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Artikel Jurnal Teks lengkap
Molecular Determinants of Ebola Virus Virulence in Mice
Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains elusive. While adult mice resist ZEBOV infection, the Mayinga strain of the virus has been adapted to…
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Macrophage Pro-Inflammatory Response to Francisella novicida Infection Is Regulated by SHIP
Francisella tularensis, a Gram-negative facultative intracellular pathogen infecting principally macrophages and monocytes, is the etiological agent of tularemia. Macrophage responses to F. tularensis infection include the production of pro-inflammatory cytokines such as interleukin (IL)-12, which…
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Artikel Jurnal Teks lengkap
PLoS Biology Issue Image | Vol. 4(7) July 2006
Tail ectoderm markers in the developing ascidian nervous system.: Shown are the expression patterns of markers of the Ciona intestinalis tail ectoderm in response to the activation of FGF and BMP signaling pathways. These pathways, together with Notch, control medio-lateral patterning and…
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Artikel Jurnal Teks lengkap
PLoS Medicine Issue Image | Vol. 3(7) July 2006
Chikungunya Outbreak in the Indian Ocean.: The cover refers to an ongoing outbreak of chikungunya fever in the Indian Ocean. The disease is caused by the chikungunya virus. Sylvain Brisse and colleagues report the first sequence analysis and comparison of viral gene sequences from the current…
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Artikel Jurnal Teks lengkap
High-Resolution Mutation Mapping Reveals Parallel Experimental Evolution in Yeast
Understanding the genetic basis of evolutionary adaptation is limited by our ability to efficiently identify the genomic locations of adaptive mutations. Here we describe a method that can quickly and precisely map the genetic basis of naturally and experimentally evolved complex traits using…
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Artikel Jurnal Teks lengkap
Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans
Caenorhabditis elegans TOM-1 is orthologous to vertebrate tomosyn, a cytosolic syntaxin-binding protein implicated in the modulation of both constitutive and regulated exocytosis. To investigate how TOM-1 regulates exocytosis of synaptic vesicles in vivo, we analyzed C. elegans tom-1 mutants. Our…
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Artikel Jurnal Teks lengkap
Evolution of Melanopsin Photoreceptors: Discovery and Characterization of a New Melanopsin in Nonmammalian Vertebrates
In mammals, the melanopsin gene (Opn4) encodes a sensory photopigment that underpins newly discovered inner retinal photoreceptors. Since its first discovery in Xenopus laevis and subsequent description in humans and mice, melanopsin genes have been described in all vertebrate classes. Until now…
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Silencing Viral Infection
The authors describe recent progress and obstacles to harnessing RNA interference to prevent or treat viral infection.
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Artikel Jurnal Teks lengkap
Should Society Allow Research Ethics Boards to Be Run As For-Profit Enterprises?
: An important mechanism for protecting human research participants is the prior approval of a clinical study by a research ethics board, known in the United States as an institutional review board (IRB). Traditionally, IRBs have been run by volunteer committees of scientists and clinicians working…
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Artikel Jurnal Teks lengkap
There Is No Such Thing as a Psychiatric Disorder/Disease/Chemical Imbalance
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Artikel Jurnal Teks lengkap
Questionable Advertising of Psychotropic Medications and Disease Mongering
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