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Artikel Jurnal Teks lengkap
Taiwan's Potential to Assist Developing Countries to Combat Infectious Diseases
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Artikel Jurnal Teks lengkap
PLoS Medicine and the Pharmaceutical Industry
The PLoS Medicine editors outline three journal policies that they believe help to break a "cycle of dependency that has formed between journals and the pharmaceutical industry.".
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Artikel Jurnal Teks lengkap
PLoS Computational Biology Issue Image | Vol. 2(7) July 2006
Rearrangement of protein structure : Subtle structural changes lead to distinct packing of the protein core. These changes appear due to accumulating mutations in the closely related homologous protein families. These random mutations in the ancestor protein (top) can lead to the rearrangement of…
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Artikel Jurnal Teks lengkap
PLoS Genetics Issue Image | Vol. 2(7) July 2006
Scanning EM micrograph of a Caenorhabditis elegans wild-type adult: Scanning EM micrograph of a Caenorhabditis elegans wild-type adult. Research reported by Brock et al. It describes a novel nuclear hormone receptor that regulates transcription of fatty acid desaturase genes in C. elegans. This…
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Artikel Jurnal Teks lengkap
PLoS Pathogens Issue Image | Vol. 2(7) July 2006
Candida biofilm: Biofilms are made up of a dense network of interacting cells. Shown here is a confocal scanning laser microscopy depth view of a Candida albicans biofilm, in which blue color represents cells closest to and red color represents cells farthest from the biofilm substrate. Most…
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Artikel Jurnal Teks lengkap
Module-Based Analysis of Robustness Tradeoffs in the Heat Shock Response System
Biological systems have evolved complex regulatory mechanisms, even in situations where much simpler designs seem to be sufficient for generating nominal functionality. Using module-based analysis coupled with rigorous mathematical comparisons, we propose that in analogy to control engineering…
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Artikel Jurnal Teks lengkap
Circadian Rhythmicity by Autocatalysis
The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA-…
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Artikel Jurnal Teks lengkap
Correction: How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory?
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Artikel Jurnal Teks lengkap
Molecular Simulations of Cotranslational Protein Folding: Fragment Stabilities, Folding Cooperativity, and Trapping in the Ribosome
Although molecular simulation methods have yielded valuable insights into mechanistic aspects of protein refolding in vitro, they have up to now not been used to model the folding of proteins as they are actually synthesized by the ribosome. To address this issue, we report here simulation studies…
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Artikel Jurnal Teks lengkap
From Functional Genomics to Functional Immunomics: New Challenges, Old Problems, Big Rewards
The development of DNA microarray technology a decade ago led to the establishment of functional genomics as one of the most active and successful scientific disciplines today. With the ongoing development of immunomic microarray technology—a spatially addressable, large-scale technology for…
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Artikel Jurnal Teks lengkap
Genome-Wide Analysis of Gene Expression during Early Arabidopsis Flower Development
Detailed information about stage-specific changes in gene expression is crucial for the understanding of the gene regulatory networks underlying development. Here, we describe the global gene expression dynamics during early flower development, a key process in the life cycle of a plant, during…
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Artikel Jurnal Teks lengkap
Haplotype Block Structure Is Conserved across Mammals
Genetic variation in genomes is organized in haplotype blocks, and species-specific block structure is defined by differential contribution of population history effects in combination with mutation and recombination events. Haplotype maps characterize the common patterns of linkage disequilibrium…
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Artikel Jurnal Teks lengkap
Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs
Fibroblasts are ubiquitous mesenchymal cells with many vital functions during development, tissue repair, and disease. Fibroblasts from different anatomic sites have distinct and characteristic gene expression patterns, but the principles that govern their molecular specialization are poorly…
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Artikel Jurnal Teks lengkap
Possible Ancestral Structure in Human Populations
Determining the evolutionary relationships between fossil hominid groups such as Neanderthals and modern humans has been a question of enduring interest in human evolutionary genetics. Here we present a new method for addressing whether archaic human groups contributed to the modern gene pool…
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Artikel Jurnal Teks lengkap
Who Ate Whom? Adaptive Helicobacter Genomic Changes That Accompanied a Host Jump from Early Humans to Large Felines
Helicobacter pylori infection of humans is so old that its population genetic structure reflects that of ancient human migrations. A closely related species, Helicobacter acinonychis, is specific for large felines, including cheetahs, lions, and tigers, whereas hosts more closely related to humans…
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Artikel Jurnal Teks lengkap
Matrix-Assisted Laser Desorption/Ionisation, Time-of-Flight Mass Spectrometry in Genomics Research
The beginning of this millennium has seen dramatic advances in genomic research. Milestones such as the complete sequencing of the human genome and of many other species were achieved and complemented by the systematic discovery of variation at the single nucleotide (SNP) and whole segment (copy…
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Artikel Jurnal Teks lengkap
The Influence of Injection Rate on the Hypnotic Effect of Propofol during Anesthesia: A Randomized Trial
Objective: Previous studies suggested that slow injection of propofol may increase the hypnotic effect during induction of anesthesia. The aim of the present study was therefore to investigate whether injection rate of propofol has an influence on its maximum effect. Design: Randomized…
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