3.382 hasil
Menampilkan 881–900 · 1,58 detik · RSS
-
Artikel Jurnal Teks lengkap
“Key to the Future”: British American Tobacco and Cigarette Smuggling in China
Background: Cigarette smuggling is a major public health issue, stimulating increased tobacco consumption and undermining tobacco control measures. China is the ultimate prize among tobacco's emerging markets, and is also believed to have the world's largest cigarette smuggling problem. Previous…
-
Artikel Jurnal Teks lengkap
Immunoprophylaxis against Mother-to-Child Transmission of HIV-1
The authors discuss a new study in PLoS Medicine that examines whether human anti-HIV monoclonal antibodies might be useful in South Africa for preventing mother-to-child transmission of subtype C HIV viruses.
-
Artikel Jurnal Teks lengkap
Evaluating Health Research Capacity Building: An Evidence-Based Tool
Bates and colleagues describe the development of a tool to assess capacity-building programs in health research, which they used in Kumasi, Ghana.
-
Artikel Jurnal Teks lengkap
The “Ultimate Prize” for Big Tobacco: Opening the Chinese Cigarette Market by Cigarette Smuggling
Novotny discusses a new study in PLoS Medicine that documents how British American Tobacco has exploited China's large cigarette smuggling problem.
-
Artikel Jurnal Teks lengkap
A New Mouse Model to Study Acquired Lymphedema
Schneider and colleagues say that the new model, published in PLoS Medicine, promises to increase our understanding of lymphedema and hopefully accelerate the development and testing of new treatments.
-
Artikel Jurnal Teks lengkap
A Survey of Public Funding of Cancer Research in the European Union
The European Cancer Research Funding Survey found inadequate public funding of cancer research, say Sullivan and Eckhouse.
-
Artikel Jurnal Teks lengkap
Core Verbal Autopsy Procedures with Comparative Validation Results from Two Countries
Background: Cause-specific mortality statistics remain scarce for the majority of low-income countries, where the highest disease burdens are experienced. Neither facility-based information systems nor vital registration provide adequate or representative data. The expansion of sample vital…
-
Artikel Jurnal Teks lengkap
MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia
Background: The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF). Subsequent analysis has shown that constitutive activation of the JAK-STAT signal transduction pathway is an…
-
Artikel Jurnal Teks lengkap
Toward a Census of Bacteria in Soil
For more than a century, microbiologists have sought to determine the species richness of bacteria in soil, but the extreme complexity and unknown structure of soil microbial communities have obscured the answer. We developed a statistical model that makes the problem of estimating richness…
-
Artikel Jurnal Teks lengkap
Complex Parameter Landscape for a Complex Neuron Model
The electrical activity of a neuron is strongly dependent on the ionic channels present in its membrane. Modifying the maximal conductances from these channels can have a dramatic impact on neuron behavior. But the effect of such modifications can also be cancelled out by compensatory mechanisms…
-
Artikel Jurnal Teks lengkap
Nonoptimal Component Placement, but Short Processing Paths, due to Long-Distance Projections in Neural Systems
It has been suggested that neural systems across several scales of organization show optimal component placement, in which any spatial rearrangement of the components would lead to an increase of total wiring. Using extensive connectivity datasets for diverse neural networks combined with spatial…
-
Artikel Jurnal Teks lengkap
Key Role of Local Regulation in Chemosensing Revealed by a New Molecular Interaction-Based Modeling Method
The signaling network underlying eukaryotic chemosensing is a complex combination of receptor-mediated transmembrane signals, lipid modifications, protein translocations, and differential activation/deactivation of membrane-bound and cytosolic components. As such, it provides particularly…
-
Artikel Jurnal Teks lengkap
Extracting Gene Networks for Low-Dose Radiation Using Graph Theoretical Algorithms
Genes with common functions often exhibit correlated expression levels, which can be used to identify sets of interacting genes from microarray data. Microarrays typically measure expression across genomic space, creating a massive matrix of co-expression that must be mined to extract only the most…
-
Artikel Jurnal Teks lengkap
Protein–Protein Interactions More Conserved within Species than across Species
Experimental high-throughput studies of protein–protein interactions are beginning to provide enough data for comprehensive computational studies. Today, about ten large data sets, each with thousands of interacting pairs, coarsely sample the interactions in fly, human, worm, and yeast. Another…
-
Artikel Jurnal Teks lengkap
Transcriptional Profiling of Aging in Human Muscle Reveals a Common Aging Signature
We analyzed expression of 81 normal muscle samples from humans of varying ages, and have identified a molecular profile for aging consisting of 250 age-regulated genes. This molecular profile correlates not only with chronological age but also with a measure of physiological age. We compared the…
-
Artikel Jurnal Teks lengkap
Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations
Eukaryotic cells possess several mechanisms to protect the integrity of their DNA against damage. These include cell-cycle checkpoints, DNA-repair pathways, and also a distinct DNA damage–tolerance system that allows recovery of replication forks blocked at sites of DNA damage. In both humans and…
-
Artikel Jurnal Teks lengkap
Structural Model Analysis of Multiple Quantitative Traits
We introduce a method for the analysis of multilocus, multitrait genetic data that provides an intuitive and precise characterization of genetic architecture. We show that it is possible to infer the magnitude and direction of causal relationships among multiple correlated phenotypes and illustrate…
-
Artikel Jurnal Teks lengkap
The Ancestral Eutherian Karyotype Is Present in Xenarthra
Molecular studies have led recently to the proposal of a new super-ordinal arrangement of the 18 extant Eutherian orders. From the four proposed super-orders, Afrotheria and Xenarthra were considered the most basal. Chromosome-painting studies with human probes in these two mammalian groups are…
-
Artikel Jurnal Teks lengkap
Randomised Trial of Chloroquine/Sulphadoxine-Pyrimethamine in Gambian Children with Malaria: Impact against Multidrug-Resistant P. falciparum
Objectives: In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence of parasites carrying alleles associated…
-
Artikel Jurnal Teks lengkap
Chloroquine/Sulphadoxine-Pyrimethamine for Gambian Children with Malaria: Transmission to Mosquitoes of Multidrug-Resistant Plasmodium falciparum
Objectives: In the Gambia, chloroquine (CQ) plus sulphadoxine-pyrimethamine (SP) is the first-line antimalarial treatment. Plasmodium falciparum parasites carrying mutations associated with resistance to each of these drugs were present in 2001 but did not cause a significant loss of therapeutic…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.