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Lymphotoxin-α Gene and Risk of Myocardial Infarction in 6,928 Cases and 2,712 Controls in the ISIS Case-Control Study
Lymphotoxin-α (LTA) is a pro-inflammatory cytokine that plays an important role in the immune system and local inflammatory response. LTA is expressed in atherosclerotic plaques and has been implicated in the pathogenesis of atherosclerosis and coronary heart disease (CHD). Polymorphisms in the…
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Two Membrane-Associated Tyrosine Phosphatase Homologs Potentiate C. elegans AKT-1/PKB Signaling
Akt/protein kinase B (PKB) functions in conserved signaling cascades that regulate growth and metabolism. In humans, Akt/PKB is dysregulated in diabetes and cancer; in Caenorhabditis elegans, Akt/PKB functions in an insulin-like signaling pathway to regulate larval development. To identify…
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Critical Role of Bcr1-Dependent Adhesins in C. albicans Biofilm Formation In Vitro and In Vivo
The fungal pathogen Candida albicans is frequently associated with catheter-based infections because of its ability to form resilient biofilms. Prior studies have shown that the transcription factor Bcr1 governs biofilm formation in an in vitro catheter model. However, the mechanistic role of the…
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Live Attenuated B. pertussis as a Single-Dose Nasal Vaccine against Whooping Cough
Pertussis is still among the principal causes of death worldwide, and its incidence is increasing even in countries with high vaccine coverage. Although all age groups are susceptible, it is most severe in infants too young to be protected by currently available vaccines. To induce strong…
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Nuclear Retention of Multiply Spliced HIV-1 RNA in Resting CD4 + T Cells
HIV-1 latency in resting CD4+ T cells represents a major barrier to virus eradication in patients on highly active antiretroviral therapy (HAART). We describe here a novel post-transcriptional block in HIV-1 gene expression in resting CD4+ T cells from patients on HAART. This block involves the…
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The Potential Impact of Male Circumcision on HIV in Sub-Saharan Africa
Background: A randomized controlled trial (RCT) has shown that male circumcision (MC) reduces sexual transmission of HIV from women to men by 60% (32%−76%; 95% CI) offering an intervention of proven efficacy for reducing the sexual spread of HIV. We explore the implications of this finding for the…
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Reducing Disparities in the Burden of Cancer: The Role of Patient Navigators
Many racial and ethnic minority patients with cancer face barriers related to access to health care and information. Patient navigators, say the authors, could help to overcome these barriers.
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Dinosaur Fossils Predict Body Temperatures
Perhaps the greatest mystery surrounding dinosaurs concerns whether they were endotherms, ectotherms, or some unique intermediate form. Here we present a model that yields estimates of dinosaur body temperature based on ontogenetic growth trajectories obtained from fossil bones. The model predicts…
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In the Ant's Garden, Fungal Parasites Are Closely Matched to Their Fungal Hosts
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Data Sharing: How Much Doesn't Get Submitted to GenBank?
Funding agencies and journals require researchers to deposit DNA sequences in public databases such as GenBank when the paper is published, but how often do authors fail to do so?
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Ancient Host–Pathogen Associations Maintained by Specificity of Chemotaxis and Antibiosis
Switching by parasites to novel hosts has profound effects on ecological and evolutionary disease dynamics. Switching requires that parasites are able to establish contact with novel hosts and to overcome host defenses. For most host–parasite associations, it is unclear as to what specific…
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Moving Toward Assured Access to Treatment in Microbicide Trials
Anna Forbes discusses the Global Campaign for Microbicides' consensus statement on access to treatment and standards of care in microbicide trials.
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Building Surgical Research Capacity in Africa: The Ptolemy Project
The authors describe the Ptolemy Project, a recently developed model of electronic access to medical literature for surgeons in developing countries.
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Regulation of Clinical Research Sponsored by Pharmaceutical Companies: A Proposal
Sotelo proposes that a third party, appointed by academic institutions, must be compulsorily placed between clinical researchers and drug companies.
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Correction: Advertising in Medical Journals: Should Current Practices Change?
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Artikel Jurnal Teks lengkap
Intronic Alternative Splicing Regulators Identified by Comparative Genomics in Nematodes
Many alternative splicing events are regulated by pentameric and hexameric intronic sequences that serve as binding sites for splicing regulatory factors. We hypothesized that intronic elements that regulate alternative splicing are under selective pressure for evolutionary conservation. Using a…
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Wiggle—Predicting Functionally Flexible Regions from Primary Sequence
The Wiggle series are support vector machine–based predictors that identify regions of functional flexibility using only protein sequence information. Functionally flexible regions are defined as regions that can adopt different conformational states and are assumed to be necessary for bioactivity…
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