
Criteria for Drugs Used in Pre-Exposure Prophylaxis Trials against HIV Infection
The authors formulate criteria for an optimal pre-exposure prophylaxis drug candidate, and evaluate existing antiviral drug classes for their suitability.
-
Artikel Jurnal Teks lengkap
Internet Use among Ugandan Adolescents: Implications for HIV Intervention
Background: The Internet is fast gaining recognition as a powerful, low-cost method to deliver health intervention and prevention programs to large numbers of young people across diverse geographic regions. The feasibility and accessibility of Internet-based health interventions in resource-limited…
-
Artikel Jurnal Teks lengkap
Educating Health Professionals about Drug and Device Promotion: Advocates' Recommendations
Mansfield and colleagues outline the recommendations from four advocacy groups for improving the education of health professionals on promotion of drugs and devices.
-
Artikel Jurnal Teks lengkap
Targeted Killing of Virally Infected Cells by Radiolabeled Antibodies to Viral Proteins
Background: The HIV epidemic is a major threat to health in the developing and western worlds. A modality that targets and kills HIV-1-infected cells could have a major impact on the treatment of acute exposure and the elimination of persistent reservoirs of infected cells. The aim of this…
-
Artikel Jurnal Teks lengkap
Disease Biomarkers in Cerebrospinal Fluid of Patients with First-Onset Psychosis
Background: Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs. There are numerous psychiatric conditions that present with psychotic symptoms, most importantly schizophrenia, bipolar…
-
Artikel Jurnal Teks lengkap
The Marine Viromes of Four Oceanic Regions
Viruses are the most common biological entities in the marine environment. There has not been a global survey of these viruses, and consequently, it is not known what types of viruses are in Earth's oceans or how they are distributed. Metagenomic analyses of 184 viral assemblages collected over a…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.