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Artikel Jurnal Teks lengkap
A Randomised Trial Comparing Genotypic and Virtual Phenotypic Interpretation of HIV Drug Resistance: The CREST Study
Objectives: The aim of this study was to compare the efficacy of different HIV drug resistance test reports (genotype and virtual phenotype) in patients who were changing their antiretroviral therapy (ART). Design: Randomised, open-label trial with 48-week followup. Setting: The study was conducted…
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Artikel Jurnal Teks lengkap
New Prospects for Research on Manipulation of Insect Vectors by Pathogens
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Artikel Jurnal Teks lengkap
Correction: Listeria monocytogenes Traffics from Maternal Organs to the Placenta and Back
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Artikel Jurnal Teks lengkap
Roles of the Host Oxidative Immune Response and Bacterial Antioxidant Rubrerythrin during Porphyromonas gingivalis Infection
The efficient clearance of microbes by neutrophils requires the concerted action of reactive oxygen species and microbicidal components within leukocyte secretory granules. Rubrerythrin (Rbr) is a nonheme iron protein that protects many air-sensitive bacteria against oxidative stress. Using…
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Artikel Jurnal Teks lengkap
Gene Expression Analysis of Zebrafish Heart Regeneration
Mammalian hearts cannot regenerate. In contrast, zebrafish hearts regenerate even when up to 20% of the ventricle is amputated. The mechanism of zebrafish heart regeneration is not understood. To systematically characterize this process at the molecular level, we generated transcriptional profiles…
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Artikel Jurnal Teks lengkap
Similarity Selection and the Evolution of Sex: Revisiting the Red Queen
For over 25 years, many evolutionary ecologists have believed that sexual reproduction occurs because it allows hosts to change genotypes each generation and thereby evade their coevolving parasites. However, recent influential theoretical analyses suggest that, though parasites can select for sex…
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Artikel Jurnal Teks lengkap
Structural Organization of the 19S Proteasome Lid: Insights from MS of Intact Complexes
The 26S proteasome contains a 19S regulatory particle that selects and unfolds ubiquitinated substrates for degradation in the 20S catalytic particle. To date there are no high-resolution structures of the 19S assembly, nor of the lid or base subcomplexes that constitute the 19S. Mass spectra of…
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Artikel Jurnal Teks lengkap
Smashing Protein Complex Ions to Bits Reveals Their Structural Organization
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Artikel Jurnal Teks lengkap
Does Simple “Reassurance” Work in Patients with Medically Unexplained Physical Symptoms?
Escobar discusses a new study examining the impact of reassurance in three groups: patients with medically unexplained physical symptoms compared, healthy controls, and patients with depression.
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Artikel Jurnal Teks lengkap
Correction: Manslaughter by Fake Artesunate in Asia—Will Africa Be Next?
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Artikel Jurnal Teks lengkap
Regulating the Market in Human Research Participants
Lemmens and Miller critically examine "finder's fees" and other recruitment incentives issued to physicians for successfully referring patients to clinical trial investigators.
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Artikel Jurnal Teks lengkap
Abnormal Cortical Development after Premature Birth Shown by Altered Allometric Scaling of Brain Growth
Background: We postulated that during ontogenesis cortical surface area and cerebral volume are related by a scaling law whose exponent gives a quantitative measure of cortical development. We used this approach to investigate the hypothesis that premature termination of the intrauterine…
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Artikel Jurnal Teks lengkap
Why Reassurance Fails in Patients with Unexplained Symptoms—An Experimental Investigation of Remembered Probabilities
Background: Providing reassurance is one of physicians' most frequently used verbal interventions. However, medical reassurance can fail or even have negative effects. This is frequently the case in patients with medically unexplained symptoms. It is hypothesized that these patients are more likely…
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Artikel Jurnal Teks lengkap
Prospects for Advancing Tuberculosis Control Efforts through Novel Therapies
Background: Development of new, effective, and affordable tuberculosis (TB) therapies has been identified as a critical priority for global TB control. As new candidates emerge from the global TB drug pipeline, the potential impacts of novel, shorter regimens on TB incidence and mortality have not…
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Artikel Jurnal Teks lengkap
An Integrative Method for Accurate Comparative Genome Mapping
We present MAGIC, an integrative and accurate method for comparative genome mapping. Our method consists of two phases: preprocessing for identifying “maximal similar segments,” and mapping for clustering and classifying these segments. MAGIC's main novelty lies in its biologically intuitive…
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Artikel Jurnal Teks lengkap
Intrinsic Disorder Is a Common Feature of Hub Proteins from Four Eukaryotic Interactomes
Recent proteome-wide screening approaches have provided a wealth of information about interacting proteins in various organisms. To test for a potential association between protein connectivity and the amount of predicted structural disorder, the disorder propensities of proteins with various…
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Artikel Jurnal Teks lengkap
Transient Resetting: A Novel Mechanism for Synchrony and Its Biological Examples
The study of synchronization in biological systems is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. In this paper, by using simple dynamical systems theory, we present a novel mechanism, named transient resetting, for the…
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