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Limited protection against early-life lung murine cytomegalovirus infection results from deficiency of cytotoxic CD8 T cells
Differential antiviral T cell immunity in early life impacts the clinical outcome of Cytomegalovirus (CMV) infection, but the underlying mechanisms are not well understood. T cells are known to be involved in protection from CMV disease. To further elucidate these mechanisms, we used a model of…
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Dominance modifiers at the Arabidopsis self-incompatibility locus retain proto-miRNA features and act through non-canonical pathways
Self-incompatibility in flowering plants is a common mechanism that prevents self-fertilization and promotes outcrossing. In Brassicaceae, the self-incompatibility locus is highly diverse, with many alleles arranged in a complex dominance hierarchy and exhibiting monoallelic expression in…
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Molecular investigation of diverse Aedes aegypti in heightened dengue transmission settings in Somaliland, 2023–2024
Anthropogenic factors have contributed to the expansion of the dengue vector Aedes aegypti into previously non-endemic regions. In East Africa, rising dengue cases highlight gaps in understanding the role of Ae. aegypti. Here, we present a molecular characterization of Ae. aegypti in Somaliland…
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Population pharmacokinetics of DNDI-6148 in healthy adults
Leishmaniasis (both visceral and cutaneous) and Chagas disease (CD) are among the most neglected tropical diseases, with limited treatment options and an urgent need for safer, more effective therapies. DNDI-6148, a benzoxaborole with anti-leishmanial and antichagasic activity, is currently under…
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Effects of rehabilitation and behavior change interventions on physical capacity and physical activity behavior following lumbar surgery for degenerative disease: A systematic review and meta-analysis
Background: Rehabilitation and behavior change interventions are commonly used after lumbar surgery to improve recovery, but their effects on physical capacity and physical activity remain unclear. This study aimed to investigate the effectiveness of rehabilitation and behavior change interventions…
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Gaps in knowledge and use of artemether-lumefantrine among university students in Southwestern Nigeria: A cross-sectional study
Inappropriate use of antimalarial medications can accelerate the development of antimicrobial resistance (AMR), undermining treatment efficacy and public health goals. Artemether-lumefantrine (A/L) is the first-line treatment for uncomplicated malaria in Nigeria, yet its misuse persists…
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Genetic complementation reveals structure-function links in nodavirus RNA replication complex crowns
Positive-strand RNA viruses replicate their RNA genomes in virus-induced, membrane-bounded organelles. As first found for nodaviruses, the necked cytosolic portals of these organelles bear ringed “crown” complexes of viral RNA replication proteins that drive synthesis, capping and release of new…
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A novel multi-objective dynamic flexible job shop scheduling algorithm using reinforced learning based black widow spider algorithm
In today’s fast-paced manufacturing environments, solving flexible job shop scheduling problem (FJSP) has become essential due to swift design-to-manufacturing-to-consumer cycle and frequent disruptive events like new job arrivals. This study proposes a novel reinforcement learning based black…
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Multi-level determinants of tuberculosis treatment completion in rural Uganda: A cross-sectional study
Background: Tuberculosis (TB) treatment completion rates in high-burden countries like Uganda often fall short of the WHO End TB Strategy target of ≥90%. This study evaluated multilevel determinants of treatment completion to guide evidence-based improvement strategies in rural Western Uganda…
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Reconsidering the context in the relationship between material deprivation and self-rated health among older people in Italy
Both personal characteristics and contextual factors shape an individual’s perception of their health. This is especially true among older people. Micro and macro data from the 2018 Italian Multipurpose Survey on Households and a two-step model have been used here to investigate the extent to which…
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A cross-dataset harmonized intrusion detection framework with statistically validated multi-model learning
Intrusion Detection Systems (IDS) are considered critical security tools in ensuring network infrastructure security. However, recent studies on machine learning-based IDS systems are often constrained by their heavy dependence on a single dataset, lack of reproducibility, and lack of transparency…
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Distributions of plantar loads are altered when walking in anxiety-inducing virtual settings but not under cognitive demand
Additional cognitive load and fall-related anxiety alter balance and locomotor control, independent of motor demands. Exposing participants to virtual elevation increases perceived cost of falling, and individuals alter the distribution of medial and lateral plantar loading to maintain balance and…
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Subthreshold depression prevalence and influencing factors among nursing students in vocational schools: A cross-sectional study
Background: Subthreshold depression (SD) is defined as a subclinical symptomatic state characterized by depressive symptoms that do not meet diagnostic criteria yet still impair quality of life and functioning. The prevalence of this condition is notably high among adolescents. Vocational nursing…
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Vector-borne disease surveillance and control resource needs in Colorado public health organizations
Since 2002, Colorado has experienced a high vector-borne disease (VBD) burden from diseases like West Nile fever, plague, and tularemia. Recent evidence underscores a lack of vector-borne surveillance and control program capacity across public health organizations, prompting our evaluation of…
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Association between parenthood and survival among 30,386 patients hospitalized with COVID-19
Background: Cross-reactive immune responses between endemic human coronaviruses and SARS-CoV-2 have been proposed as a potential factor mitigating COVID-19 severity. Because parents may have more frequent exposure to seasonal respiratory viruses through contact with children, we investigated…
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Acupuncture for amnestic mild cognitive impairment: Study protocol for a multicenter, single-blinded, long-term, randomized controlled trial
Background: Amnestic mild cognitive impairment (aMCI), a common neurodegenerative disease affecting older adults, has garnered significant research interest over the past few years. While previous studies have suggested that acupuncture holds promise as a clinical intervention to improve cognitive…
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Artikel Jurnal Teks lengkap
Global folate deficiency among adolescent girls: A systematic review and meta-analysis
Introduction: Adolescents have higher nutrient requirements than adults, as this stage accounts for approximately 40% of total adult weight gain, 45% of skeletal mass and about 15% of adult height. Adequate micronutrient intake is particularly essential for adolescent girls to support growth…
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Diagnostic performance of DNA index for detection of high hyperdiploidy in childhood B-cell acute lymphoblastic leukemia
Introduction: High hyperdiploidy (HHD) is the most common cytogenetic abnormality in childhood B-cell acute lymphoblastic leukemia (B-ALL) and is a pivotal finding for prognosis evaluation and treatment stratification. Karyotyping is considered the gold standard for detecting HHD; however…
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Identification of an optimal exogenous gene insertion site (P–M) and establishment of a reverse genetics system for aMPV/A
Avian metapneumovirus subgroup A (aMPV/A) causes widespread infections in commercial poultry worldwide. The development of highly efficient viral vector vaccines is constrained by multiple factors, among which the lack of a mature reverse genetics system and the uncertainty regarding the optimal…
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Association of polycythemia with outcomes of acute decompensated heart failure: A matched and weighted cohort analysis
Aims: The prognostic significance of polycythemia in acute decompensated heart failure (ADHF) is unclear. This study aimed to evaluate the clinical profile and prognostic implications of polycythemia compared with anemia and normocythemia in patients hospitalized with ADHF. Materials and methods…
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